Search results for "PIP"

Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position

2022

Natural products are an excellent source of inspiration for the development of new drugs. Among them, betalains have been extensively studied for their antioxidant properties and potential application as natural food dyes. Herein, we describe the seven-step synthesis of new betalamic acid analogs without carboxy groups in the 2- and 6-position with an overall yield of ~70%. The Folin–Ciocalteu assay was used to determine the antioxidant properties of protected intermediate 21. Additionally, the five-step synthesis of betalamic acid analog 35 with three ester moieties was performed. Using NMR techniques, the stability of the obtained compounds towards oxygen was analyzed.

Linking woodland key habitat inventory and forest inventory data to prioritize districts needing conservation efforts

2012

Woodland key habitat (WKH) inventories have been conducted in northern European countries, with the aim to create networks of minimally disturbed forest stands for protection. The goal of national forest inventory is to provide information relevant to forest management, such as on forest types, trees species composition, age structure and wood volume. The aim of this study was to link these two inventory databases to identify districts of Latvia most deficient in connectivity and habitat quality, in order to prioritize districts needing conservation effort. As an example, the area of deciduous forest with nemoral tree species (oak, ash, lime, maple and elm) and aspen was chosen. These fores…

The role of traditional Erica arborea L. management practices in maintaining northeastern Sicily’s cultural landscape

2007

The tree heath (Erica arborea L.), a small evergreen tree found in the Mediterranean region and parts of Eastern and Central Africa, produces lignotubers that are highly valued for making smoking pipes. The Peloritani Mountains of northeastern Sicily are historically one of the most important areas in Italy for the production of these high quality lignotubers, known as briar root wood. In the past, tree heath shrublands were also an important source of charcoal. Erica arborea utilisation has declined dramatically during the past century, mostly due to the decreasing demand for smoking pipes, as well as the increasing frequency of wildfires and large-scale afforestation activities in this re…

Resistencia crítica / 2

2008

Experimental and Numerical Study on the Flow Field and Friction Factor in a Pressurized Corrugated Pipe

2015

An experimental campaign including measurement of pressure drops and velocity profiles was conducted on the pressurized flow in a commercial corrugated pipe. The results show that the empirical graphs suggested by Morris in the fifties may produce inaccurate assessments of the friction factor, in particular, for low Reynolds numbers. The experimental data was then reproduced by means of a numerical model with the large eddy simulation (LES) technique. The friction factor behavior for low and relatively high Reynolds numbers was thus investigated. The numerical simulations were in good agreement with the experimental results, showing the LES suitability to predict the effect of the pipe wall…

Analysis of Geometrical Relationships and Friction Losses in Small-Diameter Lay-Flat Polyethylene Pipes

2016

[EN] The use of lay-flat polyethylene pipes to irrigate horticultural crops has been receiving widespread attention in the last decade, due to the significant improvements in their hydraulic performance, their potentially high application efficiency, and their limited installation costs. However, even if hydraulic design procedures for conventional microirrigation systems are fairly well established, there is still the need to know how different pipe-wall thicknesses of lay-flat pipes can affect the pipe geometry under different operating pressures as well as the related consequences on friction losses. This paper, after comparing two different procedures (caliper and photographic) to asses…

Sistemi TEMPO-C60 come Catalizzatori Riciclabili Attivi nell’Ossidazione di Alcoli

2013

Catalytic Synergism in a C60IL10TEMPO2 Hybrid in the Efficient Oxidation of Alcohols

2014

A novel fullerene (5:1)hexakisadduct bearing two 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) radicals and ten 1-propyl-3-methylimida- zolium bromide moieties has been synthesized and characterized. Such an C60IL10TEMPO2 hybrid has been successfully employed as a catalyst in the se- lective oxidation of a wide series of alcohols and is highly active at just 0.1 mol% loading. Moreover, it can be easily recovered by adsorption onto a multi- layered covalently-linked SILP phase (mlc-SILP) through a "release and catch" approach and reused for up to 12 cycles without loss in efficiency. Inter- estingly, a catalytic synergistic effect of TEMPO and imidazolium bromide moieties combined in the same…

Ultra-High-Performance Liquid Chromatography Coupled with Quadrupole Orbitrap High-Resolution Mass Spectrometry for Multi-Residue Analysis of Mycotox…

2020

Cannabidiol (CBD) food supplements made of Cannabis sativa L. extracts have quickly become popular products due to their health-promoting effects. However, potential contaminants, such as mycotoxins and pesticides, can be coextracted during the manufacturing process and placed into the final product. Accordingly, a novel methodology using ultra-high-performance liquid chromatography coupled with quadrupole Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was developed to quantify 16 mycotoxins produced by major C. sativa fungi, followed by a post-target screening of 283 pesticides based on a comprehensive spectral library. The validated procedure was applied to ten CBD-bas…

Galectin-3 Impairment of MYCN-Dependent Apoptosis-Sensitive Phenotype Is Antagonized by Nutlin-3 in Neuroblastoma Cells

2012

MYCN amplification occurs in about 20-25% of human neuroblastomas and characterizes the majority of the high-risk cases, which display less than 50% prolonged survival rate despite intense multimodal treatment. Somehow paradoxically, MYCN also sensitizes neuroblastoma cells to apoptosis, understanding the molecular mechanisms of which might be relevant for the therapy of MYCN amplified neuroblastoma. We recently reported that the apoptosis-sensitive phenotype induced by MYCN is linked to stabilization of p53 and its proapoptotic kinase HIPK2. In MYCN primed neuroblastoma cells, further activation of both HIPK2 and p53 by Nutlin-3 leads to massive apoptosis in vitro and to tumor shrinkage an…