Search results for "PIP"
showing 10 items of 1156 documents
Synthesis and Influence of 3-Amino Benzoxaboroles Structure on Their Activity against Candida albicans
2020
Benzoxaboroles emerged recently as molecules of high medicinal potential with Kerydin®
Mechanochemical synthesis of antifungal bis(benzoxaboroles)
2020
Several piperazine bis(benzoxaboroles) have been obtained both in solution as well as in the solid state. The environmentally friendly mechanochemical approach – hitherto not applied for the preparation of benzoxaboroles – was particularly beneficial in the case of two products afforded in low yields in solution. The in vitro studies showed high potential of the studied bis(fluorobenzoxaboroles) as antifungal agents, highlighting also the influence of the fluorine substituent position on their microbiological activity. The highest activity against A. niger, A. terreus, P. ochrochloron, C. tenuis and C. albicans was displayed by the analogue of the known benzoxaborole antifungal drug Kerydin…
Synthesis and structural elucidation of novel antifungal N-(fluorophenyl)piperazinyl benzoxaboroles and their analogues
2019
Abstract Series of novel N-(fluorophenyl)piperazine derivatives of phenylboronic compounds including benzoxaboroles, phenylboronic acids and phenylboronic methyl monoester have been obtained by facile synthetic methods starting from 2-formylphenylboronic acid. Molecular and crystal structures of those novel derivatives have been investigated by single crystal X-ray diffraction method. The Bond Valence Vector Model was used to describe strains in the boron coordination sphere. Microbiological activity of novel benzoxaboroles as well as their corresponding acid analogues against: A. niger, A. terreus, P. ochrochloron, C. tenuis and F. dimerum has been evaluated. The presence of heterocyclic b…
Constituents of Peperomia vulcanica Baker & C. H. Wright (Piperaceae) with antiparasitic activity
2021
Abstract The investigation of the CH2Cl2-MeOH (1:1) extract of Peperomia vulcanica which showed antileishmanial activity during preliminary screening led to the isolation of two previously unknown compounds named peperolignan (1) and peperotannin (2) along with 13 known compounds. Their structures were determined on the basis of their spectroscopic data. The isolated compounds were assessed in vitro for their antileishmanial and antiplasmodial activities against Leishmania donovani 1S (MHOM/SD/62/1S) promastigotes and the Plasmodium falciparum chloroquine-sensitive 3D7 strain (Pf3D7), respectively. They were also assessed for their cytotoxicity on Raw 264.7 macrophage cells. The mixture of …
Distribution patterns of epiphytic reed-associated macroinvertebrate communities across European shallow lakes
2021
So far, research on plant-associated macroinvertebrates, even if conducted on a large number of water bodies, has mostly focused on a relatively small area, permitting limited conclusions to be drawn regarding potentially broader geographic effects, including climate. Some recent studies have shown that the composition of epiphytic communities may differ considerably among climatic zones. To assess this phenomenon, we studied macroinvertebrates associated with the common reed Phragmites australis (Cav.) Trin. ex Steud in 46 shallow lakes using a common protocol. The lakes, located in nine countries, covered almost the entire European latitudinal range (from <48°N to 61°N) and captured much …
CO2 capture from biogas: Absorbent selection
2013
The development of proper biogas upgrading technology offers a viable means to utilize biogas in conventional power systems. In this paper, various molecular and ionic solvent systems were evaluated for CO2 removal from biogas in a loop reactor system. The performance of amine solutions, ionic liquids and their mixtures, amino acid salts and solutions blended with piperazine was compared in terms of their CO2 loading capacity. The experimental results revealed that addition of small amounts of piperazine can increase on average by 30 vol% the efficiency of above-mentioned solutions. The CO2 capturing capacity achieved for the most promising solvents was in the range of 50–60 L CO2/L absorbe…
Photocatalytic green synthesis of piperonal in aqueous TiO2 suspension
2014
Abstract Piperonal (heliotropine or 3,4-methylenedioxybenzaldehyde) has been synthesized by oxidizing piperonyl alcohol in aqueous UV-irradiated TiO2 suspensions. This compound was identified by GC–MS chromatography, 1H NMR and melting point determination. The other products of the photoprocess were 1,3-bis(3,4-(methylenedioxy)benzyl) ether (found in traces) and CO2, derived from the parallel pathway of photo-mineralization. Commercial and home-prepared TiO2 samples have been tested and the best selectivity (ca. 35%) was obtained by using the home-prepared ones. The reported green process allows to obtain an added value product (piperonal), upon partial oxidation of a cheap reagent.
The Mediterranean Sea and the Gulf of Cadiz as a natural laboratory for paleotsunami research: Recent advancements
2021
International audience; After the 2004 Indian Ocean (IOT) and the 2011 Tohoku-oki tsunamis, new research in tsunami-related fields was strongly stimulated worldwide and also in the Mediterranean. This research growth yields substantial advancements in tsunami knowledge.Among these advancements is the “Paleotsunami” research that has marked particular progress on the reconstruction of the tsunami history of a region. As an integration of the historical documentation available in the Mediterranean and the Gulf of Cadiz areas, geological and geoarchaeological records provide the insights to define the occurrence, characteristics, and impact of tsunamis of the past. Here, we present the recent …
Osteological evidence for the Battles of Zürich, 1799: a glimpse into soldiery of the past
2003
Institute of Anthropology, University of Mainz, GermanyABSTRACT Four human skeletons probably could be attributed to people killed during the Battles ofZu¨rich in 1799. Cranial and postcranial gunshot wounds are consistent with those made byblack powder weapons using lead balls as ammunition. Additional finds include a probablecase of Scheuermann’s Disease and a pipe smoker’s facet. Copyright 2003 John Wiley S Switzerland; gunshot wounds; Scheuermann’s disease; pipesmoking; palaeopathology
Antiguas excavaciones, nuevas respuestas. El yacimiento epimagdaleniense de la Cova del Clot de l'Hospital (Roquetes, Baix Ebre)
2015
El objetivo de este trabajo ha sido estudiar los materiales obtenidos con las excavaciones de Francesc Esteve Gálvez en la Cova del Clot de l’Hospital (Bajo Ebro), yacimiento de finales del Pleistoceno-inicios del Holoceno, descubierto por él mismo el año 1945. La representación de raspadores, truncaduras, buriles y laminitas de dorso, entre otros tipos, permite atribuirlo al Epimagdaleniense, atribución corroborada por dos fechas radiocarbónicas sobre huesos de fauna: 11.115 y 10.045 BP. De esta forma, este yacimiento se suma a un numeroso conjunto de yacimientos del período citado, conocidos en las provincias de Tarragona y de Castellón de la Plana. Así mismo, el estudio de los restos fau…