Search results for "PD"

showing 10 items of 1971 documents

Starpdisciplinaritāte sociālajās zinātnēs: vai tā sniedz atbildes uz mūsdienu izaicinājumiem augstākajā izglītībā un pētniecībā?

2012

Eiropas Komisijas pārstāvniecība Latvijā, Latvijas Universitāte

:INTERDISCIPLINARY RESEARCH AREAS [Research Subject Categories]IzglītībaDemogrāfijaSociālajās zinātnes:SOCIAL SCIENCES [Research Subject Categories]Starpdisciplinārie pētījumi
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The effects of movement and spatial activities on real and imagined spatial updating: Poster

2021

:NATURAL SCIENCES [Research Subject Categories]imagined movementmovement expertsspatial updating
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La gamificación como estrategia metodológica para la inclusión en Educación Primaria

2020

Una de las necesidades fundamentales de la educación actual es proporcionar un aprendizaje inclusivo y adaptado al alumnado que presenta Necesidades Específicas de Apoyo Educativo (NEAE). En este propósito, ocupa un papel muy importante la estrategia metodológica que se emplea en el proceso de enseñanza y aprendizaje. Ya que cada vez son más notables las carencias de modelos educativos que buscan enseñar los mismos contenidos, de la misma manera, pero a alumnado muy diverso. Por este motivo, en esta investigación se va analizar una estrategia metodológica relativamente novedosa, la gamificación, que se define como el uso de mecánicas, estéticas y elementos propios del diseño de juegos con e…

:PSICOLOGÍA::Psicopedagogía::Métodos educativos [UNESCO]inclusión educativagamificación:PEDAGOGÍA [UNESCO]necesidades específicas de apoyo educativoUNESCO::PSICOLOGÍA::Psicopedagogía::Métodos educativospducación primariainnovación metodológicaUNESCO::PEDAGOGÍA
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Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo

2021

Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…

ABCC1 ATP binding cassette subfamily C member 1IC50 half maximal inhibitory concentrationMultidrug resistancePharmacologyNADPH reduced nicotinamide adenine dinucleotide phosphateF bioavailabilitychemistry.chemical_compoundPCR polymerase chain reaction0302 clinical medicineMDR multidrug resistanceECL electrochemiluminescencet1/2 elimination half-lifeLC–MS liquid chromatography coupled with mass spectrometryN.D. not detectedGeneral Pharmacology Toxicology and PharmaceuticsBBB blood–brain barriermedia_commonATF3 activating transcription factor 30303 health sciencesChemistryABC ATP-binding cassetteNMPA National Medical Products AdministrationPXR pregnane X receptorSDS-PAGE sodium dodecyl sulfate-polyacrylamide gel electrophoresisHBSS Hankʹs balanced salt solutionABCB1Combination chemotherapyProdrugMarsdenia tenacissimaCmax peak concentrationPaclitaxelGAPDH glyceraldehyde-3-phosphate dehydrogenase030220 oncology & carcinogenesisBHI brain heart infusionOriginal ArticleAUC0–∞ area under plasma concentration vs. time curveMRT mean residence timeDrugmedia_common.quotation_subjectRM1-950Vd volume of distributionABCB1 ATP binding cassette subfamily B member 1UIC-2 mouse monoclonal ABCB1 antibodyABCG2 ATP binding cassette subfamily G member 2Combination chemotherapyCYP cytochrome P450 isozymePI propidium iodideTEER transepithelial electrical resistance03 medical and health sciencesPBS phosphate buffer salineFBS fetal bovine serumDox doxorubicinIn vivoPOP polyoxypregnanemedicine030304 developmental biologyEVOM epithelial tissue voltohmmeterTmax time for peak concentrationCancerLBE lowest binding energyPE phycoerythrinmedicine.diseaseMultiple drug resistancePolyoxypregnanePapp apparent permeabilityN.A. not applicableCancer cellH&E hematoxylin and eosinMDR1a multidrug resistance protein 1aTherapeutics. PharmacologyqPCR quantitative PCRM. tenacissima Marsdenia tenacissimaCL clearanceSD standard derivationActa Pharmaceutica Sinica B
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ROLE OF SMADS IN REMODELLING OF THE LARGE AIRWAYS IN PATIENTS WITH COPD.

2011

AIRWAYSSettore BIO/16 - Anatomia UmanaCOPDSMADS
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Anodic alumina membranes modified by electroless deposition of Pd and Ni

2006

ALUMINA MEMBRANE Pd Ni Electroless
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Sāpju vadīšana pediatriskiem pacientiem apdeguma gadījumā

2019

Bakalaura darba tēma – Sāpju vadīšana pediatriskiem pacientiem apdegumu gadījumā. Šī tēma ir aktuāla, jo statistika liecina, ka katru gadu bērnu apdegumu skaits arvien pieaug. Salīdzinot 2016. gada un 2017. gada datus, apdegumu skaits bērnu vidu pieaudzis par septiņiem gadījumiem. Lielākā riska grupa apdegumu traumām ir bērni vecuma posmā no trīs gadu vecuma, kas applaucējumus vairumā iegūst vecāku neuzmanības dēļ. Darba izstrādāšanas mērķis – Noskaidrot sāpju vadīšanas principus pediatriskiem pacientiem apdegumu gadījumā. Darba uzdevumi ir izanalizēt un apkopot iegūtos datus par sāpju vadīšanas principiem pediatriskiem pacientiem apdegumu gadījumā. Analizēt Virdžīnijas Hendersones māszinīb…

