Search results for "PEAK"
showing 10 items of 377 documents
Assessment of computational methods for the analysis of single-cell ATAC-seq data
2019
Abstract Background Recent innovations in single-cell Assay for Transposase Accessible Chromatin using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands of individual cells. scATAC-seq data analysis presents unique methodological challenges. scATAC-seq experiments sample DNA, which, due to low copy numbers (diploid in humans), lead to inherent data sparsity (1–10% of peaks detected per cell) compared to transcriptomic (scRNA-seq) data (10–45% of expressed genes detected per cell). Such challenges in data generation emphasize the need for informative features to assess cell heterogeneity at the chromatin level. Results We present a benchmarking framework that …
Smooth and non-smooth traveling wave solutions of some generalized Camassa–Holm equations
2014
In this paper we employ two recent analytical approaches to investigate the possible classes of traveling wave solutions of some members of a recently-derived integrable family of generalized Camassa-Holm (GCH) equations. A recent, novel application of phase-plane analysis is employed to analyze the singular traveling wave equations of three of the GCH NLPDEs, i.e. the possible non-smooth peakon, cuspon and compacton solutions. Two of the GCH equations do not support singular traveling waves. The third equation supports four-segmented, non-smooth $M$-wave solutions, while the fourth supports both solitary (peakon) and periodic (cuspon) cusp waves in different parameter regimes. Moreover, sm…
Unsteady State Water Level Analysis for Discharge Hydrograph Estimation in Rivers with Torrential Regime: The Case Study of the February 2016 Flood E…
2017
Discharge hydrograph estimation during floods, in rivers with torrential regime, is often based on the use of rating curves extrapolated from very low stage-discharge measurements. To get a more reliable estimation, a reverse flow routing problem is solved using water level data measured in two gauged stations several kilometers from each other. Validation of the previous analysis carried out on the flood event of February 2016 at the Europa Bridge and Castiglione Scalo sections of the Crati River (Cosenza, Italy) is based on the use of 'soft' discharge measurement data and the comparison of the water level data computed in the downstream gauged section by three different hydraulic models w…
Foreign language speaking anxiety: a case study in Secondary EFL students.
2021
En las últimas décadas, la ansiedad en una lengua extranjera (ALE) ha sido reconocida como una emoción en una situación específica que dificulta potencialmente el aprendizaje de un idioma. Este estudio ofrece un análisis completo de cómo la ansiedad afecta a la enseñanza de inglés como lengua extranjera (ELE) y a sus alumnos/as en Educación Secundaria. Los objetivos de esta investigación fueron, en primer lugar, examinar cómo reaccionan y se sienten los/las estudiantes al enfrentarse a situaciones de habla extranjera y, en segundo lugar, determinar cuáles de estas situaciones les provocan más o menos ansiedad. 28 alumnos/as de ELE de 3º y 4º de ESO participaron en una investigación mixta a …
Futures pricing in electricity markets based on stable CARMA spot models
2012
We present a new model for the electricity spot price dynamics, which is able to capture seasonality, low-frequency dynamics and the extreme spikes in the market. Instead of the usual purely deterministic trend we introduce a non-stationary independent increments process for the low-frequency dynamics, and model the large uctuations by a non-Gaussian stable CARMA process. The model allows for analytic futures prices, and we apply these to model and estimate the whole market consistently. Besides standard parameter estimation, an estimation procedure is suggested, where we t the non-stationary trend using futures data with long time until delivery, and a robust L 1 -lter to nd the states of …
Strengthening of steel-reinforced concrete structural elements by externally bonded FRP sheets and evaluation of their load carrying capacity to face…
2014
The paper has proposed a limit analysis procedure for a preliminary design of RC elements strengthened by externally bonded FRP sheets. The procedure, based on a multi-yield-criteria limit analysis approach, has led to a reliable prediction of peak loads and failure modes of the analyzed elements (slabs) by simultaneously considering the limit state of the constituent materials, so resulting very useful in many applications of engineering interest. The attention has been focused on hospital applications in which increment of service loads or realization of openings can weaken some structural elements that have been strengthened by FRP sheets.
The challenge for equity and excellence: Evidence for future successful action in bilingual Finland
2018
In 2013, the authors prepared a report on educational excellence and equity in Finland based on PISA 2009 data and asked the question “Could Finland achieve both excellence and equality goals in the coming decade? Five years later, this report re-examines the challenge faced by Finland in light of recent PISA results. The Finnish school system, both the Finnish and Swedish speaking components, have consistently ranked at the top of the list of OECD countries. However, Finland’s performance has been dropping compared to previous years, while it failed to keep pace with performance improvements in other countries. Simply working harder along the same path will no longer work. Therefore, this …
Glass Transition and Glass Dynamics
2014
The transition from an undercooled liquid towards a glass (glass transition) is introduced and discussed in terms of mode-coupling theory. It is demonstrated that mode-coupling theory leads to a two-step relaxation scenario near the transition with time-critical exponents, which characterize the two relaxation steps (beta and alpha relaxation). The anomalous vibrational properties of a disordered solid (glass) is explained in terms of a model with spatially fluctuating harmonic force constants.
Tehnisko kļūdu novērtēšana un izskaušana rinomanometrijā
2016
KOPASAVILKUMS Ievads: Jaunas metodes tiek ieviestas, lai rastu vienkāršākus un ātrākus risinājumus spiediena caurules fiksācijai rimomanometrijā. Svarīgi ir pētīt ietekmes uz gaisa plūsmu, lai izvairītos no kļudainiem mērījumiem. Ar datorprogrammu saistītā rinomanometrija pamazām tiek aizstāta ar PNIF ierīci, jo tā ir lētāka un vieglāka lietošanā, līdz ar to ir svarīgi vispirms novērot korelāciju starp abām metodēm. Mērķis: Diplomdarba mērķis bija apzināties un piefiksēt kļūdas un sarežģījumus, kādi rodas veicot četru fāzu rinomanometriju, izmantojot dažādas spiediena caurulītes piestiprināšanas metodes. Vēlviens uzdevums bija apzināties un piefiksēt kļūdas, kas rodas PNIF testa procesā, kā…
La perception phonémique en français des apprenants polonophones (le cas des voyelles antérieures de moyenne aperture : [e][ɛ])
2017
The perception of sounds of a foreign tongue influences the quality of comprehension and speaking in the language, as well as learning how to read and write properly. The differentiation and identification of sounds enables the development of aural-verbal memory, subsequently associating particular sound patterns with particular meanings. In other words, a developed perception of sounds ensures an efficient communication in a foreign language. Since learners perceive foreign sounds with varied proficiency, the teacher should recognize the difficulties and undertake remedial measures to facilitate learning progress. This article aims to present an educational tool, currently in development, …