Search results for "PIR"
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Dabas materiālu izmantošana vidējā pirmsskolas vecuma bērnu sensorās attīstības sekmēšanai
2018
Darba autore: Unda Grūbe Kvalifikācijas darba temats: Dabas materiālu izmantošana vidējā pirmsskolas vecuma bērnu sensorās attīstības sekmēšanai. Darba mērķis: izzināt un pamatot dabas materiālu izmantošanas iespējas vidējā pirmsskolas vecuma bērnu sajūtu attīstības sekmēšanai. Autores izvirzītā hipotēze: vidējā pirmsskolas vecuma bērnu spēles ar dabas materiāliem sekmē sensoro attīstību, ja •pedagogs piedāvā dažādus dabas materiālus; •pedagogs ir paraugs bērnu darbībai un darbojas kopā ar viņu; •vecāki ir ieinteresēti, aktīvi iesaistās un atbalsta bērnu darbošanos ar dabas materiāliem. Pētījuma uzdevumi: 1.Analizēt teorētisko literatūru par sajūtām, to veidiem un attīstību pirmsskolas vecu…
Vidējā pirmsskolas vecuma bērnu personīgās higiēnas paradumu pilnveide pirmsskolas izglītības iestādes pedagoģiskā procesā
2020
Kvalifikācijas darba autors: Elīna Līckrastiņa Kvalifikācijas darba vadītājs: Dr. Paed., profesore Maruta Sīle Kvalifikācijas darba temats: vidējā pirmsskolas vecuma bērnu personīgās higiēnas paradumu pilnveide pirmsskolas izglītības iestādes pedagoģiskajā procesā. Pētījuma mērķis: pētīt vidējā pirmsskolas vecuma bērnu higiēnas paradumu pilnveidi pirmsskolas izglītības iestādes pedagoģiskajā procesā. Pētījuma hipotēze: higiēnas paradumu pilnveide vidējā pirmsskolas vecuma bērniem būs veiksmīgāka, ja: •pedagogs pārzinās bērnu vecumposmu likumsakarības; •atbilstoši bērnu interesēm un vajadzībām tiks plānots pedagoģiskais process dienas ritumā; •ja būs veiksmīga sadarbība starp pedagogu un vec…
Pircēja atbildības par dabasgāzes tirdzniecības līguma vienpusēju pirmstermiņa izbeigšanu
2022
Autors izvēlējies rakstīt darbu par pircēja atbildību par dabasgāzes tirdzniecības līguma vienpusēju pirmstermiņa izbeigšanu. Darba mērķis ir izpētīt nacionālo un Eiropas Savienības normatīvo regulējumu par pircēja kā dabasgāzes līguma slēdzēja atbildību par līguma pirmstermiņa izbeigšanu, gan pirms, gan pēc dabasgāzes tirgus liberalizācijas, kā arī iezīmēt tendences un virzienus iespējamā turpmākā atbildības regulējumā. Tēmas aktualitāte un reizē problemātika šobrīd ir augstais dabasgāzes cenu svārstību risks un resursa ierobežotā pieejamība tirgū. Tirgotājiem, lai nodrošinātu pircējiem piedāvāto dabasgāzes cenu, kā arī izvairītos no komercdarbības turpināšanai kritiskiem finanšu riskiem, …
Medical masks and Respirators for the Protection of Healthcare Workers from SARS-CoV-2 and other viruses
2020
The use of medical masks and respirators as personal protective equipment is pivotal to reducing the level of biological hazard to which healthcare workers are exposed during the outbreak of highly diffusible pathogens, such as the recent novel coronavirus SARS-CoV-2. Unfortunately, during this pandemic, supplies are rapidly running out worldwide, with potential consequences for the rate of occupational infections. Also, knowledge about specific characteristics of respirators is of utmost importance to select the proper type according to the clinical setting. A wide variety of literature is available on the topic, but mostly based on Influenza viruses infection models. Clinical evidence on …
Microstructural evaluation and recommendations for face masks in community use to reduce the transmission of respiratory infectious diseases
2022
Funding Information: A.K., H.Y. and R.J. also acknowledges the funding through Academy of Finland BESIMAL (Decision No. 334197) and Aalto University, Department of Communications and Networking. This work has also received funding in part from the EPSRC UK (grant number EP/R012091/1). A.K. would also like to thank Mr. Volkan Kaplan for the fruitful discussions in the early concept generation. Publisher Copyright: © 2022 The Author(s) Background and Objective: Recommendations for the use of face masks to prevent and protect against the aerosols (≤5µm) and respiratory droplet particles (≥5µm), which can carry and transmit respiratory infections including severe acute respiratory syndrome coro…
The Nasal Epithelium as a Factory for Systemic Protein Delivery
2002
We have previously shown that recombinant Sendai virus (SeV) produces efficient in vivo airway epithelial gene transfer. The ability to produce therapeutic levels of circulating proteins following noninvasive gene transfer would have widespread clinical application. Here, we compared nose, lung, and skeletal muscle for the ability to produce circulating levels of the secreted mouse antiinflammatory cytokine interleukin-10 (IL10) following SeV-mediated gene transfer. High levels of serum IL10 were obtained from each site with a potency order of lung > nose > muscle for a given viral titer. Serum levels from each site were within the likely required range for anti-inflammatory effects. The co…
Rapid and sensitive detection of metapneumovirus in clinical specimens by indirect fluorescence assay using a monoclonal antibody.
2008
Human metapneumovirus, with two known genotypes named A and B, is associated with mild respiratory symptoms to severe LRTI in children, high-risk adults and the elderly. Rapid and reliable methods of hMPV detection in clinical samples are essential to implement appropriate care, to better understand the pathology of hMPV and to determine its epidemiology. Respiratory samples from 1,386 patients collected during 2 consecutive years were screened for hMPV using indirect immunofluorescence (IFA) assay with a monoclonal antibody. Forty-three patients tested positive for hMPV by the IFA method. In parallel, the samples were examined with RT-PCR on the F gene. Of these, 41 specimens were RT-PCR p…
Immune responses during COVID-19 infection
2020
International audience; Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV (SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and 2015, and SARS-CoV-2 in 2020, have been causing severe and fatal human epidemics. The unpredictability of coronavirus disease-19 (COVID-19) poses a major burden on health care and economic systems across the world. This is caused by the paucity of in-depth knowledge of the risk factors for severe COVID-19, insufficient diagnostic tools for the detection of SARS-CoV-2, as well as the absence of specific and effective drug treatments. While protective humoral and cellular immune responses are usually m…
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
Antiviral prophylaxis in patients with haematological malignancies and solid tumours: Guidelines of the Infectious Diseases Working Party (AGIHO) of …
2006
Morbidity and mortality in patients with malignancies are increased by viral infections. These mostly are reactivations of asymptomatic latent infections. They primarily concern clinical entities associated with the reactivation of herpes viruses, such as varicella zoster virus (VZV) and cytomegalovirus (CMV). Respiratory tract infections caused by influenza, parainfluenza or respiratory syncytial virus (RSV) are less common. Since reactivation of latent infections has major clinical impact, antiviral prophylaxis is an attractive approach for patients expecting immunosuppression. The main risk factor for clinically relevant reactivation is profound disruption of cellular immune response. Du…