6533b853fe1ef96bd12acc89

RESEARCH PRODUCT

Metabolite Sensing GPCRs: Promising Therapeutic Targets for Cancer Treatment?

Jesus Cosin-rogerSara CalatayudDolores Ortiz-masiáMaria D. Barrachina

subject

G-protein-coupled receptorMetaboliteReviewComputational biologyBiologyReceptors G-Protein-CoupledBile Acids and Saltschemistry.chemical_compoundNeoplasmsmetabolite sensing GPCRBiomarkers TumormedicinecancerAnimalsHumansMolecular Targeted TherapyAmino AcidsReceptorlcsh:QH301-705.5G protein-coupled receptorCell growthDisease ManagementCancerGeneral MedicineLipid Metabolismmedicine.diseaseCancer treatmentlcsh:Biology (General)Gene Expression RegulationchemistryHuman genomeDisease SusceptibilityCancer developmentEnergy MetabolismSignal Transduction

description

G-protein-coupled receptors constitute the most diverse and largest receptor family in the human genome, with approximately 800 different members identified. Given the well-known metabolic alterations in cancer development, we will focus specifically in the 19 G-protein-coupled receptors (GPCRs), which can be selectively activated by metabolites. These metabolite sensing GPCRs control crucial processes, such as cell proliferation, differentiation, migration, and survival after their activation. In the present review, we will describe the main functions of these metabolite sensing GPCRs and shed light on the benefits of their potential use as possible pharmacological targets for cancer treatment.

yearjournalcountryeditionlanguage
2020-10-01Cells
https://doi.org/10.3390/cells9112345