Search results for "PD"
showing 10 items of 1971 documents
Effects of the MDM2 inhibitor Nutlin-3a on sensitivity of pancreatic cancer cells to berberine and modified berberines in the presence and absence of…
2021
Abstract Approaches to improve pancreatic cancer therapy are essential as this disease has a very bleak outcome. Approximately 80% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC). A key regulatory gene frequently mutated (∼75%) in PDAC is the TP53 tumor suppressor gene which controls the transcription of multiple genes involved in cell cycle progression, apoptosis, cancer progression and other growth regulatory processes. The mouse double minute 2 homolog (MDM2) gene product is a nuclear-localized E3 ubiquitin ligase and negatively regulates the TP53 protein which results in its proteasomal degradation. Various MDM2 inhibitors have been isolated and examined in clinical t…
Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life
2021
Abstract Background and aims Severe asthma is burdened by frequent exacerbations and use of oral corticosteroids (OCS) which worsen patients’ health and increase healthcare spending. Aim of this study was to assess the clinical and economic effect of adding mepolizumab (MEP) for the treatment of these patients. Methods Patients >18 years old, referred to 8 asthma clinics, starting MEP between May 2017 and December 2018, were enrolled and followed-up for 12 months. Information in the 12 months before mepolizumab were collected retrospectively. The evaluation parameters included: OCS use, number of exacerbations/hospitalizations, concomitant therapies, comorbidity, and annual number of workin…
Compliance to ventilatory treatment in a cohort of patients on home CPAP or NIV: analysis by diagnosis, treatment type, and comorbidities
2019
Background: Patients on home continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) show large variability in compliance to treatment. Aim: To identify predictors of poor compliance, we evaluated compliance to treatment in patients with obstructive sleep apnea (OSA), obesity hypoventilation syndrome (OHS), and OSA-chronic obstructive pulmonary disease (COPD) overlap syndrome. Methods: We analyzed clinical and compliance data provided by a single home care provider, in 602 patients (n=442 OSA, males (M) 308; 38 OHS M=15, and 122 overlap M=111) on home CPAP/NIV in the province of Agrigento, Italy, after one year of treatment. The following variables were considered: age, …
Ceļš uz obligāto veselības apdrošināšanas ieviešanu Latvijā
2016
Bakalaura darba tēma - „Ceļš uz obligātās veselības apdrošināšanas ieviešanu Latvijā” tika izvēlēta, jo veselības aprūpes nozare Latvijā ir nesakārtota un tai ir nepieciešamas pārmaiņas, kā iespējamā variantā ieviešot obligāto veselības apdrošināšanu. Darbā tiek raksturots šobrīd valstī pastāvošais veselības aprūpes finansējums, analizēta obligātā veselības apdrošināšana kā tāda, pētīta obligātā veselības apdrošināšana citās valstīs un meklētas problēmas, kas liedz obligāto veselības apdrošināšanu ieviest Latvijā. Darba mērķis ir balstoties uz pieejamo literatūru, publikācijām un normatīvajiem aktiem, identificēt nozīmīgākās problēmas, kas traucē ieviest obligāto veselības apdrošināšanu Lat…
Zobārstu pilnā vainaga preparātu konverģences pārbaude Latvijā, laboratorijas pētījums
2020
Ievads: Vienas vienības kroņa vai fiksētas daļējas protēzes saglabāšana un pretestība ir divi mehāniski faktori, kas ir saistīti ar veiktās atjaunošanas prognozi. Publicētajā literatūrā tiek atbalstīti īpaši zoba sagatavošanas parametri kroņa uzlikšanai. Preparācijas vertikālajām sienām jābūt ar konverģences leņķi no 10-14 grādiem, lai nodrošinātu kroņa saglabāšanu. Šo parametru neievērošana rada lielāku risku zaudēt kroņa saglabāšanu. Tomēr pētījumi liecina, ka šie kritēriji parasti netiek ievēroti. Nespēja ierobežot vertikālās sienas konverģenci (kopējo okluzālo konverģenci) izraisa protēzes struktūras zudumu, kariesu, palielina zobu struktūras zūdumu preparēšanas laikā un samazinā zoba p…
