Search results for "PC"

Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells

1999

Clusterin (apolipoprotein J) is an extracellular glycoprotein that might exert functions in development, cell death and lipid transport. Clusterin gene expression is elevated at sites of tissue remodelling, such as differentiation and apoptosis; however, the signals responsible for this regulation have not been identified. We use here the clusterin gene as a model system to examine expression in PC12 cells under the control of differentiation and proliferation signals produced by nerve growth factor (NGF) and by epidermal growth factor (EGF) respectively. NGF induced clusterin mRNA, which preceded neurite outgrowth typical of neuronal differentiation. EGF also activated the clusterin mRNA, …

Interactions between cholinergic and fibroblast growth factor receptors in brain trophism and plasticity

2014

Acetylcholine, acting on both nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs), plays a role in the regulation of synaptic plasticity, being involved in the regulation of cellular processes and cognitive functions, such as learning, memory and attention. Recently, G protein coupled receptors (GPCRs), including mAChRs, have been reported to transactivate tyrosine-kinase receptors (RTK), such as epidermal growth factor receptor (EGFR), and initiate their intracellular signaling. In this minireview we have first analysed the RTK transactivation mechanisms, involving cholinergic receptors, and thereafter the interplay between AChR and neurotrophic factor systems built up by FGF2 a…

Plasmid conjugation from Proteobacteria as evidence for the origin of xenologous genes in Cyanobacteria

2014

Comparative genomics have shown that 5% of Synechococcus elongatus PCC 7942 genes are of probable proteobacterial origin. To investigate the role of interphylum conjugation in cyanobacterial gene acquisition, we tested the ability of a set of prototype proteobacterial conjugative plasmids (RP4, pKM101, R388, R64, and F) to transfer DNA from Escherichia coli to S. elongatus. A series of BioBrick-compatible, mobilizable shuttle vectors was developed. These vectors were based on the putative origin of replication of the Synechococcus resident plasmid pANL. Not only broad-host-range plasmids, such as RP4 and R388, but also narrower-host-range plasmids, such as pKM101, all encoding MPFT-type IV …

Estudio funcional de polimorfismos de la vía de activación de la proteína C

2017

La trombosis venosa es una enfermedad multifactorial, originada por una suma de factores endógenos que predisponen al evento trombótico bajo la influencia de una exposición a factores exógenos. Dicha predisposición engloba factores de riesgo adquiridos que provocan en el individuo una disminución de su capacidad para enfrentarse a las alteraciones normales de la hemostasia, producto de la edad, dislipemias, diabetes, embarazo o puerperio, inmovilizaciones, intervenciones quirúrgicas, uso de píldoras anticonceptivas, tratamientos hormonales, etc. Además, se han identificado diferentes factores de riesgo genéticos, tales como las mutaciones factor V Leiden y protrombina G20210A, y el déficit …

Guillem Peire de Cazals. D’una leu chanso ai cor que m’entremeta (BdT 227.8)

2016

L’articolo propone una nuova edizione critica di D’una leu chanso ai cor que m’entremeta di Guillem Peire de Cazals, accompagnata da un commento volto a contestualizzare la canzone entro la modalità poetica della mala canso. Il testo, una vera e propria ‘canzone di disamore’, è databile agli anni 1229-1230 e costituisce un cambiamento di rotta da parte del trovatore caorsino, sia sul piano tematico che sul piano stilistico. Il riflesso di tale cambiamento è ravvisabile fin dal binomio incipitale, leu chanso – che si carica di un particolare sovrasenso retorico –, e prosegue nel corso del récit, dove si rintraccia l’uso di un vocabolario e di temi tipici della ‘modalità’ del disamore. This a…

Yeast biota of naturally fermented black olives in different brines made from cv. Gemlik grown in various districts of the Cukurova region of Turkey.

2015

In this study, the yeast microbiota of naturally fermented black olives made from cv. Gemlik, grown in three different districts of the Cukurova region of Turkey, were investigated. Fermentations were conducted for 180days in three different brines, including NaCl 10% w/v, NaCl 8% w/v and NaCl 8% w/v added with glucose 0.5%. In total, 223 yeasts were isolated and then identified by PCR-RFLP analysis of the 5.8S ITS rRNA region and sequence information for the D1/D2 domains of the 26S rRNA gene. A broad range of yeast biodiversity was identified, including eight genera and nine species. Candida boidinii (41%), Wickerhamomyces anomalus (32%) and Saccharomyces sp. (18%) were predominant yeasts…

Examination of Escherichia coli from poultry for selected adhesin genes important in disease caused by mammalian pathogenic E. coli

2001

A collection of 1601 extraintestinal and intestinal Escherichia coli isolated from chickens, turkeys and ducks, in Belgium, France and Spain, was hybridised with gene probes specific for fimbrial and afimbrial adhesins (F17, F18, SSfa/F1C, Bfp, Afa, Cs31A, IntiminEae, Aida-1) of intestinal, urinary and invasive E. coli of mammals and with a probe specific for the P (Pap/Prs) fimbrial adhesin of urinary and invasive E. coli of mammals and birds. Three hundred and eighty-three strains (23.9%) were P-positive, 76 strains (4.8%) were Afa-positive, 75 strains (4.7%) were F17-positive, 67 strains (4.2%) were S-positive, 23 (1.4%) were Intimin-positive, and all were F18-, Cs31A-, Aida1- and Bfp-ne…

Turquía y Giscard

2002

Recepcja twórczości Ricardy Huch w Niemczech - wokół jubileuszu 150. rocznicy urodzin poetki w 2014 roku

2017

Niniejszy artykuł przedstawia stan badań nad recepcją twórczości niemieckiej pisarki Ricardy Huch w Niemczech wokół jubileuszu 150. rocznicy jej urodzin w 2014 roku. Renesans recepcji życia i twórczości Huch w roku jubileuszowym można rozpatrywać w następujących kategoriach: konferencje i sympozja, odczyty, wystawy i wizualizacje, oficjalne uroczystości w Turyngii, utworzenie strony internetowej poświęconej życiu, twórczości i recepcji dzieła autorki oraz publikacje będące zwieńczeniem naukowym roku jubileuszowego. Inicjatywy podjęte przez naukowców, społeczników i lokalne instytucje samorządowe skierowane do różnych grup społecznych w Niemczech pokazały, że twórczość pisarska Ricardy Huch …

Difusión de innovaciones y redes sociales en la agricultura. Análisis de tendencias en la Comunidad Valenciana y Reino Unido

2023

Esta tesis doctoral se estructura en torno a tres temas principales de estudio. El primer tema (Artículo 1) se centra en el análisis bibliométrico de la difusión de innovaciones en la agricultura. El objetivo es obtener una comprensión integral de las tendencias de investigación en esta área, proporcionando una base sólida para aplicaciones prácticas. El segundo tema (Artículos 2, 4 y 5) gira en torno al análisis de los procesos de adopción y difusión de innovaciones en la agricultura sostenible. Esto incluye dos estudios realizados en la Comunidad Valenciana (Artículos 2 y 5) y otro estudio realizado en el Reino Unido (Artículo 4). Los objetivos de este tema son dobles. En primer lugar, an…