Search results for "PES"
showing 10 items of 5212 documents
Ubertino da Corleone
2020
Originario di Corleone, Ubertino era un francescano minore con una solida preparazione, abituato a interloquire con papi e re. La sua abilità oratoria fu apprezzata da Giovanni Boccaccio, che l’incontrò a Napoli. Studiò teologia a Londra, Oxford, Parigi, fu lettore a Pisa e Padova. Tornato in Sicilia, divenne cappellano regio e nel 1372 partecipò ai negoziati di pace tra Federico IV, re di Sicilia, e Giovanna I, regina di Napoli. Ad Avignone, incontrò Gregorio XI, che lo nominò vescovo di Corico, nel Regno di Cilicia. Fu poi vescovo di Patti e Lipari e nel 1396 si recò in Aragona per mediatore tra il papa romano Bonifacio IX e il papa avignonese Benedetto XIII. In seguito, divenne vescovo d…
Intrapulmonary 3He Gas Distribution Depending on Bolus Size and Temporal Bolus Placement
2008
OBJECTIVE: Dynamic ventilation (3)He-MRI is a new method to assess pulmonary gas inflow. As differing airway diameters throughout the ventilatory cycle can influence gas inflow this study intends to investigate the influence of volume and timing of a He gas bolus with respect to the beginning of the tidal volume on inspiratory gas distribution. MATERIALS AND METHODS: An ultrafast 2-dimensional spoiled gradient echo sequence (temporal resolution 100 milliseconds) was used for dynamic ventilation (3)He-MRI of 11 anesthetized and mechanically ventilated pigs. The applied (3)He gas bolus was varied in volume between 100 and 200 mL. A 150-mL bolus was varied in its application time after the beg…
Transporter (TAP)- and proteasome-independent presentation of a melanoma-associated tyrosinase epitope.
2000
The melanosomal protein tyrosinase is considered as a target of specific immunotherapy against melanoma. Two tyrosinase-derived peptides are presented in association with HLA-A2.1 [Wolfel et al., Eur. J. Immunol., 24, 759-764 (1994)]. Peptide 1-9 (MLLAVLYCL) is generated from the putative signal sequence. The internal peptide 369-377 is posttranslationally converted at residue 371, and its presentation is dependent on functional TAP transporters and proteasomes [Mosse et al., J. exp. Med.187, 37-48 (1998)]. Herein, we report on the processing and transport requirements for the signal sequence-derived peptide 1-9 that were studied in parallel to those for peptide 369-377. After infection of …
Properties of modified hepatitis B virus surface antigen particles carrying preS epitopes
1995
The current hepatitis B virus (HBV) vaccines contain the small (S) and middle (M) viral envelope proteins in particulate form but lack the large (L) protein. Although these particles elicit protective immunity to HBV, inclusion of the immunogenic preS1 region of the L protein may enhance their efficacy. To present preS1-derived epitopes on secretable subviral particles we rearranged the HBV envelope ORF by fusing part or all of the preS1 region to either the N or C terminus of the S protein. Fusion of the first 42 residues of preS1 to either site allowed efficient secretion of the modified particles and rendered the linked sequence accessible at the surface of the particle. Conversely, fusi…
Flip angle considerations in (3)helium-MRI.
2000
3Helium-MRI ((3)He-MRI) can be used for analysis of lung function, e. g. dynamic imaging of ventilation and gas diffusion within the lung, assessment of intrapulmonary oxygen concentrations and their time course. During imaging, the irreversible signal loss due to depolarizing radio frequency excitations can be described using the flip angle (FA) alpha. This parameter has to be quantified in order to account for it during quantitative assessment of the (3)helium signal intensity and its temporal development. This technical report reviews two different methods to determine alpha. Limitations and possible error sources of each method are discussed.
Une carte et une base de données pour les formations à silex dans le Sud de la France.
2012
Programme et résumés, page 139; Une carte est en cours de réalisation pour figurer les principales formations contenant des silex dans le Sud de la France. Elle est le fruit d'une collaboration entre des acteurs impliqués dans la problématique de caractérisation de la provenance des silex. Elle regroupe les résultats de leurs prospections systématiques ou ciblées dans cinq régions (Auvergne, Rhône-Alpes, Provence Alpes Côte-d'Azur, Aquitaine, Midi-Pyrénées). Elle intègre le dépouillement d'un nombre considérable de documents : - 529 cartes géologiques au 1/50 000 et leurs notices ; - Plus de 200 fiches issues de la base de données du sous-sol BSS du BRGM, qui permettent de visualiser des lo…
Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluat…
2017
Background: Few data are available on the virological and clinical outcomes of advanced liver disease patients retreated after first-line DAA failure. Aim: To evaluate DAA failure incidence and the retreatment clinical impact in patients treated in the advanced liver disease stage. Methods: Data on HCV genotype, liver disease severity, and first and second line DAA regimens were prospectively collected in consecutive patients who reached the 12-week post-treatment and retreatment evaluations from January 2015 to December 2016 in 23 of the PITER network centers. Results: Among 3,830 patients with advanced fibrosis (F3) or cirrhosis, 139 (3.6%) failed to achieve SVR. Genotype 3, bilirubin lev…
Solution-mass-transfer deformation adjacent to the Glarus Thrust, with implications for the tectonic evolution of the Alpine wedge in eastern Switzer…
2001
Abstract We have studied aspects of absolute finite strain of sandstones and the deformation history above and below the Glarus Thrust in eastern Switzerland. The dominant deformation mechanism is solution mass transfer (SMT), which resulted in the formation of a semi-penetrative cleavage. Our analysis indicates that the Verrucano and Melser sandstones, which lie above the thrust, were deformed coaxially, with pronounced contraction in a subvertical Z direction and minor extension in a subhorizontal X direction, trending at ∼200°. Most of the contraction in Z was balanced by mass-loss volume strains, averaging ∼36%. Below the Glarus Thrust, sandstones of the North Helvetic flysch have small…
Ribonuclease H levels in herpes simplex virus-infected cells.
1980
Two forms of ribonuclease H (RNase H) have been identified both in uninfected and Herpes Simplex virus (HSV-)infected BHK cells. Identical RNase H species were detected in control- as well as in infected cells. RNase H I and II have not been found to be associated both with host cell DNA polymerase alpha and beta and HSV-induced DNA polymerase. Infection of BHK cells with HSV type 1 does not lead to a pronounced alteration of RNase H II activity but to an increase (3-fold) of the extractable RNase H I activity. RNase H I activity increases to a maximum between 8-10 hours p.i.; the bulk of HSV-DNA synthesis occurs between 6-8 hours p.i. From these experiments we draw the preliminary conclusi…
The region 0.7615-0.796 m.u. of the HSV-1 genome determines suppression of humoral antibody formation against herpes simplex virus.
1991
The influence of genetic properties of parts of the HSV-1 genome on suppression of humoral antibody formation was investigated by using intratypic recombinants. The deleted strain HFEM (HSV-1) induces suppression. The MluI DNA fragment (coordinates 0.7615–0.796 m.u.) derived from the antibody inducing strain F1 (HSV-1) was transfected into the deleted strain HFEM to produce the recombinant virus R-MlCI and shown to restore antibody formation, as demonstrated by neutralization- and ELISA-tests. The intratypic recombinant viruses R-15, R-19 and R-26, produced by transfection of the Bam HI DNA-fragment B (0.738–0.809 m.u.) of strain Fl into the deleted strain HFEM, resulted in antibody formati…