Search results for "PD"
showing 10 items of 1971 documents
Late Breaking Abstract - Dose-ranging study of mepolizumab in eosinophilic COPD
2018
Background: Patients with eosinophilic COPD & frequent exacerbations may benefit from mepolizumab (MEP) treatment. Objective: Assess efficacy & safety of 2 MEP doses vs placebo (PBO) in COPD with blood eosinophils ≥150 cells/µL [screening] or ≥300 cells/µL [prior yr], history of ≥2 moderate/≥1 severe exacerbations & ICS+≥2 bronchodilator maintenance therapies (ICS+MT). Methods: Phase III, randomised, PBO-controlled, double-blind, parallel-group trial (METREO); patients received SC MEP 100mg, MEP 300mg or PBO plus ICS+MT, every 4 wks for 52 wks. Primary endpoint: rate/yr of moderate (systemic corticosteroids/antibiotics)/severe(hospitalisation or death) exacerbations. Secondary endpoints inc…
Elektronisko parakstu īstenošana PDF dokumentos
2015
Šis darbs apskata elektronisko parakstu īstenošanu PDF dokumentos. Tas pēta elektronisko parakstu struktūru un funkcionalitāti. Darba mērķis ir izpētīt elektronisko parakstu standartus PDF dokumentiem, struktūru, darbības principus un īstenošanas iespējas. Uzmanība tiek pievērsta pakarstu struktūrai, un ir apskatīti nepieciešamie dati elektronisko parakstu veidošanai. Tiek izpētīti papildus procesi un servisi, kurus ir nepieciešams nodrošināt elektronisko parakstu sniedzēju pusē. Papildus tiek apskatīti dažu elektronisko parakstu sniedzēju produkti. Darbā tiek aprakstīta tīmekļa lietotnes veidošana, kas nodarbojas ar parakstu pievienošanu un parakstu pārbaudi PDF dokumentos. Tiek parādīts, …
Summary of Week VII
2018
International audience; Week VII of the INT program 2018 “Probing Nucleons and Nuclei in High Energy Collisions” was dedicated to topics at the interface of the electron-ion collider (EIC), heavy ion and proton-nucleus collisions. The EIC will provide complementary tools to investigate and constrain the initial state in HIC collisions, as well as transport properties of QCD matter which can be extracted from observables that are sensitive to final states interactions such as pt-broadening and energy loss. The contributed talks and discussions covered a variety of physics topics from saturation physics and the origin of multi-particle correlations in HIC to jet quenching and the strong coupl…
MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation
2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used. In our recent studies, we identified two miRNAs as regulators of hMSCs osteoblast differentiation driving hypoxia signaling and cytoskeletal reorganization. Other signalings involved in this process are epithelial to mesenchymal transition (EMT) and epidermal growth factor receptor (EGFR) signalings through the regulation of Yes-associated protein (YAP)/PDZ-binding motif (TAZ) expression. In the current study, we investigated the role of miR-33a family as a (…
Convergence of dynamic programming principles for the $p$-Laplacian
2018
We provide a unified strategy to show that solutions of dynamic programming principles associated to the $p$-Laplacian converge to the solution of the corresponding Dirichlet problem. Our approach includes all previously known cases for continuous and discrete dynamic programming principles, provides new results, and gives a convergence proof free of probability arguments.
Comparación del Vitalograph COPD-6® y del Air Smart Spirometer® con la espirometría estándar en el despistaje y el diagnóstico de los pacientes con E…
2020
La enfermedad pulmonar obstructiva crónica (EPOC) está infradiagnosticada aunque mejora su evo- lución y pronóstico si se trata precozmente y su principal tratamiento es la abstinencia tabáquica. El objetivo principal de este estudio es comparar los espirómetros de campo COPD-6 ® (Vitalograph) y Air Smart Spirometer® con la espirometría estándar en el diagnóstico de la obstrucción bronquial. Los objetivos secundarios son: determinar cuál de los dos espirómetros estudiados es más eficaz y/o eficiente; detectar los falsos positivos que generan y valorar su aportación a la deshabituación tabá- quica. Participaron 185 pacientes del Centro de Salud Fuensanta con o sin síntomas o signos sugestivo…
Chemical characterization of Anthemis parlatoreana fresh and dried aerial parts by GC and LC chromatographic techniques and evaluation of the antioxi…
2022
Anthemis parlatoreana was collected in the north west coast of Sicily. Fresh and dried aerial parts were subjected to distillation procedure for the extraction and isolation of essential oils. In both fresh and dried samples, the most abundant chemical classes were ketones and esters, represented to a greater extent by β-thujone and β-artemisia acetate, respectively. In dried vegetable material, a high content of α-pinene and δ3-carene was also registered. Aqueous, methanol and ethyl acetate extracts of aerial parts were also investigated in terms of polyphenolic content and antioxidant potential. All the extracts tested showed a quite different quali-quantitative profile and in terms of ch…
AAS "Balta" darbības analīze
2017
Latvijas apdrošināšanas tirgū ir apdrošināšanas kompāniju pārblīvējums, kā rezultātā ir augsta konkurence un daļa no vadošajiem apdrošinātājiem strādā ar zaudējumiem.Bakalaura darba mērķis ir, pamatojoties uz AAS “BALTA” un vadošo Latvijas apdrošinātāju darbības datu analīzes pamata, identificēt AAS “BALTA” zaudējumu nesošos posmus un izstrādāt priekšlikumus to novēršanai. Lai sasniegtu darba mērķi, tiek pētīta Latvijas likumdošana, analizēta AAS “BALTA” struktūra, riska vadība un administratīvo izdevumu sadaļa. Autors secina, ka AAS “BALTA” pilnveidojot struktūru, investējot IT un pārskatot darbinieku darba uzdevumus var sasniegt peļņu, nemainot pakalpojuma izcenojumus.
Inverse problems and invisibility cloaking for FEM models and resistor networks
2013
In this paper we consider inverse problems for resistor networks and for models obtained via the finite element method (FEM) for the conductivity equation. These correspond to discrete versions of the inverse conductivity problem of Calderón. We characterize FEM models corresponding to a given triangulation of the domain that are equivalent to certain resistor networks, and apply the results to study nonuniqueness of the discrete inverse problem. It turns out that the degree of nonuniqueness for the discrete problem is larger than the one for the partial differential equation. We also study invisibility cloaking for FEM models, and show how an arbitrary body can be surrounded with a layer …
Il valore delle differenze. Tipicità e terroir nella cultura alimentare
2021
DOP, IGP, tipico, tradizionale, a chilometro zero, terroir, identità: negli ultimi decenni il cibo è entrato prepotentemente nelle nostre vite come fenomeno geografico e sociale, ancor prima che alimentare. Questo lavoro propone un’analisi semiotica del fenomeno attraverso quattro casi emblematici di costruzione della tipicità alimentare: quello del sistema dei marchi di qualità europei DOP, IGP e STG e del problema dell’origine; quello di un relais in Sicilia dove l’esperienza di permanenza è incentrata sull’apprendimento della cucina tradizionale; quello del linguaggio dei ristoranti “stellati” e della loro evoluzione – ormai d’obbligo – in templi dell’alta cucina locale; quello relativo …