Search results for "PIDE"

ETC-1002: A future option for lipid disorders?

2014

ETC-1002 is a new investigational low density lipoprotein cholesterol (LDL-C)-lowering agent (Esperion Therapeutics, Inc.). ETC-1002 is a dicarboxylic acid derivative with a novel mechanism of action targeting two hepatic enzymes - adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK), inhibiting sterol and fatty acid synthesis and promoting mitochondrial long-chain fatty acid oxidation. This agent is currently in phase II clinical research. Available data report that ETC-1002 significantly decreased LDL-C levels (up to 32%) in both patients with normal and elevated baseline levels of triglycerides. Such beneficial effect is superior to curre…

Antisense lipoprotein[a] therapy: State-of-the-art and future perspectives

2020

Several lines of evidence now attest that lipoprotein[a] (Lp[a]) is a significant risk factor for many cardiovascular disorders. This enigmatic lipoprotein, composed of a single copy of apolipoprotein B (apoB) and apolipoprotein[a] (apo [a]), expresses peculiar metabolism, virtually independent from lifestyle interventions. Several therapeutic options have hence been proposed for lowering elevated Lp[a] values, with or without concomitant effect on low density lipoprotein (LDL) particles, mostly encompassing statins, ezetimibe, nicotinic acid, lipoprotein apheresis, and anti-PCSK9 monoclonal antibodies. Since all these medical treatments have some technical and clinical drawbacks, a novel s…

Relationship Between the Apolipoprotein E Genotype and LDL Particle Size in Patients With Obstructive Sleep Apnea.

2016

Obstructive sleep apnea (OSA) is associated with dyslipidemia and increased cardiovascular risk. We assessed the effects of apolipoprotein E ( APOE) genotype on low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particle size and lipid subclasses (separated by gradient gel electrophoresis) in patients with OSA. Stable patients (n = 181) prospectively recruited underwent full polysomnography. Both LDL particle size and LDL I proportion were reduced from ∊3∊3 homozygotes to ∊2 carriers and to ∊4 carriers (analysis of variance: P = .024; P = .040, respectively); carriers of the ∊4 allele of the APOE genotype had significantly lower LDL particle size and LDL I proportion compared…

Serum lipid responses to phytosterol-enriched milk in a moderate hypercholesterolemic population is not affected by apolipoprotein E polymorphism or …

2011

Background/Objectives: The importance of both low-density lipoprotein cholesterol (LDLc) size and the apolipoprotein E (Apo E) in the atherogenic process is known, but there is little information with regard to the effect of phytosterols (PS) on these parameters. The aim of this study was to evaluate the influence of PS on lipid profile and LDLc size according to Apo E genotype. Subjects/Methods: This was a randomized parallel trial employing 75 mild-hypercholesterolemic subjects and consisting of two 3-month intervention phases. After 3 months of receiving a standard healthy diet, subjects were divided into two intervention groups: a diet group (n = 34) and a diet+PS group (n = 41) that re…

Israeli spotted fever Rickettsia in Sicilian Rhipicephalus sanguineus ticks [6]

2003

Arachnid oenocytes: ecdysone synthesis in the legs of harvestmen (Opilionidae).

1981

Cells measuring up to 130 microns have been found in the proximal segments of the femora of all four pairs of walking legs in various species of harvestmen (Phalangium opilio, Leiobonum limbatum, Opilio parietinus, and Opilio ravennae). These cells exhibit all the fine-structural characteristics of insect oenocytes, in particular the conspicuous agranular endoplasmic reticulum. Radioimmunoassay after in vitro incubation of these cells has demonstrated the synthesis of alpha- and beta-ecdysone. These ecdysteroids have been found in the ovaries and tergites of the opisthosoma as well as in the oenocytes.

Complete Hemocyanin Subunit Sequences of the Hunting SpiderCupiennius salei

2002

Hemocyanins are large copper-containing respiratory proteins found in many arthropod species. Scorpions and orthognath spiders possess a highly conserved 4 x 6-mer hemocyanin that consists of at least seven distinct subunit types (termed a to g). However, many "modern" entelegyne spiders such as Cupiennius salei differ from the standard arachnid scheme and have 2 x 6-mer hemocyanins. Here we report the complete primary structure of the 2 x 6-mer hemocyanin of C. salei as deduced from cDNA sequencing, gel electrophoresis, and matrix-assisted laser desorption spectroscopy. Six distinct subunit types (1 through 6) and three additional allelic sequences were identified. Each 1 x 6-mer half-mole…

BIOMECHANICAL FACTORS TO BE TAKEN INTO ACCOUNT TO PREVENT INJURIES AND IMPROVE SPORTING PERFORMANCE ON ARTIFICIAL TURF

2009

This article reviews existing knowledge concerning the epidemiology, instruments and regulatory criteria currently used to evaluate artificial turf soccer pitches. Recent years have seen tremendous growth in the use of artificial turf as a playing surface for sports (rugby, soccer, American football…) and the problems traditionally associated with artificial turf and its relationship with a higher percentage of injuries seem to be disappearing. The contribution of biomechanics to the development of new techniques and instruments for analysing the properties and characteristics of grass pitches has contributed towards close collaboration with the regulatory bodies of different sporting organ…

Eurípides, Helena 435-482. Elementos conversacionales, humor y guiños aristofánicos en una tragedia

2010

En este artículo el autor trata de estudiar en detalle los elementos conversacionales de un conocido pasaje de la Helena de Eurípides, su connatural asiento en la dicción de la tragedia, su interacción con algunos elementos humorísticos, los problemas que esto plantea y la ponderación de todo ello con una visión ecléctica. Se llega a la conclusión de que Eurípides introduce humor y guiños a la Comedia aristofánica en este caso y que, gracias a su talento dramático, no desvirtúa la esencia de la tragedia. This paper deals with a detailed study of conversational idioms in a well-known scene of Euripides’ Helen, their connatural place in the diction of tragedy, their interaction with some humo…

On the geographical distribution of pseudocholinesterase variants.

1975

The incidence of pseudocholinesterase (PCHE equals E.C. 3.1.1.8) variants in samples of 8 different population (total of 2218 individuals) is reported. Together with previously mentioned data from the literature, a general survey on the geographical distribution of PCHE isoenzymes is given. Possible reasons for present-day heterogeneity of their distribution are also discussed. Concerning the incidence of the C5 variant, it is pointed out that the validity of applying population genetic models depends upon the accuracy of the genetic basis.