Search results for "PAM"
showing 10 items of 1768 documents
Medication for Acromegaly Reduces Expression of MUC16, MACC1 and GRHL2 in Pituitary Neuroendocrine Tumour Tissue
2021
Acromegaly is a disease mainly caused by pituitary neuroendocrine tumor (PitNET) overproducing growth hormone. First-line medication for this condition is the use of somatostatin analogs (SSAs), that decrease tumor mass and induce antiproliferative effects on PitNET cells. Dopamine agonists (DAs) can also be used if SSA treatment is not effective. This study aimed to determine differences in transcriptome signatures induced by SSA/DA therapy in PitNET tissue. We selected tumor tissue from twelve patients with somatotropinomas, with half of the patients receiving SSA/DA treatment before surgery and the other half treatment naive. Transcriptome sequencing was then carried out to identify diff…
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.
2006
Contains fulltext : 35205.pdf (Publisher’s version ) (Closed access) Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide polymorphisms (SNPs) spanning 51 candidate genes involved in the regulation of neurotransmitter pathways, particularly dopamine, nor…
The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)).
2012
Endocannabinoids exert numerous effects in the CNS under physiological and pathological conditions. The aim of the present study was to examine whether the endocannabinoid N-arachidonoyldopamine (NADA) may protect neurons in excitotoxically lesioned organotypic hippocampal slice cultures (OHSC). OHSC were excitotoxically lesioned by application of N-methyl-d-aspartate (NMDA, 50 μM) for 4 h and subsequently treated with different NADA concentrations (0.1 pM-50 μM) alone or in combination with cannabinoid receptor antagonists. NADA protected dentate gyrus granule cells and caused a slight reduction in the number of microglial cells. The number of degenerated neurons significantly decreased be…
Circuit Specific Functions of Cannabinoid CB1 Receptor in the Balance of Investigatory Drive and Exploration
2011
Well balanced novelty seeking and exploration are fundamental behaviours for survival and are found to be dysfunctional in several psychiatric disorders. Recent studies suggest that the endocannabinoid (eCB) system is an important control system for investigatory drive. Pharmacological treatment of rodents with cannabinergic drugs results in altered social and object investigation. Interestingly, contradictory results have been obtained, depending on the treatment, drug concentration and experimental conditions. The cannabinoid type 1 (CB1) receptor, a central component of the eCB system, is predominantly found at the synapses of two opposing neuronal populations, i.e. on inhibitory GABAerg…
Acetaldehyde as a drug of abuse: insight into AM281 administration on operant-conflict paradigm in rats
2013
Increasing evidence focuses on acetaldehyde (ACD) as the mediator of the rewarding and motivational properties of ethanol. Indeed, ACD stimulates dopamine release in the nucleus accumbens and it is self-administered under different conditions. Besides the dopaminergic transmission, the endocannabinoid system has been reported to play an important role in ethanol central effects, modulating primary alcohol rewarding effect, drug-seeking and relapse behaviour. Drug motivational properties are highlighted in operant paradigms which include response-contingent punishment, a behavioural equivalent of compulsive drug use despite adverse consequences. The aim of this study was thus to characterize…
Cambio Climático. Objetivo Durbán
2011
Revista Eureka sobre Enseñanza y Divulgación de las Ciencias está contribuyendo, con la publicación de numerosos trabajos y, en particular, con su sección "Educación científica y sostenibilidad", a los objetivos de la Década de la educación por un futuro sostenible, instituida por Naciones Unidas para que los educadores de todos los niveles y áreas contribuyamos a proporcionar una percepción correcta de los problemas a los que se enfrente la humanidad y a fomentar actitudes y comportamientos favorables para el logro de un futuro sustentable. Acogiéndonos a este compromiso de Revista Eureka queremos hacernos eco de los resultados de la Cumbre del Clima celebrada en Cancún en diciembre de 201…
El cambio climático, ¿una cuestión de fanatismo ecológico?
2008
Climatic change has given place to pseudo-scientific debates that demand clarification in order to make possible citizens responsible attitudes and behavior oriented towards the attainment of a culturally plural and physically sustainable development.
De Cancún a Durbán: la necesidad de un activismo basado en el conocimiento
2010
El Caderno Brasileiro de Ensino de Física ha hecho suyo los llamamientos de Naciones Unidas - que han culminado con la institución de la Década de la educación por un futuro sostenible - para que los educadores de todos los niveles y áreas prestemos una atención sistemática a la situación del mundo y contribuyamos a proporcionar una percepción correcta de los problemas a los que se enfrente la humanidad y a fomentar actitudes y comportamientos favorables para el logro de un futuro sustentable. Llamamientos convergentes se han realizado a los miembros de la comunidad científica. Podemos recordar, a título de ejemplo, el artículo editorial publicado en 1998 por Jane Lubchenco, presidenta a la…
Caisses de sécurité sociale : ne notifiez plus vos décisions !
2019
International audience
Integrated non-invasive approach to atherosclerosis with cardiac CT and carotid ultrasound in patients with suspected coronary artery disease
2017
The aim of the study was to compare the atherosclerotic disease in the coronary and carotid arteries in patients who underwent non-invasive imaging for suspected stable coronary artery disease (CAD). 107 patients (64 men, age 59 ± 12) with atypical chest pain underwent cardiac CT (CCT) and carotid ultrasound (US) on the same day. Severity (obstructive or not-obstructive disease), location, shape, and composition of atherosclerotic plaques in the two districts were evaluated. Patients presented normal coronary arteries in 36 % (n = 38), not-obstructive CAD in 36 % (n = 39), and obstructive CAD in 28 % (n = 30), while had normal carotid arteries in 53 % (n = 57), not-obstructive disease in 44…