Search results for "PIO"

Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain inj…

2013

Following traumatic brain injury (TBI) neuroinflammatory processes promote neuronal cell loss. Alpha-melanocyte-stimulating hormone (α-MSH) is a neuropeptide with immunomodulatory properties, which may offer neuroprotection. Due to short half-life and pigmentary side-effects of α-MSH, the C-terminal tripeptide α-MSH(11-13) may be an anti-inflammatory alternative. The present study investigated the mRNA concentrations of the precursor hormone proopiomelanocortin (POMC) and of melanocortin receptors 1 and 4 (MC1R/MC4R) in naive mice and 15 min, 6, 12, 24, and 48 h after controlled cortical impact (CCI). Regulation of POMC and MC4R expression did not change after trauma, while MC1R levels incr…

Synthesis and anti-inflammatory activity of chalcone derivatives

1998

Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4-7) inhibited cyclo-oxygenase-2 activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model.

La dynamique socio-spatiale de l'Elite Athlétique: entre déterminisme démographique et stratégie politique: le cas de l'Elite Athlétique Française (1…

2005

International audience

Championnière Paul-Lucas

2007

Entrée de dictionnaire; Dictionnaire historique des juristes français XIIe-XXe siècles

Effects of overabundant nitrate and warmer temperatures on charophytes: The roles of plasticity and local adaptation

2018

Global change effects, such as warming and increases in nitrogen loading, alter vulnerable Mediterranean aquatic systems, and charophytes can be one of the most affected groups. We addressed the possible interaction between these factors on two populations of the cosmopolitan charophytes Chara hispida and Chara vulgaris. Populations were taken from two different environments, a nitrate-poor mountain lake and a nitrate-rich Mediterranean coastal spring. The laboratory experiment had a 2 × 2 factorial design based on two nitrate levels (similar to and double the local conditions) and two temperatures. Increased temperatures favoured the growth of the four populations, but an increase in nitra…

Porous materials as delivery and protective agents for Vitamin A

2016

The suitability of porous materials to immobilize and release under control bioactive molecules prompted us to design and study delivery systems of Vitamin A (VitA). This molecule, relevant in several physiological functions, is easily oxidized. Commercial VitA was immobilized in two different clays, montmorillonite K-10 (MMT) and sepiolite (SEP), and in MCM-41, by impregnation. Characterization of the resulting hybrid materials by XRD, FTIR and 13C and 29Si (MAS) NMR spectroscopies revealed its presence. The photo-stability tests showed decreased degradation of VitA in the clays, compared to MCM-41 and the pure VitA, while thermostability is observed until ∼100 °C. The kinetics of the rele…

ChemInform Abstract: Microwave-Assisted Organocatalytic Enantioselective Intramolecular Aza-Michael Reaction with α,β-Unsaturated Ketones.

2012

The combination of an epi-hydroquinine catalyst and pentafluoropropionic acid accelerates the process.

Editorial: Advanced Functional Materials Derived From One-Dimensional Clay Minerals

2021

The principles of bioethics and the growth of an intercultural bioethics

2010

En este trabajo defiendo que el debate internacional sobre los principios de la bioética es uno de los más fructíferos para construir los fundamentos de una bioética intercultural. Tras recordar en qué consisten los principios de la bioética, tal y como han sido defendidos por Tom L. Beauchamp y James F. Childress en Estados Unidos, ofrezco una breve mirada a estos principios desde Europa, América Latina, África y Asia. Continúo con una reflexión sobre dichos principios desde algunas de las grandes religiones del mundo. Todo ello me permite ofrecer importantes elementos para construir las bases de lo que podríamos llamar una «bioética intercultural». In this article, I defend that the inter…

Chiral Symmetry And Low Energy Pion Photoproduction

1992

The low energy theorem based on chiral symmetry for the photoproduction of neutral pions from proton at threshold is reviewed in the light of recent experimental results from Saclay and Mainz. There is no appreciable disagreement at threshold but the energy dependence of the threshold amplitude remains unexplained. A critique of the assumptions made in deriving low energy theorems by various methods is presented.