Search results for "PID"

Single-cell analysis of population context advances RNAi screening at multiple levels

2012

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…

Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering an…

2021

To efficiently lower virus infectivity and combat virus epidemics or pandemics, it is important to discover broadly acting antivirals. Here, we investigated two naturally occurring polyphenols, Epigallocatechin gallate (EGCG) and Resveratrol (RES), and polyphenol-functionalized nanoparticles for their antiviral efficacy. Concentrations in the low micromolar range permanently inhibited the infectivity of high doses of enteroviruses (107 PFU/mL). Sucrose gradient separation of radiolabeled viruses, dynamic light scattering, transmission electron microscopic imaging and an in-house developed real-time fluorescence assay revealed that polyphenols prevented infection mainly through clustering of…

Presencia y análisis genético de una tortuga bastarda (Lepidochelys kempii) en el mar Mediterráneo

2003

We report on a juvenile Kemp´s ridley sea turtle, Lepidochelys kempii, captured alive by fishermen in the waters off Alicante (western Mediterranean, Spain) on October 15th 2001. The analysis of a 460 base pair fragment of the mt DNA control region revealed a perfect match with haplotype D previously described in this species. This is the second report of L. kempii in the Mediterranean basin.

Los criterios de selección de los trabajadores afectados por el despido colectivo

2019

La Tesi aborda la recerca relativa als criteris de selecció dels treballadors afectats en el marc de l’acomiadament col·lectiu en el Dret espanyol. Per això, es delimita teòricament el marc d’estudi –el dels criteris de selecció–, amb referència a la seua immediata contextualització normativa, que no és altra que la relativa a la regulació dels acomiadaments col·lectius en l’ordenament espanyol, tot i que, això sí, destacant-ne les implicacions del Dret de la Unió Europea. Quant a l’acomiadament col·lectiu, la recerca se situa en els efectes produïts per la important reforma laboral duta a terme l’any 2012, així com en el sempre difícil equilibri entre els legítims interessos empresarials i…

Traduire le terme oppidum : un exemple des difficultés posées par le Bellum ciuile de César

2020

Our purpose here is not to analyze again in detail the term oppidum and its definition, but rather to see how it was used in the specific context of Caesar’s Bellum ciuile. Previous analyses focused mainly on its use in the De Bello Gallico. Thus, the context in which the author uses the term oppidum in a work completed after the Gallic War leads, on the one hand, to question Caesar’s choice of the word oppidum, and, on the other hand, to propose different translations for it; it is through several examples that I wish to underline the complexity of the translator’s approach.

Théories, méthodologies et outils en vue de la mise en place d'une plateforme d’ingénierie sociale et de recherche-action en Sciences humaines & soci…

2012

"Figure 9c-2" of "Deviation from quark-number scaling of the anisotropy parameter v_2 of pions, kaons, and protons in Au+Au collisions at sqrt(s_NN) …

2023

The quark-number-scaled $v_2$ ($v_2/n_q$) of identified hadrons are shown as a function of the kinetic energy per quark, KE$_T/n_q$ in 0–10% centrality [panel (a)] in Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV. The error bars (shaded boxes) represent the statistical (systematic) uncertainties. The systematic uncertainties shown are type A and B only.

"Figure 8b-2" of "Deviation from quark-number scaling of the anisotropy parameter v_2 of pions, kaons, and protons in Au+Au collisions at sqrt(s_NN) …

2023

Identified hadron $v_2$ in central (0–20% centrality, left panels) Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV. Panels (a) and (b) show $v_2$ as a function of transverse momentum $p_T$. The $v_2$ of all species for centrality 0–20% has been scaled up by a factor of 1.6 for better comparison with results of 20–60% centrality. The error bars (shaded boxes) represent the statistical (systematic) uncertainties. The systematic uncertainties shown are type A and B only.

"Figure 10b-2" of "Deviation from quark-number scaling of the anisotropy parameter v_2 of pions, kaons, and protons in Au+Au collisions at sqrt(s_NN)…

2023

The quark-number-scaled $v_2$ ($v_2/n_q$) of identified hadrons are shown as a function of the kinetic energy per quark, KE$_T/n_q$ in 10–40% centrality [panel (b)] in Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV. The $v_2$ of $\Lambda$ and K$^0_S$ are measured by STAR collaboration [21]. The error bars (open boxes) represent the statistical (systematic) uncertainties. The systematic uncertainties shown on the results from this study are type A and B only.

"Figure 10b-1" of "Deviation from quark-number scaling of the anisotropy parameter v_2 of pions, kaons, and protons in Au+Au collisions at sqrt(s_NN)…

2023

The quark-number-scaled $v_2$ ($v_2/n_q$) of identified hadrons are shown as a function of the kinetic energy per quark, KE$_T/n_q$ in 10–40% centrality [panel (b)] in Au + Au collisions at $\sqrt{s_{NN}}$ = 200 GeV. The $v_2$ of $\Lambda$ and K$^0_S$ are measured by STAR collaboration [21]. The error bars (open boxes) represent the statistical (systematic) uncertainties. The systematic uncertainties shown on the results from this study are type A and B only.