Search results for "PD"
showing 10 items of 1971 documents
The CFTR associated protein CAP70 interacts with the apical Cl-/HCO3- exchanger DRA in rabbit small intestinal mucosa.
2005
DRA (down regulated in adenoma) is an intestinal anion exchanger, acting in parallel with NHE3 to facilitate ileal and colonic NaCl absorption. Furthermore it is involved in small intestinal bicarbonate secretion. Because DRA has a PDZ interaction motif, which may influence its properties, we searched for DRA-interacting PDZ adapter proteins in the small intestine. Using an overlay assay with the recombinant DRA C-terminus as a ligand, a 70 kDa protein was labeled, which was restricted to the brush border membrane in rabbit duodenal and ileal mucosa and was not detected in the colon. Destruction of the C-terminal PDZ interaction motif abolished this band, suggesting a specific protein-prote…
Differences in the efficacy and safety among inhaled corticosteroids (ICS)/long-acting beta2-agonists (LABA) combinations in the treatment of chronic…
2015
Inhaled corticosteroids (ICS) are frequently recommended for the treatment of asthma and COPD, often in combination with long-acting beta2-agonists (LABA), depending on the severity of the disease and/or on the specific phenotype. Several ICS/LABA combinations are currently available that differ in their pharmacokinetic characteristics and dose of both components. Thus, this review assesses differences in the efficacy and the safety profiles of the ICS components in the two more frequently used ICS/LABA combinations (budesonide/formoterol and fluticasone/salmeterol) for the management of COPD. Whereas the basic mechanism of action is similar for all ICS (binding with the intracellular gluco…
Budesonide/formoterol for the treatment of asthma.
2003
Budesonide/formoterol (Symbicort), AstraZeneca plc) is a novel treatment for asthma, combining an inhaled corticosteroid - budesonide, and a long-acting beta(2)-agonist - formoterol, in a single inhaler, the Turbuhaler. Randomised, clinical studies in patients with asthma have demonstrated that budesonide/formoterol is more effective than the inhaled corticosteroids, budesonide and fluticasone alone, and at least as effective as both monocomponents in separate inhalers. Results from clinical studies suggest a synergistic effect when both drugs are administered via one inhaler, although the mechanisms for this are not fully understood. Budesonide/formoterol has a rapid onset of effect, appar…
Safety Considerations of Inhaled Corticosteroids in the Elderly
2014
Inhaled corticosteroids (ICSs) are widely used in the treatment of patients with chronic obstructive pulmonary diseases. However, high-dose regimens and long-term use of ICSs have the potential to cause a variety of local and systemic side effects such as candidiasis, cataracts, glaucoma, and osteoporosis. The use of ICSs can also be associated with the risk of bone fractures, diabetes mellitus and pneumonia. These ICS-related side effects are of particular importance in elderly patients due to the presence of comorbidities and age-related behavioral, cognitive, and psychological problems, which can all interact with inhaled treatment. We reviewed the available literature on the clinically …
Burtveidolu kompozīcijas kā grafiskās izteiksmes līdzeklis
2017
Burtu nozīme dizainā ir nenoliedzami milzīga. Bieži vien tas ir svarīgākais elements dizaina projektā. Dizaineri iegulda daudz laika un darba, lai burtveidolus padarītu viegli uztveramus. Burtus pielieto ne tikai, lai nodotu informāciju avīzēs, grāmatās, žurnālos vai plakātos. No tiem var veidot kompozīcijas, kurās interesanta dizaina burti pastiprina teksta vēstījumu. Šobrīd t-krekls ir viens no plašāk izmantotajiem apģērba gabaliem tāpēc ir sastopami daudzi kreklu piemēri ar interesantām ilustrācijām, bet autore domā, ka ir nepieciešams vairāk t-kreklu, kuros tiktu pielietotas zīmētas burtu kompozīcijas. Bakalaura darba mērķis ir izpētīt burtveidolus un izveidot zīmētas burtu kompozīcijas…
PDE triangular Bézier surfaces: Harmonic, biharmonic and isotropic surfaces
2011
We approach surface design by solving second-order and fourth-order Partial Differential Equations (PDEs). We present many methods for designing triangular Bézier PDE surfaces given different sets of prescribed control points and including the special cases of harmonic and biharmonic surfaces. Moreover, we introduce and study a second-order and a fourth-order symmetric operator to overcome the anisotropy drawback of the harmonic and biharmonic operators over triangular Bézier surfaces. © 2010 Elsevier B.V. All rights reserved.
A third order partial differential equation for isotropic boundary based triangular Bézier surface generation
2011
Abstract We approach surface design by solving a linear third order Partial Differential Equation (PDE). We present an explicit polynomial solution method for triangular Bezier PDE surface generation characterized by a boundary configuration. The third order PDE comes from a symmetric operator defined here to overcome the anisotropy drawback of any operator over triangular Bezier surfaces.
Explicit Bézier control net of a PDE surface
2017
The PDE under study here is a general fourth-order linear elliptic Partial Differential Equation. Having prescribed the boundary control points, we provide the explicit expression of the whole control net of the associated PDE Bézier surface. In other words, we obtain the explicit expressions of the interior control points as linear combinations of free boundary control points. The set of scalar coefficients of these combinations works like a mould for PDE surfaces. Thus, once this mould has been computed for a given degree, real-time manipulation of the resulting surfaces becomes possible by modifying the prescribed information. The work was partially supported by Spanish Ministry of Econo…
Laboratorisko iekaisuma marķieru prognostiskā nozīme nozokomiālās infekcijas diagnostikā smagas termiskas apdeguma traumas pacientam
2017
Darba pamatojums. Zelta standarts intrahospitālās infekcijas un sepses diagnostikā, pacientiem ar apdeguma traumu, vēl joprojām balstās uz mikrobioloģisko izmeklēšanu, kura var aizkavēt antibakteriālas terapijas uzsākšanas laiku. Līdz ar to ir mērķtiecīgi atrast prognostisko faktoru, kurš var agrīni norādīt uz intrahospitālas infekcijas attīstību, pacientiem ar smagu apdeguma traumu. Izvirzītā hipotēze: laboratoriskie radītāji var agrīni norādīt uz draudošo intrahospitālas infekcijas attīstību, pacientiem ar smagu termisku apdeguma traumu. Materiāli un metodes. Pētījums norisinājās RAKUS stacionārā “Biķernieki”, Valsts apdeguma centrā. Pētījumā tika iekļauti pacienti, kuri guvuši smagu term…
Spirometric criteria to diagnose airway obstruction in the elderly: fixed ratio vs. lower limit of normal.
2015
COPD is the most common chronic lung disease. It becomes more prevalent with increasing age but remains under-diagnosed in the elderly. A heated debate concerns the most suitable way to diagnose airway obstruction in this age group. Most COPD guidelines recommend to use a FEV1/FVC of 0.70 as threshold to define an obstructive ventilatory defect. While the use of a 0.70 ratio may be simple, it may result in under-diagnosis of airflow obstruction in young people and over-diagnosis in the elderly due to an age-related decline in pulmonary volumes, especially in FEV1. This might lead to unnecessary use of medications and increased risk of adverse effects. A proposed strategy for reducing the mi…