Search results for "PD"
showing 10 items of 1971 documents
The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline
2016
Abstract Background The German COPD cohort study COSYCONET (" CO PD and SY stemic consequences- CO morbidities NET work") investigates the interaction of lung disease, comorbidities and systemic inflammation. Recruitment took place from 2010 to 2013 in 31 study centers. In addition to the baseline visit, follow-up visits are scheduled at 6, 18, 36 and 54 months after baseline. The study also comprises a biobank, image bank, and includes health economic data. Here we describe the study design of COSYCONET and present baseline data of our COPD cohort. Methods Inclusion criteria were broad in order to cover a wide range of patterns of the disease. In each visit, patients undergo a large panel …
FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study.
2017
Abstract Background Lung function has previously been related to increased mortality. Whether pulmonary impairment is associated with an increased mortality independent of cardiac dysfunction remains unclear. Methods In 15010 individuals from the general population (age range 35–74years, 51% men) in the Gutenberg Health Study we performed spirometry and transthoracic echocardiography. N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (hsTnI) were measured in all individuals. 1819 individuals with pulmonary diseases were excluded from further analysis. Results The median for forced expiratory volume in 1s (FEV1) was 94.2% and for forced vital capacity (FVC) …
Association between nasal and bronchial resistance in patients with COPD
2018
Background: During the past decade, various studies have documented the presence of sinonasal inflammation in lower airways diseases. The influence of airways inflammation on nasal airways patency was demonstrated in asthmatic patients; however, such association was not confirmed in patients with COPD. Purpose: The aim of the study was to compare the relationship between nasal resistance and lower airways patency in COPD patients and healthy controls. Material and Methods: 4-Phase-Rhinomanometry and spirometry were performed on COPD patients (n=26) and in the corresponding age control group (n=15). To compare the effective nasal resistance in inspiration, expiration and total breathing (Ref…
Small airway disease (SAD) is associated with respiratory symptoms and relevant for therapy in early COPD
2020
Background: SAD is common in patients with COPD. Occurring early in the course of the disease, it is frequently missed by currently used diagnostic tests. Multiple breath washout (MBW) testing detects ventilation heterogeneity (VH) while oscillometry (OS) assesses peripheral obstruction, both associated with SAD. We therefore set out to evaluate the presence and symptoms of SAD in patients with early COPD. Methods: We prospectively evaluated 26 patients (FEV1 77±19% pred., 88% GOLD I/II). In an 8-week cross-over design, the effect of dual bronchodilatation (tiotropium/olodaterol, T/O) on lung function and symptoms (CAT) was compared to monotherapy (formoterol). Lung function was assessed by…
The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography.
2008
In patients with mild chronic obstructive pulmonary disease (COPD), the effect of deep inspirations (DIs) to reverse methacholine-induced bronchoconstriction is largely attenuated. In this study, we tested the hypothesis that the effectiveness of DI is reduced with increasing disease severity and that this is associated with a reduction in the ability of DI to distend the airways. Fifteen subjects [Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage I–II: n = 7; GOLD stage III–IV: n = 8] underwent methacholine bronchoprovocation in the absence of DI, followed by DI. The effectiveness of DI was assessed by their ability to improve inspiratory vital capacity and forced expira…
Pathophysiological Factors in the Relationship between Chronological Age and Calculated Lung Age as Detected in a Screening Setting in Community-Dwel…
2016
Aim To explore the relationship between pathophysiological factors and premature lung aging in a cohort of community-dwelling subjects in a health-screening setting. Methods 16,107 pharmacy customers in Germany (5954 males, 10,153 females; mean age 59.7 years) participated in a lung function screening project by providing demographic data, including smoking status and known airway conditions and performing spirometry with a Vitalograph, a spirometry screening device. Lung age was calculated from the spirometric findings, and the difference between chronological age and calculated lung age was analyzed in its relationship to the demographic data in general linear models. Results In the overa…
Chronic obstructive pulmonary disease in severe mental illness: A timely diagnosis to advance the process of quitting smoking
2021
This study receives founding by the Spanish Ministry of Economy, Industry, and Competitiveness, Instituto Carlos III (FIS PI16/00802).
Strengthened splitting methods for computing resolvents
2021
In this work, we develop a systematic framework for computing the resolvent of the sum of two or more monotone operators which only activates each operator in the sum individually. The key tool in the development of this framework is the notion of the “strengthening” of a set-valued operator, which can be viewed as a type of regularisation that preserves computational tractability. After deriving a number of iterative schemes through this framework, we demonstrate their application to best approximation problems, image denoising and elliptic PDEs. FJAA and RC were partially supported by the Ministry of Science, Innovation and Universities of Spain and the European Regional Development Fund …
Mācību projekti valodas prasmju un motivācijas attīstībai vācu valodas stundās 10. un 11. klasei
2021
Diplomdarbā tiek pētīts, kā mācību projektu izmantošana svešvalodu stundās veicina mācību stundu daudzveidību un paaugstina skolēnu motivāciju. Darba ievadā tiek formulēts mērķis, uzdevumi un hipotēze. Teorētiskajā daļā tiek pētīti jautājumi, kas pamato mācību projekta izmantošanu. Darba gaitā tika apskatītas terminu definīcijas – mācību motivācija, vissvarīgākās mācību projektu iezīmes un veidi, tēmu dažādības iespējas un idejas mācību projektiem, kā arī starpdisciplināri mācību projekti un to nozīme vācu valodas stundās. Diplomdarba praktiskajā daļā tiek izmantota gadījuma pētījuma metode. Pedagoģis-kā pētījuma mērķa grupa ir 10. klase. Svešvalodu prasmes līmenis: vispārējais līmenis (B1)…
Attālinātā mācību procesa nodrošināšana mācību tēmā "Svinību organizēšana un plānošana" dizainā un tehnoloģijās 8. klasē
2021
Diplomdarba mērķis ir izpētīt attālinātā mācību procesa nodrošināšanas iespējas mācību tēmā “Svinību organizēšana un plānošana” dizainā un tehnoloģijās 8. klasē. Darba teorētiskajā daļā tiek raksturots attālinātais mācību process un tehniskie risinājumi. Aplūkotas Latvijas, Zviedrijas, Igaunijas un Somijas pieredzes attālināto mācību organizēšanā. Aprakstīta svinību organizēšana un reglamentējošie dokumenti 8. klases mācību saturam dizainā un tehnoloģijās. Praktiskajā daļā izstrādāts starpdisciplinārs tematiskais plāns mācību satura attālinātai apgūšanai dizainā un tehnoloģijās 8. klasē, tika analizēti iegūtie rezultāti un veikta aprobācija. Atspoguļoti dizaina un tehnoloģiju pedagogu piere…