Search results for "PIP"
showing 10 items of 1156 documents
Response of benthic foraminifera to heavy metal contamination in marine sediments (Sicilian coasts, Mediterranean sea)
2011
To examine the suitability of benthic foraminifera and their test deformations as bioindicators of pollution in coastal marine environments, we studied foraminifera and metal concentrations in 72 marine sediment samples, collected from the inner shelf along the Sicilian coast (Gulfs of Palermo and Termini) and on the south-eastern coast of Lampedusa Island. These areas are characterised by different environmental conditions. On the basis of pollution sources and foraminiferal assemblages, we recognised different zones in the Gulf of Palermo. The most polluted zones showed high metal concentrations, and low diversity of benthic foraminifera with species typical of stressed environments. By c…
Targeting BCL-2 family proteins to overcome drug resistance in non-small cell lung cancer.
2007
Cytotoxic chemotherapies are standard of care for patients suffering from advanced non-small cell lung cancer (NSCLC). However, objective responses are only achieved in 20% of cases and long-term survival is rarely observed. Clinically applied anticancer drugs exert at least some of their activities by inducing apoptosis. A critical step in apoptotic signal transduction is the permeabilization of the mitochondrial outer membrane (MOM), which is regulated by the BCL-2 family of proteins. Hence, therapeutic targeting of BCL-2 proteins is a promising approach to increase the drug-sensitivity of cancers. To this end we have assessed the impact of conditional expression of the proapoptotic multi…
Personalization of Fast Conduction Purkinje System in Eikonal-Based Electrophysiological Models with Optical Mapping Data
2010
We present a pipeline for the personalization of model-based Purkinje fast conduction system using fast electrophysiological models and optical mapping data acquired from ex-vivo porcine hearts. The regional density of the Purkinje terminals as well as the latest endocardial activation time were the parameters personalized in an iterative procedure maximizing the similarity between the outcome of the electrophysiological simulations and measurements obtained from optical mapping data. We used a fast wave-front Eikonal-based electrophysiological model that generated the depolarization time maps that were subsequently compared with measurements at each iteration of the optimization stage. The…
Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery
2004
The influence of alloxan-induced diabetes on the reactivity of rabbit basilar artery to endothelin-1 was examined. Endothelin-1 induced concentration-dependent contraction of basilar arteries that was higher in diabetic than in control rabbits. Endothelium removal produced a higher enhancement of the endothelin-1-induced contraction in control than in diabetic rabbits. N(G)-nitro-L-arginine (L-NOArg) enhanced the maximal contraction induced by endothelin-1 in control rabbits and potentiated this response in diabetic rabbits. Endothelin ETA receptor antagonist, cyclo(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123), inhibited endothelin-1-induced contraction in both rabbit groups. Endothelin ETB receptor…
A novel pressure regulation system based on Banki hydro turbine for energy recovery under in-range and out-range discharge conditions
2021
Abstract Efficiency improvement of water distribution networks needs to be in place to guarantee a long life period under suitable operating conditions. Excessive pressure is among the well-known issues encountered in water distribution networks which can cause strength damages to the piping system. In order to overcome this drawback and to reach a suitable water pressure delivery, the present work suggests a novel pressure regulation system. This regulation system is consisting of a Banki turbine equipped with a mobile flap as a control device. The suggested pressure regulation system was experimentally and numerically investigated under in-range i.e. like actual water distribution network…
Exhaust Pipe Design Method for the Optimization of the Scavenging Process
1985
Conception des tuyauteries d'echappement en vue d'optimiser le balayage dans un moteur deux temps
A Banki–Michell turbine for in-line water supply systems
2017
The design of a novel Banki-Michell type turbine, to be located in existing water pipelines, is proposed. The turbine has a very efficient diffuser which allows the turbine to be compact and, most important, to have in-line flanges for minimal piping modifications at existing sites. This turbine combines a simple geometry with stable efficiency in a wide range of water discharges. The design procedure estimates the outer diameter of the impeller, its width and the geometry of the diffuser. A series of experimental tests has been carried out to measure the efficiency of the proposed turbine prototype. The turbine was tested in two different configurations, with and without rotational velocit…
New Computational Fluid Dynamic Procedure to Estimate Friction and Local Losses in Coextruded Drip Laterals
2007
The design of trickle irrigation systems is crucial to optimize profitability and to warrant high values for the emission uniformity (EU) coefficient. EU depends on variation of the pressure head due to head losses along the lines and elevation changes, as well as the water temperature, and other parameters related to the emitters (manufacturer's coefficient of variation, number of emitters per plants, emitter spacing). Trickle irrigation plants are usually designed using small diameter plastic pipes (polyethylene or polyvinyl chloride). The design problem, therefore, needs to consider head losses along the lines as well as emitter discharge variations due to the manufacturer's variability.…
Ability of Preissmann slot scheme to simulate smooth pressurisation transient in sewers
2010
Urban drainage networks are generally designed to operate in a free-surface flow condition. However, as a consequence of heavy rainfall events or network malfunctioning, filling of sewers (pressurization) and network overflowing may occur. Several softwares are commonly used to simulate floods in drainage networks and their results are usually thought to be reliable and robust. However, no specific studies have been carried out on the behaviour of these softwares during the pressurization transient. Actually, mathematical models based on the momentum equation appear to be more suitable in correctly simulating the pressurization moving jump but models based on the energy equation are much mo…
A novel visual pipework inspection system
2017
The interior visual inspection of pipelines in the nuclear industry is a safety critical activity conducted during outages to ensure the continued safe and reliable operation of plant. Typically, the video output by a manually deployed probe is viewed by an operator looking to identify and localize surface defects such as corrosion, erosion and pitting. However, it is very challenging to estimate the nature and extent of defects by viewing a large structure through a relatively small field of view. This work describes a new visual inspection system employing photogrammetry using a fisheye camera and a structured light system to map the internal geometry of pipelines by generating a photorea…