Search results for "PASS"

IL PASSAPORTO BIOLOGICO E IL DISALLINEAMENTO TRA IL DOPING E L’ANTIDOPING

2014

First Measurement of Transverse-Spin-Dependent Azimuthal Asymmetries in the Drell-Yan Process

2017

The first measurement of transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan (DY) process is reported. We use the CERN SPS 190 GeV/$c$, $\pi^{-}$ beam and a transversely polarized ammonia target. Three azimuthal asymmetries giving access to different transverse-momentum-dependent (TMD) parton distribution functions (PDFs) are extracted using dimuon events with invariant mass between 4.3 GeV/$c^2$ and 8.5 GeV/$c^2$. The observed sign of the Sivers asymmetry is found to be consistent with the fundamental prediction of Quantum Chromodynamics (QCD) that the Sivers TMD PDFs extracted from DY have a sign opposite to the one extracted from semi-inclusive deep-inelastic sc…

Sivers asymmetry extracted in SIDIS at the hard scales of the Drell-Yan process at COMPASS

2017

Proton transverse-spin azimuthal asymmetries are extracted from the COMPASS 2010 semi-inclusive hadron measurements in deep inelastic muon-nucleon scattering in those four regions of the photon virtuality $Q^2$, which correspond to the four regions of the di-muon mass $\sqrt{Q^2}$ used in the ongoing analysis of the COMPASS Drell-Yan measurements. This allows for a future direct comparison of the nucleon transverse-momentum-dependent parton distribution functions extracted from these two alternative measurements. Various two-dimensional kinematic dependences are presented for the azimuthal asymmetries induced by the Sivers transverse-momentum-dependent parton distribution function. The inte…

Computer simulations of bioequivalence trials: selection of design and analyte in BCS drugs with first-pass hepatic metabolism: linear kinetics (I).

2008

Modeling and simulation approaches are useful tools to assess the potential outcome of different scenarios in bioequivalence studies. The aim of this study is to propose a new and improved semi-physiological model for bioequivalence trial simulations and apply it for all BCS (Biopharmaceutic Classification System) drug classes with non-saturated first-pass hepatic metabolism. The semi-physiological model was developed in NONMEM VI to simulate bioequivalence trials. Parent drug and metabolite levels for both reference and test were simulated. Eight types of drugs (with high or low permeability and high or low solubility (class I to IV) and high or low intrinsic clearance) were considered in …

Biopartitioning micellar separation methods: modelling drug absorption

2003

The search for new pharmacologically active compounds in drug discovery programmes often neglects biopharmaceutical properties as drug absorption. As a result, poor biopharmaceutical characteristics constitute a major reason for the low success rate for candidates in clinical development. Since the cost of drug development is many times larger than the cost of drug discovery, predictive methodologies aiding the selection of bioavailable drug candidates are of profound significance. This paper has been focussed on recent developments and applications of chromatographic systems, particularly those systems based on amphiphilic structures, in the frame of alternative approaches for estimating t…

Zugangswege f�r die Medikamentenapplikation bei Herzkreislaufstillstand

1996

Selecting a route for drug administration during CPR requires consideration of the speed with which access can be obtained, the technical difficulties involved in performing the procedure, the associated risk of complications, delays in drug delivery to the central circulation, and the duration of effective drug levels following injection. The peripheral venous route is the safest method, and drug delivery can be enhanced by a fluid bolus after injection of the medication. The circulation time is shortest after central venous injection, but there is some risk of complications. The femoral route is associated with a high incidence of unsuccessful catherization. The endotracheal tube provides…

Dual-Source Computed Tomography (DSCT) Angiography for the Visualization of Coronary Artery Bypass Grafts (CABG)

2007

Modèle dynamique multiniveau et holonique pour la simulation d'un système complexe à grande échelle avec environnement spatial : Application à la sim…

2020

Nowadays, with the emergence of connected objects and cars, road traffic systems become more and more complex and exhibit hierarchical behaviours at several levels of detail. The multilevel modeling approach is an appropriate approach to represent traffic from several perspectives. Multilevel models are also an appropriate approach to model large-scale complex systems such as road traffic. However, most of the multilevel models of traffic proposed in the literature are static because they use a set of predefined levels of detail and these representations cannot change during simulation. Moreover, these multilevel models generally consider only two levels of detail. Few works have been inter…

Cautionnement. Cautions solidaires et débiteur principal en liquidation judiciaire. Portée du rejet d'une créance au passif d'un des cofidéjusseurs à…

2015

International audience; (Com., 18 novembre 2014, n° 13-23.976, P+B, Caisse de Crédit Mutuel Mulhouse Concorde c/ M. et Mme X., D. 2014. 2405 ; RTD com. 2015. 152, obs. A. Martin-Serf ; Gaz. Pal. 18 au 20 janv.2015, p. 33, note E. Le Corre-Broly)

2021

Abstract. Foreland fold-and-thrust belts (FTBs) record long-lived tectono-sedimentary activity, from passive margin sedimentation, flexuring, and further evolution into wedge accretion ahead of an advancing orogen. Therefore, dating fault activity is fundamental for plate movement reconstruction, resource exploration, and earthquake hazard assessment. Here, we report U–Pb ages of syn-tectonic calcite mineralizations from four thrusts and three tear faults sampled at the regional scale across the Jura fold-and-thrust belt in the northwestern Alpine foreland (eastern France). Three regional tectonic phases are recognized in the middle Eocene–Pliocene interval: (1) pre-orogenic faulting at 48.…