APDEGUMINOVĒRTĒŠANAATSĀPINĀŠANASĀPJU VADĪŠANAPEDIATRIJAMedicīna
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Bērns ar individualām īpatnībam pedagoģiskājā procesā pirmsskolā

2018

Bakalaura darbs izstrādāts par tēmu „Bērns ar individuālām īpatnībām pedagoģiskajā procesā pirmsskolā”. Pētījuma aktualitāti noteica izmaiņas mūsdienu skatījumā uz tādiem bērniem, turklāt daudzas ģimenes un audzinatājas nezin, kā pareizi rīkoties un strādāt šādā situācijā. Darba mērķis ir noteikt darbam ar tādiem bērniem atbilstošas pedagoģiskās darbības pirmsskolas pedagoģiskajā procesā. Pētījums sastāv no 2 daļām – teorētiskās un praktiskās. Teorētiskajā daļā analizēti tādi jautājumi kā apdāvinātības problēma pedagoģijā un psiholoģijā, izskatot tādu autoru pētījumus kā V.Bļinova, K.Hellers, Šumakova u.c. Plaši pētīta pedagoģisko metožu izmantošana izglītojošajā darbā ar pirmsskolas vecuma…

APDĀVINĀTĪBAINDIVIDUĀLA PIEEJABĒRNSPEDAGOGSTĒLOTĀJDARBĪBASkolas pedagoģija
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Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre1…

2021

Purpose: To investigate the possible association between ventilatory settings on the first day of invasive mechanical ventilation (IMV) and mortality in patients admitted to the intensive care unit (ICU) with severe acute respiratory infection (SARI). Materials and methods: In this pre-planned sub-study of a prospective, multicentre observational study, 441 patients with SARI who received controlled IMV during the ICU stay were included in the analysis. Results: ICU and hospital mortality rates were 23.1 and 28.1%, respectively. In multivariable analysis, tidal volume and respiratory rate on the first day of IMV were not associated with an increased risk of death; however, higher driving pr…

ARDSSoins intensifs réanimationmedicine.medical_treatmentAirway pressuresPEEP positive end-expiratory pressureCritical Care and Intensive Care Medicinelaw.inventionHypoxemiaCohort StudiesPositive-Pressure RespirationMechanical ventilationSARI severe acute respiratory infectionlawHospital MortalityProspective StudiesIQR interquartile rangesProspective cohort studyRCT randomized controlled trialTidal volumeSOFA Sequential Organ Failure AssessmentSAPS Simplified Acute Physiology ScoreIntensive care unitVCV volume-controlled ventilationHIV human immunodeficiency virusIntensive Care UnitsIC GLOSSARI Intensive Care Global Study on Severe Acute Respiratory Infectionmedicine.symptomCohort studyLOS length of staymedicine.medical_specialtyVt tidal volumeCOPD Chronic obstructive pulmonary diseaseNYHA New York Heart Association.PCV pressure-controlled ventilationArticleInternal medicineICU Intensive Care UnitSIMV Synchronized intermittent mandatory ventilationmedicineTidal VolumeHumansDP driving pressurePEEPARDS acute respiratory distress syndromeMechanical ventilationbusiness.industryOdds ratioPneumoniaPlateau pressuremedicine.diseaseRespiration ArtificialVILI ventilator induced lung injuryCI confidence intervalOR odds ratioIMV invasive mechanical ventilationCPAP continuous positive airway pressureARDSbusinessSD standard deviationECMO extracorporeal membrane oxygenationPBW predicted body weightPplat plateau pressure
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics

2021

Graphical abstract

ATP Adenosine-triphosphateNBD nucleotide binding domainGSH reduced glutathionePolypharmacologyAlzheimer’s disease (AD)ATP-binding cassette transporterHTS high-throughput screeningBiochemistryABCA7Structural BiologyPLIF protein ligand interactionMSD membrane spanning domainPDB protein data bankTM transmembrane helixABC ATP-binding cassetteMultitarget modulation (PANABC)RMSD root mean square distanceABC transporter (ABCA1 ABCA4 ABCA7)Computer Science ApplicationsMOE Molecular Operating EnvironmentPharmacophoreSNP single-nucleotide polymorphismBiotechnologyResearch ArticleBBB blood-brain barrierBiophysicsDrug designComputational biologyBiologyAD Alzheimer’s diseasePET positron emission tomographyIC intracellular helixAPP amyloid precursor proteincryo-EM cryogenic-electron microscopyGeneticsHomology modelingBinding siteRational drug design and developmentComputingMethodologies_COMPUTERGRAPHICSNBD-cholesterol 7-nitro-2-13-benzoxadiazol-4-yl-cholesterolTransporterPSO particle swarm optimizationPET tracer (PETABC)ECD extracellular domainR-domain/region regulatory domain/regionABCA1biology.proteinEH extracellular helixTP248.13-248.65BODIPY-cholesterol 44-difluoro-4-bora-3a4a-diaza-s-indacene-cholesterolComputational and Structural Biotechnology Journal
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