Search results for "PD"
showing 10 items of 1971 documents
Paternal uniparental disomy chromosome 14-like syndrome due a maternal de novo 160 kb deletion at the 14q32.2 region not encompassing the IG- and the…
2015
The human chromosome 14q32 carries a cluster of imprinted genes which include the paternally expressed genes (PEGs) DLK1 and RTL1, as well as the maternally expressed genes (MEGs) MEG3, RTL1as, and MEG8. PEGs and MEGs expression at the 14q32.2-imprinted region are regulated by two differentially methylated regions (DMRs): the IG-DMR and the MEG3-DMR, which are respectively methylated on the paternal and unmethylated on the maternal chromosome 14 in most cells. Genetic and epigenetic abnormalities affecting these imprinted gene clusters result in two different phenotypes currently known as maternal upd(14) syndrome and paternal upd(14) syndrome. However, only few patients carrying a maternal…
PPARβ activation restores the high glucose-induced impairment of insulin signalling in endothelial cells
2014
Background and Purpose PPARβ enhances insulin sensitivity in adipocytes and skeletal muscle cells, but its effects on insulin signalling in endothelial cells are not known. We analysed the effects of the PPARβ/δ (PPARβ) agonists, GW0742 and L165041, on impaired insulin signalling induced by high glucose in HUVECs and aortic and mesenteric arteries from diabetic rats. Experimental Approach Insulin-stimulated NO production, Akt-Ser 473 and eNOS-Ser 1177 phosphorylation, and reactive oxygen species (ROS) production were studied in HUVECs incubated in low- or high-glucose medium. Insulin-stimulated relaxations and protein phosphorylation in vessels from streptozotocin (STZ)-induced diabetic rat…
3 gadus vecu bērnu sociālo prasmju veicināšana pirmsskolas izglītības iestādē un sadarbībā ar ģimenēm
2019
Kvalifikācijas darba autore: Kristīne Liekna Kvalifikācijas darba nosaukums: 3 gadus vecu bērnu sociālo prasmju veicināšana pirmsskolas izglītības iestādē sadarbībā ar ģimenēm. Kvalifikācijas darba mērķis: Teorētiski un praktiski izpētīt sociālo prasmju veicināšanas nozīmi un iespējas 3 gadus vecu bērnu dzīvē pirmsskolas izglītības iestādē un sadarbībā ar ģimenēm. Darba teorētiskajā daļā atspoguļota sociālo prasmju definīcija, to iedalījums un klasifikācija, kā arī sociālo prasmju loma un vecumposma īpatnības 3 gadu veciem bērniem. Darba otrajā daļā ir apskatīta sociālo prasmju veicināšana ģimenē, kā arī vecāku un pedagogu sadarbības nozīme 3 gadus vecu bērnu sociālo prasmju veicināšanā. Be…
Salmeterol Xinafoate (SX) loaded into mucoadhesive solid lipid microparticles for COPD treatment
2019
Chronic obstructive pulmonary disease (COPD) is one of the main health problems worldwide. It is characterised by chronic inflammation in the lungs that leads to progressive, chronic, largely irreversible airflow obstruction. The use of long-acting β agonists remain today the frontline treatment for COPD with the aim of minimizing side effects and enhancing therapeutic usefulness. To this purpose, in this paper, mucoadhesive solid lipid microparticles (SLMs) containing a long-acting β-2 agonist, Salmeterol Xinafoate (SX) were prepared, characterised (size, z-potential, aerodynamic diameter, turbidimetric evaluations, drug loading and entrapping efficiency) and tested in a model of bronchial…
Sharp capacity estimates for annuli in weighted R^n and in metric spaces
2017
We obtain estimates for the nonlinear variational capacity of annuli in weighted R^n and in metric spaces. We introduce four different (pointwise) exponent sets, show that they all play fundamental roles for capacity estimates, and also demonstrate that whether an end point of an exponent set is attained or not is important. As a consequence of our estimates we obtain, for instance, criteria for points to have zero (resp. positive) capacity. Our discussion holds in rather general metric spaces, including Carnot groups and many manifolds, but it is just as relevant on weighted R^n. Indeed, to illustrate the sharpness of our estimates, we give several examples of radially weighted R^n, which …
Sistemi informativi 3D per i BB.CC. e l'archeologia: il Castello di Maredolce a Palermo
2014
Il mondo della ricerca nel campo dei BB.CC. sta guardando con sempre maggior interesse all’uso di tecnologie informatiche integrate, che consentano di fornire e condividere in rete dati quantitativi e qualitativi, geometrici, posizionali, alfanumerici, relativi ai BB.CC., sfruttando l’interazione tra banche dati e modelli 3D. Tali modelli, dunque, oltre a fornire una ricostruzione virtuale del monumento con la possibilità di navigare ed analizzare l’oggetto in dettaglio, costituiscono lo strumento per accedere ad informazioni eterogenee (testi, immagini, sequenze video, ecc.) sui manufatti, raccolte ed organizzate in database relazionali interrogabili, al fine di una piena comprensione e co…
Minimality via second variation for microphase separation of diblock copolymer melts
2017
Abstract We consider a non-local isoperimetric problem arising as the sharp interface limit of the Ohta–Kawasaki free energy introduced to model microphase separation of diblock copolymers. We perform a second order variational analysis that allows us to provide a quantitative second order minimality condition. We show that critical configurations with positive second variation are indeed strict local minimizers of the problem. Moreover, we provide, via a suitable quantitative inequality of isoperimetric type, an estimate of the deviation from minimality for configurations close to the minimum in the L 1 {L^{1}} -topology.
Site-specific DBCO modification of DEC205 antibody for polymer conjugation
2018
The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune system to combat tumour cells. In this work, we investigated the chemical attachment of DEC205 antibodies (aDEC205) as DC-targeting structures to polyplexes of P(Lys)-b-P(HPMA). The conjugation of a synthetic block copolymer and a biomacromolecule with various functionalities (aDEC205) requires bioorthogonal techniques to avoid side reactions. Click chemistry and in particular the strain-promoted alkyne-azide cycloaddition (SPAAC) can provide the req…
Non-autonomous rough semilinear PDEs and the multiplicative Sewing Lemma
2021
We investigate existence, uniqueness and regularity for local solutions of rough parabolic equations with subcritical noise of the form $du_t- L_tu_tdt= N(u_t)dt + \sum_{i = 1}^dF_i(u_t)d\mathbf X^i_t$ where $(L_t)_{t\in[0,T]}$ is a time-dependent family of unbounded operators acting on some scale of Banach spaces, while $\mathbf X\equiv(X,\mathbb X)$ is a two-step (non-necessarily geometric) rough path of H\"older regularity $\gamma >1/3.$ Besides dealing with non-autonomous evolution equations, our results also allow for unbounded operations in the noise term (up to some critical loss of regularity depending on that of the rough path $\mathbf X$). As a technical tool, we introduce a versi…
Anulación del privacy shield en las transferencias internacionales de datos : ¿presenciamos un desplazamiento fáctico de la responsabilidad?
2021
This study provides a comprehensive analysis of international transfers of personal data to third countries or international organizations due to new privacy regulation. More specifically, it analyzes the effects on this regulatory scheme of the annulment of the Privacy Shield in the transatlantic information movements between the European Union and the United States and how this implies, in fact, a transfer of responsibility to the controller