Search results for "PC"

Comparing FPCA Based on Conditional Quantile Functions and FPCA Based on Conditional Mean Function

2019

In this work functional principal component analysis (FPCA) based on quantile functions is proposed as an alternative to the classical approach, based on the functional mean. Quantile regression characterizes the conditional distribution of a response variable and, in particular, some features like the tails behavior; smoothing splines have also been usefully applied to quantile regression to allow for a more flexible modelling. This framework finds application in contexts involving multiple high frequency time series, for which the functional data analysis (FDA) approach is a natural choice. Quantile regression is then extended to the estimation of functional quantiles and our proposal exp…

DISEASES DIVERSITY FOR FLAX GENETIC RESOURCES IN LATVIA

2017

Flax ( Linum usitatissimum L) yield of stem and seeds and them quality is influenced by a number of harmful diseases but investigation about pathogens in recent years have not been done in Latvia.  Each stage of development of disease is important in the pathogen life cycle and requires certain condition. Goal of this study have identify possibilities of the pathogens and were assess disease severity depending on the genotypes on flax in variable environmental conditions. The resistance to the diseases for 24 flax genotypes and standard variety ‘Vega 2’ were evaluated. The field trials have been carried out over the period from 2015 to 2016 at the Research Centre of Priekuli, part of Vilani…

Contamination of Wheat, Barley, and Maize Seeds with Toxigenic Fusarium Species and Their Mycotoxins in Tunisia

2021

Abstract Background Fusarium is a worldwide distributed fungal genus. It includes different species pathogenic to cereals among others crops. Some of these species can also produce toxic compounds toward animals and humans. Objective In this work, occurrence of fumonisins B1+B2, zearalenone, type A trichothecenes (T-2 and HT-2 toxins), and type B trichothecenes (deoxynivalenol[DON] and nivalenol[NIV]) was studied in 65 samples of stored and freshly harvested wheat, barley, and maize collected in Tunisia. Methods Mycotoxins analyses were performed by using gas chromatography for type B trichothecenes and HPLC for other mycotoxins. Obtained results were compared with the presence of mycotoxig…

Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?

2020

G-protein-coupled receptors constitute the most diverse and largest receptor family in the human genome, with approximately 800 different members identified. Given the well-known metabolic alterations in cancer development, we will focus specifically in the 19 G-protein-coupled receptors (GPCRs), which can be selectively activated by metabolites. These metabolite sensing GPCRs control crucial processes, such as cell proliferation, differentiation, migration, and survival after their activation. In the present review, we will describe the main functions of these metabolite sensing GPCRs and shed light on the benefits of their potential use as possible pharmacological targets for cancer treat…

Dense matter with eXTP

2019

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry (eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics o…

STRATEGIE PER IL MIGLIORAMENTO DELLA PRODUZIONE E LO SVILUPPO DI MOLECOLE AD ATTIVITÀ ANTIBIOTICA DI ORIGINE NATURALE O DI SINTESI CHIMICA

The emergence of multi-drug resistant (MDR) bacterial strains is an urgent problem derived from the widespread and uncontrolled use of antibiotics. Therefore, new arrays of lead compounds exerting antimicrobial activity are necessary to contrast the spreading of MDR pathogens. Between 1980 and 2003, the interest in scientific research programs aimed to the new drug discovery by large pharmaceutical companies progressively decreased due to increasing costs in the respect of i) the low discovery rate of new leads, ii) the small amounts of product recovery needing process optimization and, finally, iii) regulatory obstacles associated with long-lasting pre-clinical and clinical trials for ther…

GEM-TPC-ilmaisimen testimittausten datan analyysi

2017

GEM-TPC-ilmaisin on kaasutäytteinen hiukkasilmaisin, jolla pystytään mittaaamaan hyvin pieniä sähköisiä signaaleja ja niiden syntypaikkaa ilmaisimessa. Näitä ilmaisimia tullaan tulevaisuudessa käyttämään mm. FAIRtutkimuslaitoksen Super-FRS-nimisessä fragmenttiseparaattorissa. Tässä tutkielmassa analysoin kesällä 2016 GEM-TPC:llä GSI:ssä suoritettuja ilmaisintestimittauksia ROOT-ohjelmiston avulla. Alkuun kerron, miksi GEM-TPC-ilmaisin on lähdetty suunnittelemaan, minkälaisia mittauksia ja missä sillä on tarkoitus tehdä. Tutkielman loppupuolella analysoin testimittausten tuloksia. GSI:ssä GEM-TPC:tä testattiin Xe- ja C-suihkujen avulla. Tässä tutkielmassa perehdyn syvemmin C-suihkusta tehtyi…

First report of grapevine fleck virus in vineyards of Bosnia and Herzegovina

2020

Grapevine is one of the most important fruit crops in Bosnia and Herzegovina with an annual production of around 40 thousand tons in 2018 (FAOSTAT, http://www.fao.org/ faostat/en/#data/QC). Production of grapevine in the country is mainly concentrated in vineyards in the Lištica and Mostar regions of Herzegovina with the two predominant autochthonous cultivars ‘Žilavka’ and ‘Blatina’. Grapevine fleck virus (GFkV) from the genus Maculavirus in the family Tymoviridae is a phloem limited virus with a positive-sense single-stranded RNA genome (Dreher et al. 2012). GFkV is associated with fleck disease of Vitis spp. In order to investigate the current status of GFkV in Bosnia and Herzegovina, 80…

GIV noroviruses and other enteric viruses in bivalves: a preliminary study.

2012

We evaluated the presence of the enteric viruses: norovirus, adenovirus, enterovirus, astrovirus, hepatitis A virus, and hepatitis E virus in bivalves using nested PCR methods and cell culture assays. Noroviruses GII.4 and GIV.1, adenoviruses types 1 and 2, hepatitis A, and echovirus type 7 were detected in the shellfish tested, which were often co-infected. This is the first study to detect such a high level of viral contamination in Italian mussels (up to four different viral groups in a single sample), and the first to document the presence of GIV NoV in shellfish.

Distribución, función y vías de señalización de los adrenoceptores β a nivel vascular

2014

Se ha analizado la contribución de los diferentes subtipos de adrenoceptores (AR) β (β1, β2 β3) en la vasodilatación, determinando su localización en las diferentes células vasculares y evaluando la implicación de las vías de señalización adenilato ciclasa (AC)/AMPc/PKA y/o NO/guanilato ciclasa soluble (GCs)/GMPc, en dos lechos vasculares representantes de: los vasos de resistencia, como la arteria mesentérica de resistencia (A.M.R.) de rata, y de conductancia, como la aorta de rata. Los resultados obtenidos muestran que, a pesar de que los tres subtipos de AR β se expresan en ambos vasos, su participación en la respuesta funcional, así como la vía de señalización utilizada, es diferente se…