Search results for "PEG"
showing 10 items of 460 documents
Tra Denuncia e Utopia. Impegno, critica e polemica nella letteratura tedesca. Studi in onore di Giuseppe Dolei.
2010
Extended duration of therapy with peginterferon alpha 2b and weight based ribavirin in HCV patients with genotype 3 infection
2009
PEG-INTERFERON PLUS RIBAVIRIN IN COMPENSATED HCV CIRRHOSIS WITH PORTAL HYPERTENSION: THE ROLE OF RAPID AND EARLY VIROLOGICAL RESPONSE IN PREDICTING T…
2009
Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis
2011
Background: Percutaneous endoscopic gastrostomy (PEG) is offered to amyotrophic lateral sclerosis (ALS) patients with severe dysphagia. Immediate benefits of PEG are adequate food intake and weight stabilization. However, the impact of PEG on survival is still uncertain. In this work we retrospectively evaluated the effect of PEG on survival in a cohort of ALS patients followed in a tertiary referral centre. Methods: Between 2000 and 2007, 150 dysphagic ALS patients were followed until death or tracheostomy. PEG was placed in 76 patients who accepted the procedure and survival was analysed using the Kaplan-Meier life-table method. Results: In ALS patients submitted to PEG, no major complica…
La Tavola e il Monte di Pietà di Palermo tra crisi e sperimentazione (1778-1799)
2011
Il sistema delle reti di credito che alimenta il mercato finanziario siciliano entra in stallo nella seconda metà del ‘700 quando si consuma la crisi istituzionale e gestionale non solo delle Tavole di Palermo e di Messina, ma anche dei Monti di Pietà. Un momento di transizione che può essere interpretato coniugando il concetto di “crisi” con quello di “sperimentazione”, poiché il “sistema” tenta di trovare soluzioni più efficienti per adeguare gli istituti esistenti alle nuove esigenze del mercato. Una “sperimentazione” che, ad esempio, spinge la Tavola di Palermo a istituire una sezione specializzata per sostenere i produttori di frumento grazie all’erogazione di crediti su pegno. Tentati…
Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1)…
2014
Although the addition of the HCV NS3/4A protease inhibitors boceprevir and telaprevir to pegylated interferon (peginterferon) alfa plus ribavirin has improved sustained virological response (SVR) in treatment-naive and treatment-experienced patients infected with hepatitis C virus (HCV) genotype 1, the regimens have a high pill burden and are associated with increased rates and severity of adverse events, such as anaemia and rash. The efficacy and safety of the combination of simeprevir, a one pill, once-daily, oral HCV NS3/4A protease inhibitor, plus peginterferon alfa 2a plus ribavirin were assessed in treatment-naive patients with HCV genotype 1 infection.In QUEST-1, a phase 3, randomise…
P0792 : Baseline factors associated with increased SVR rates in 123 treatment-naïve chronic HCV genotype 1 patients treated with a shortened 12-week …
2015
Implementation of JPEG2000 arithmetic decoder using dynamic reconfiguration of FPGA
2005
This paper describes implementation of a part of JPEG2000 algorithm (MQ-Decoder and arithmetic decoder) on a FPGA board using dynamic reconfiguration. Comparison between static and dynamic reconfiguration is presented and new analysis criteria (time performance, logic cost, spatio-temporal efficiency) are defined. MQ-decoder and arithmetic decoder can be classified in the most attractive case for dynamic reconfiguration implementation: applications without parallelism by functions. This implementation is done on an architecture designed to study dynamic reconfiguration of FPGAs: the ARDOISE architecture. The implementation obtained, based on four partial configurations of arithmetic decoder…
Crystallization and preliminary X-ray analysis of native and selenomethionyl vinorine synthase from Rauvolfia serpentina.
2005
Vinorine synthase (VS) is a central enzyme of the biosynthesis of the antiarrhythmic drug ajmaline and is a member of the BAHD superfamily of acyltransferases. So far, no three-dimensional structure with significant sequence homology with VS is known. Crystals of VS and selenomethionyl-labelled VS from the medicinal plant Rauvolfia serpentina have been obtained by the hanging-drop technique at 305 K with ammonium sulfate and PEG 400 as precipitants. VS crystals diffract to 2.8 Å and belong to space group P212121, with unit-cell parameters a = 82.3, b = 89.6, c = 136.2 Å. The selenomethionyl VS crystal was nearly isomorphous with the VS crystal.
Comparison of linear and hyperbranched polyether lipids for liposome shielding by 18F-radiolabeling and positron emission tomography
2018
Multifunctional and highly biocompatible polyether structures play a key role in shielding liposomes from degradation in the bloodstream, providing also multiple functional groups for further attachment of targeting moieties. In this work hyperbranched polyglycerol (hbPG) bearing lipids with long alkyl chain anchor are evaluated with respect to steric stabilization of liposomes. The branched polyether lipids possess a hydrophobic bis(hexadecyl)glycerol membrane anchor for the liposomal membrane. hbPG was chosen as a multifunctional alternative to PEG, enabling the eventual linkage of multiple targeting vectors. Different hbPG lipids (Mn = 2900 and 5200 g mol-1) were examined. A linear bis(h…