Search results for "PIDE"

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

2009

We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).

Maturation of Epidermal Langerhans Cells In Vitro Is Accompanied by Downregulation of 4F2 (CD98) as Determined by Differential Display

1998

Following short-term culture, Langerhans cells mature morphologically and functionally into potent immunostimulatory cells. As regulation of gene expression accompanies this maturation process, it is likely that differentially expressed genes are involved in the maturation events. Using the recently described method of differential display, we generated cDNA expression patterns starting with mRNA of murine epidermal Langerhans cells isolated either directly (fLC) or following 3 d cultivation (cLC). Five hundred putative differentially expressed cDNA fragments were recovered from the gel. For a part of the fragments differential expression was confirmed by dot blot and Southern hybridization…

Slavinājuma konstruējums Plīnija Jaunākā darbā “Panegyricus ad Traianum”

2016

Grīnberga J. Slavinājums konstruējums Plīnija Jaunākā darbā: „Panegyricus ad Traianum”: bakalaura darbs. Rīga: LU, 2016. 52 lpp., 59.bibl. nos. Šī darba mērķis ir izpētīt, kā tiek īstenots slavinājuma konstruējums Plīnija Jaunākā Panegīrikā. Darba uzdevumi: apzinot tulkojumus un oriģināltekstu, izanalizēt un novērtēt kompozicionālo un leksisko materiālu, kas darbā tiek plaši izmantots dažādās kategorijās. Iegūstot priekšstatu par slavinājuma nozīmi, uzbūvi un izpratni retorikas teorijas kontekstā. Teorētiskajā daļā apskatīta retorikas teorija epideiktiskās runas kontekstā un leksiski semantiskā lauka teorija, bet praktiskā daļa balstīta slavinājuma runas analīzē. Apkopojot rezultātus, ir se…

Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL.

2022

Atherosclerosis is responsible for large cardiovascular mortality in many countries globally. It has been shown over the last decades that the reduction of atherosclerotic progression is a critical factor for preventing future cardiovascular events. Low-density lipoproteins (LDL) have been successfully targeted, and their reduction is one of the key preventing measures in patients with atherosclerotic disease. LDL particles are pivotal for the formation and progression of atherosclerotic plaques; yet, they are quite heterogeneous, and smaller, denser LDL species are the most atherogenic. These particles have greater arterial entry and retention, higher susceptibility to oxidation, as well a…

Refining the preconditions of a social licence to operate (SLO) : reflections on citizens’ attitudes towards mining in two Finnish regions

2016

The debate around the social licence to operate (SLO) has been lively in recent years. In its elementary forms, the SLO is interpreted as the social acceptance granted by a community to mineral exploration and mining activities. Our theoretical assumption is that the SLO as a concept is both case-specific and more general, contingent, among other things, upon public opinion. In this study, acceptance is considered as general and anticipatory in the sense that it can act as a precondition for individual SLOs. Our intention is to contribute especially to recent novel research focusing on the more general background and factors contributing to the SLO. Using survey data (N = 1064), we explore …

bbFISH-ing in the sonication fluid

2019

Abstract By 2030, the annual number of combined total hip and knee arthroplasty is estimated to reach 3.5 to 4 million in the US alone. In the context of a constant increase of the number of primary and revision total hip and knee arthroplasty, an increased risk of complication is expected. Prosthetic joint infections (PJIs) represent major cause of healthcare expenditure and morbidity. PJI still remain the most common and feared arthroplasty complication. A rapid and correct diagnosis of infection is decisive for a correct therapeutical management. In this setting, the Academic Emergency Hospital Sibiu adopted and implemented, with the beginning of September 2016, a new strategy for the di…

Discovery of a new class of sortase a transpeptidase inhibitors to tackle gram-positive pathogens: 2-(2-phenylhydrazinylidene)alkanoic acids and rela…

2016

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and acid derivatives. The most active derivative found was 3-oxo-2-(2-(3,4dichlorophenyl)hydrazinylidene)butanoic acid (2b), showing an IC50 value of 50 µM. For a preliminary assessment of their antivirulence properties the new derivatives were tested for their antibiofilm activity. The most active compo…

Perustulokeskustelu Suomessa : sisällönanalyysi perustulokeskustelusta Helsingin Sanomien mielipidekirjoituksissa 1990-2015

2016

TIIVISTELMÄ JYVÄSKYLÄN YLIOPISTO Yhteiskuntatieteellinen tiedekunta, sosiaalityön yksikkö MANNINEN, TEEMU: Perustulokeskustelu Suomessa – Sisällönanalyysi perustulokeskustelusta Helsingin Sanomien mielipidekirjoituksissa 1990-2015 Pro gradu –tutkielma, 86 s. Ohjaaja: Kati Närhi Elokuu 2016 Tutkimuksessa selvitetään Helsingin Sanomien mielipidekirjoitusten perusteella millaisena Suomessa käyty perustulokeskustelu on näyttäytynyt vuosien 1990-2015 välisenä aikana. Perustulolla tarkoitetaan kuukausittain kansalaisille vastikkeettomasti maksettavaa rahasummaa, jonka saamiseksi ei edellytetä työvelvoitetta eikä sen saaminen ole sidonnainen varallisuuteen, ansioihin, asuinpaikkaan tai siviilisäät…

Silk-Water: a dynamic duo

2010

Testing the effectiveness of pyrazine defences against spiders

2020

Insects live in a dangerous world and may fall prey to a wide variety of predators, encompassing multiple taxa. As a result, selection may favour defences that are effective against multiple predator types, or target-specific defences that can reduce predation risk from particular groups of predators. Given the variation in sensory systems and hunting tactics, in particular between vertebrate and invertebrate predators, it is not always clear whether defences, such as chemical defences, that are effective against one group will be so against another. Despite this, the majority of research to date has focused on the role of a single predator species when considering the evolution of defended…