Characterization of chronic obstructive pulmonary disease in dairy farmers
2020
International audience; Background - Although farming is often considered a risk factor for COPD, data regarding the burden and characteristics of COPD in dairy farmers are sparse and conflicting. Objectives - To characterize COPD in dairy farmers. Methods - 4788 subjects entered two parallel COPD screening programs, one in agricultural workers and one in general practice from 2011 to 2015. Subjects with COPD were invited to participate in the characterization phase of the study. Those who accepted were included in two subgroups: dairy farmers with COPD (DF-COPD) (n = 101) and non-farmers with COPD (NF-COPD) (n = 85). Patients with COPD were frequency-matched with subjects with normal spiro…
Occurrence of fourteen mycotoxins in tiger-nuts
2012
Abstract A previous developed matrix solid-phase dispersion (MSPD) extraction method was applied for the routine analysis of aflatoxins (AFs), ochratoxin A (OTA), fumonisins (FB 1 and FB 2 ), beauvericin (BEA), nivalenol (NIV), deoxynivalenol (DON), the toxin T-2 (T-2), toxin HT-2 (HT-2), diacetoxyscirpenol (DAS) and zearalenone (ZEN) in tiger-nuts by liquid chromatography–triple-quadrupole linear ion trap (HPLC–QTRAP ® ). The extraction solid support used was C 18 , while the elution solvent was acetonitrile/methanol (50/50, v/v) 1 mM ammonium formate. Using matrix-matched calibration, recoveries and repeatabilities were in the range 67–89% and 2–11% relative standard deviation (RSD), resp…
Evaluation of matrix solid-phase dispersion (MSPD) extraction for multi-mycotoxin determination in different flours using LC-MS/MS
2011
An existing matrix solid-phase dispersion (MSPD) method for aflatoxins (AFs) and ochratoxin A (OTA) extraction was extended by further 14 mycotoxins. After it careful optimization, this method was applied to determine the occurrence of these mycotoxins on commercial flour samples (with different cereals composition) collected from local markets. In a total of 49 samples investigated, 9 mycotoxins were identified. Nivalenol (NIV) and Beauvericin (BEA) were the mycotoxins found most frequently. The samples that presented major contamination were wheat flours and bakery preparations. Despite of the great number of positives finding, only one wheat flour sample exceeded the maximum limits (ML) …
Síndrome de Cockayne: Informe de un caso: revisión de la literatura
2006
El Síndrome de Cockayne (CS) es un desorden genético con un patrón de herencia autosómico recesivo que fue descrito por primera vez en 1936 por Cockayne. Los pacientes con este síndrome presentan detención del crecimiento, talla baja, envejecimiento prematuro, anormalidades neurológicas, fotosensibilidad, retraso en la erupción de los dientes primarios, ausencia congénita de dientes permanentes, macrodoncia parcial, atrofia de los procesos alveolares y caries dental. Puede ser causado por mutación en dos genes, el CKN1 (ERCC8) y el ERCC6, localizados en los cromosomas 5 y 10 respectivamente; originando dos tipos: CS-A que tienen mutación en ERCC8 y CS-B con mutación en ERCC6, este último pr…
Uzņēmumu “DPD” un “Omniva” komunikācijas analīze sociālajos medijos “Facebook” un “Instagram” 2020. - 2021. gadā
2022
Bakalaura darba “Uzņēmumu “DPD” un “Omniva” komunikācijas analīze sociālajos medijos “Facebook” un “Instagram” 2020. - 2021. gadā” mērķis ir noskaidrot un salīdzināt divus vienas sfēras uzņēmumu komunikāciju sociālo tīklu vietnēs “Facebook” un “Instagram” 2020. un 2021. gadā, kā arī uzzināt sociālo tīklu lietotāju domas par uzņēmumu komunikāciju sociālo tīklu vietnēs. Darbu veido teorētiskā bāze par zīmolu un mārketinga komunikāciju, sociālo tīklu vietnēm un medija lietojuma un apmierinājuma teoriju. Datu ieguvei izmantota kvantitatīvā kontentanalīze, aptauja un intervija. Rezultāti liecina, ka abi uzņēmumi publicē salīdzinoši līdzīgu saturu, bet katram uzņēmumam ir savas uzmanības pievērša…