Search results for "PAM"
showing 10 items of 1768 documents
La Educación para el Desarrollo Sostenible aplicada a la enseñanza-aprendizaje del alemán como lengua extranjera
2022
Desde la irrupción de la Agenda 2030 para el Desarrollo Sostenible, que constituye para todas las personas una oportunidad y una exigencia para responder a los desafíos del mundo, las universidades europeas dentro del espacio generado por la European Higher Education Area (EHEA) asumen su responsabilidad. El carácter integral de la Agenda 2030 permite a la Universidad la construcción de un mundo comprometido con el desarrollo sostenible e inclusivo, la justicia, la dignidad y la igualdad de las personas, dando respuesta a los desafíos que el contexto global presenta para las universidades y para la sociedad internacional en su conjunto. La Educación para el Desarrollo Sostenible (EDS), por …
A NEW DOPAMINE-AMINOACID CONJUGATE: SYNTHESIS AND DETERMINATION OF PHYSICO-CHEMICAL PROPERTIES USEFUL TO CROSS THE BBB
2012
Solapamiento del nicho trófico en un área de cría en la costa portuguesa
2002
The diets and the trophic niche overlap between seven flatfish species were studied in a coastal nursery adjoining to the Tagus estuary (Portugal). Fish were sampled monthly, from March to November 1999, using a beach seine. Arnoglossus imperialis (Rafinesque, 1810), Arnoglossus laterna (Walbaum, 1792) and Arnoglossus thori Kyle, 1913, fed mainly on crustaceans. The diets of Buglossidium luteum (Risso, 1810) and Dicologoglossa cuneata (Moreau, 1881) were mainly composed of Bivalvia and Polychaeta, while for Scophthalmus rhombus (Linnaeus, 1758) the main food items were Mysidacea and Teleostei. The diet of Pegusa lascaris (Risso, 1810) was mainly composed by Cumacea, Bivalvia, Decapoda and A…
112 Workshop Summary: DOPAMINERGIC MECHANISMS OF PAIN CONTROL
2007
Development and validation of a liquid chromatography tandem mass spectrometry method for the analysis of beta-agonists in animal feed and drinking w…
2010
A reproducible, sensitive and selective multiresidue analytical method for seven beta-agonists: clenbuterol (CBT), clenpenterol (CPT), ractopamine (RTP), brombuterol (BBT), mabuterol (MBT), mapenterol (MPT), and hydroxymethylclenbuterol (HMCBT) was developed and validated by using liquid chromatography tandem mass spectrometry (LC-MS/MS) in feed and drinking water samples. The validation was achieved according to the criteria laid down in the Commission Decision 2002/657/EC, however it was necessary to use minimum required performance limits (MRPLs) proposed by the Community Reference Laboratories (CRLs) due to the lack of maximum residue limits (MRLs) for beta-agonists. By setting up these…
Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness
2017
International audience; Eating-disorders (EDs) consequences to human health are devastating, involving social, mental, emotional, physical and life-threatening aspects, concluding on impairment and death in cases of extreme anorexia nervosa. It also implies that people suffering an ED need to find psychiatric and psychological help as soon as possible to achieve a fully physical and emotional recovery. Unfortunately, to date, there is a crucial lack of efficient clinical treatment to these disorders. In this review, we present an overview concerning the actual pharmacological and psychological treatments, the knowledge of cells, circuits, neuropeptides, neuromodulators and hormones in the h…
Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity.
2009
Strong evidence indicates that oxidative stress may be causally involved in the pathogenesis of Parkinson's disease. We have employed human dopaminergic neuroblastoma cells and rat primary mesencephalic neurons to assess the protective potential of three novel bisarylimine antioxidants on dopaminergic cell death induced by complex I inhibition or glutathione depletion. We have found that exceptionally low concentrations (EC(50) values approximately 20 nM) of these compounds (iminostilbene, phenothiazine, and phenoxazine) exhibited strong protective effects against the toxicities of MPP(+), rotenone, and l-buthionine sulfoximine. Investigating intracellular glutathione levels, it was found t…
Ursolic acid ameliorates stress and reactive oxygen species in C. elegans knockout mutants by the dopamine Dop1 and Dop3 receptors.
2020
Abstract Background Depression and stress-related disorders are leading causes of death worldwide. Standard treatments elevating serotonin or noradrenaline levels are not sufficiently effective and cause adverse side effects. A connection between dopamine pathways and stress-related disorders has been suggested. Compounds derived from herbal medicine could be a promising alternative. We examined the neuroprotective effects of ursolic acid (UA) by focusing on dopamine signalling. Methods Trolox equivalent capacity assay was used to determine the antioxidant activities of UA in vitro. C. elegans N2 wildtype and dopamine receptor-knockout mutants (dop-1-deficient RB665 and dop-3-deficient LX70…
Antispasmodic effect of 4'-methylepigallocatechin on guinea pig ileum.
2012
AbstractThe antispasmodic effect of 4′-methylepigallocatechin (MEC), which was isolated from Maytenus rigida Mart (Celestraceae), was investigated in vitro in guinea pig intestinal segments. In the isolated ileum, MEC (1 nM–100μM) did not modify the ileal spontaneous tonus or the electrically elicited contractions. MEC (8μM) significantly (p<0.01) reduced the submaximal contractions induced by histamine (2μM), carbachol (100μM) and BaCl2 (0.03M). An additive relaxing action (p<0.001) was observed by co-incubation of verapamil (10 nM) and MEC (8μM). Although MEC (1nM–100μM) did not modify the contractions elicited by 60mM KCl, it significantly reduced the CaCl2 contractile response without c…
Tetovējumu nozīme jauniešu vidū Latvijā
2015
Bakalaur darbs ‘’Atklāti redzami tetovējumi: simbolika un pamatojums’’ ir pētījums par to, kā vidusmēra sabiedrības pārstāvji kuru rokas vai kaklu noklāj atklāti redzami tetovējumi tos pamato ar tikai sev zināmiem faktoriem. Izmantojot Artūra Franka teoriju par ievainojumu kā komunikācijas līdzekli, tetovējumi tiek skatīti kā neverbāli komunikācijas līdzekļi un to simbolika tiek skatīta, kā vētījums kas tiek nodots ar komunikācijas palīdzību. Pamatojums tiek aplūkots Margaritas DeMello izvirzītā pieņēmuma skatījuma par to, ka tetovējums ir pašizpausmes līdzeklis kas tiek izmantots patstāvības iegūšanai. Pētījuma mērķis – uzzināt un izprast kā cilvēki pamato to, kāpēc viņi ir izvēlējušies ta…