Search results for "PARKIN"
showing 10 items of 468 documents
Planning and executing sequential motor acts in Parkinson Disease
1997
Many experimental evidences highlighted that Parkinson Disease (PD) patients are particularly impaired in performing a sequence of movements. In the present experiment we focused to study how PD patients plan and execute an action constituted by the sequence of reaching-grasping an object (first motor act) and placing it on a second target (second motor act). We wished to determine whether properties of the target of the second motor act influenced the kinematics of first motor act. The results showed that PD patients modified, as the controls, the initial ballistic phase of reaching according to variation of second target position (object extrinsic properties). In particular, peak accelera…
Validació de composts potencialment terapèutics per a la malaltia de Parkinson en un model cel·lular humà
2019
La malaltia de Parkinson (PD) és un trastorn motriu de tipus neurodegeneratiu caracteritzat per la mort de les neurones dopaminèrgiques de la substància nigra pars compacta com a conseqüència de l’augment de l’estrès oxidatiu, la disfunció mitocondrial i la fallada energètica. En els darrers anys s’han identificat diverses formes de parkinsonisme familiar causades per mutacions en gens concrets, com DJ-1. Pel que fa als tractaments actuals, aquests no aturen la neurodegeneració, de manera que és necessari un canvi de paradigma cap a la identificació de nous composts amb efecte neuroprotector. Estudis recents han demostrat com l’augment de la taxa glicolítica podria constituir un mecanisme e…
The Clock'N Test as a Possible Measure of Emotions: Normative Data Collected on a Non-clinical Population.
2016
International audience; Objective: At present emotional experience and implicit emotion regulation (IER) abilities are mainly assessed though self -reports, which are subjected to several biases. The aim of the present studies was to validate the Clock'N test, a recently developed time estimation task employing emotional priming to assess implicitly emotional reactivity and IER. Methods: In Study 1, the Clock' N test was administered to 150 healthy participants with different age, laterality and gender, in order to ascertain whether these factors affected the test results. In phase 1 participant were asked to judge the duration of seven sounds. In phase 2, before judging the duration of the…
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology
2020
Amyloids are fibrillar protein aggregates associated with diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type II diabetes and Creutzfeldt–Jakob disease. The process of amyloid polymerization involves three pathological protein transformations; from natively folded conformation to the cross-β conformation, from biophysically soluble to insoluble, and from biologically functional to non-functional. While amyloids share a similar cross-β conformation, the biophysical transformation can either take place spontaneously via a homogeneous nucleation mechanism (HON) or catalytically on an exogenous surface via a heterogeneous nucleation mechanism (HEN). Here, we postulate that…
Exergaming in the treatment of gait, balance, and quality of life in Parkinson's disease: Overview of systematic reviews
2023
Introduction: Postural instability and gait impairments are common in people with PD, both of which have a negative effect on their quality of life. Systematic reviews have demonstrated benefits of using exergaming in enhancing these outcomes. However, there is no consensus over whether exergaming therapy is better than conventional physical therapy for enhancing gait, balance, and quality of life. Objectives: The aim of this overview is to systematically synthesize and evaluate the available evidence found in published systematic reviews and meta-analyses, on the effects of exergaming therapy on balance, gait, and quality of life, compared to conventional physical therapy or no interventio…
La ricerca clinica tra scienza ed etica nella malattia di Parkinson.
2008
Fragment‐ and Negative Image‐Based Screening of Phosphodiesterase 10A Inhibitors
2019
A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein‐bound ligand(s) are seamlessly combined with the negative image of the target's ligand‐binding cavity. This cavity‐ and fragment‐based hybrid model, namely its shape and electr…
Design of a Smart Car Park with PV generation and BESS for Grid-on and Grid-off Operation. The SMARTEP Project
2022
The paper presents the design state of a smart car park shelter for electric vehicle in the campus of the University of Palermo. The car park is supplied by the main grid and by a 40 kW photovoltaic system and is equipped with a Li-ion battery storage system with capacity 42 kWh. The hybrid plant is designed in order to operate both in connection with the main grid and in stand-alone mode, supplying, in this case, all car park's loads and providing one recharge to an electric vehicle. Moreover, the energy storage system and, eventually, the battery of one or more cars with V2G technologies, can be managed for providing ancillary services to the grid. In the paper, the design of the system a…
CLINICAL EFFECTS OF DIFFERENT MONTAGES OF TRANSCRANIAL DIRECT CURRENT STIMULATION IN PATIENTS WITH PARKINSON’DISEASE
2014
Efectos de la rehabilitación de marcha con tareas duales en pacientes con enfermedad de Parkinson: ensayo controlado aleatorizado
2018
La rehabilitación física funcional permite a los pacientes desenvolverse en ambientes cotidianos, disminuyendo el riesgo de caer y las lesiones concomitantes en todos los escenarios posibles. Para lograr este objetivo, la rehabilitación de la marcha que incluye tareas duales es adecuada en patologías como la enfermedad de Parkinson (EP), ya que las alteraciones de la marcha parkinsoniana tienen un gran impacto en la funcionalidad y la percepción de la calidad de vida de los pacientes. Una tarea dual consiste, por ejemplo, en caminar mientras se ejecuta una tarea adicional cognitiva o motora con los brazos. El objetivo principal de este trabajo es diseñar un programa de rehabilitación de mar…