Search results for "PLASMA"
showing 10 items of 4043 documents
MMGBSA As a Tool To Understand the Binding Affinities of Filamin–Peptide Interactions
2013
Filamins (FLN) are large dimeric proteins that cross-link actin and work as important scaffolds in human cells. FLNs consist of an N-terminal actin-binding domain followed by 24 immunoglobulin-like domains (FLN1-24). FLN domains are divided into four subgroups based on their amino acid sequences. One of these subgroups, including domains 4, 9, 12, 17, 19, 21, and 23, shares a similar ligand-binding site between the β strands C and D. Several proteins, such as integrins β2 and β7, glycoprotein Ibα (GPIbα), and migfilin, have been shown to bind to this site. Here, we computationally estimated the binding free energies of filamin A (FLNa) subunits with bound peptides using the molecular mechan…
Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin β1, and Contributes to Melanomagenesis
2010
Filamin A (FLNA) is an integrator of cell mechanics and signaling. The spreading and migration observed in FLNA sufficient A7 melanoma cells but not in the parental FLNA deficient M2 cells have been attributed to FLNA. In A7 and M2 cells, the normal prion (PrP) exists as pro-PrP, retaining its glycosylphosphatidyl-inositol (GPI) anchor peptide signal sequence (GPI-PSS). The GPI-PSS of PrP has a FLNA binding motif and binds FLNA. Reducing PrP expression in A7 cells alters the spatial distribution of FLNA and organization of actin and diminishes cell spreading and migration. Integrin β1 also binds FLNA. In A7 cells, FLNA, PrP, and integrin β1 exist as two independent, yet functionally linked,…
The collagen receptor subfamily of the integrins
2003
The four collagen receptor integrins, alpha1beta1, alpha2beta1, alpha10beta1 and alpha11beta1, form a structurally and functionally distinct subgroup when compared to other members of the integrin family. In this review, we discuss the structures of these receptors and their differences in collagen binding and signalling function.
Wannier90 as a community code: new features and applications
2019
Wannier90 is an open-source computer program for calculating maximally-localised Wannier functions (MLWFs) from a set of Bloch states. It is interfaced to many widely used electronic-structure codes thanks to its independence from the basis sets representing these Bloch states. In the past few years the development of Wannier90 has transitioned to a community-driven model; this has resulted in a number of new developments that have been recently released in Wannier90 v3.0. In this article we describe these new functionalities, that include the implementation of new features for wannierisation and disentanglement (symmetry-adapted Wannier functions, selectively-localised Wannier functions, s…
Systems engineering activities supporting the heating & current drive and fuelling lines systems integration in the European DEMO breeding blanket
2019
This paper describes the contribution given by the application of the systems engineering approach to the European DEMO Breeding Blanket (BB) integration studies, focussing on the integration of Heating & Current Drive (H&CD) and Fuelling Lines (FL) systems. In particular, attention has been paid to the BB-H&CD and BB-FL interfaces identification, definition and capture of the proper interface requirements necessary to drive the integration process and, as a consequence, supply a feedback for the reciprocal design of the interconnected systems. The defined interfaces are synthetically described in the paper and the results of the interface requirements capture process are shown,…
The Spectrum of Ocular Manifestations in Patients with Waldenström's Macroglobulinemia.
2021
Purpose: To investigate the ocular manifestations in 91 Waldenstrom's macroglobulinemia (WM) patients.Methods: Retrospective, cross-sectional, observational analysis.Results: Ocular impairments, detected in 19 patients, included flame-shaped hemorrhages, venous sausaging, papilledema, macular detachments, or central retinal vein occlusion in 16 patients; paraproteinemic keratopathy in 2; and a CANOMAD syndrome in 1. Best-corrected visual acuity was ≥0.5 logMAR units in 11 of 38 eyes. Intraocular pressure was increased in seven eyes. Genetic analysis in seven patients showed a mutation in the MYD88 gene in six patients and a nonsense mutation in the CXCR4 gene in five patients. Plasmapheresi…
Space-Charge Effects with REXTRAP
2001
The beam quality of radioactive ion beams produced by present target ion source technology is often not sufficient for direct post-acceleration. Furthermore, pulsed beams insure a more efficient use of an accelerator. In the case of REX-ISOLDE, the post accelerator at the CERN ISOLDE facility, a gas-filled Penning trap (REXTRAP) has been chosen for accumulation of the radioactive ions and conversion into cooled bunches. Radial centering of the ions is achieved by applying an rf field with a frequency equal to the cyclotron frequency of the desired ion species. The efficiency achieved in the first tests with different isotopes covering nearly the entire mass range was already >20%. Going to …
Optimization of a hot-cavity type resonant ionization laser ion source
2015
TuePS05; International audience; Resonant Ionization Laser Ion Source (RILIS) is nowadays an important technique in many RadioactiveIon Beam (RIB) facilities for its reliability and ability to ionize efficiently and element selectively.Grand Accélérateur National d’Ions Lourds (GANIL) Ion Source using Electron Laser Excitation(GISELE) is an off-line test bench for RILIS developed to study a fully operational resonant laserion source at GANIL facility. The ion source body has been designed as a modular system toinvestigate different experimental approaches by varying the design parameters, to develop the futureon-line laser ion source. The aim of this project is to determine the best technic…
Prospects for quarkonium studies at the high-luminosity LHC
2020
Prospects for quarkonium-production studies accessible during the upcoming high-luminosity phases of the CERN Large Hadron Collider operation after 2021 are reviewed. Current experimental and theoretical open issues in the field are assessed together with the potential for future studies in quarkonium-related physics. This will be possible through the exploitation of the huge data samples to be collected in proton-proton, proton-nucleus and nucleus-nucleus collisions, both in the collider and fixed-target modes. Such investigations include, among others, those of: (i) J/psi and Upsilon produced in association with other hard particles; (ii) chi(c,b) and eta(c,b) down to small transverse mom…
Optimising the use of ICRF waves in JET hybrid plasmas for high fusion yield
2017
In the recent JET experimental campaign, good progress was made in the development of high-performance plasma scenarios compatible with the ITER-like wall (ILW). This paper reports on the optimisation of the use of ion cyclotron resonance frequency (ICRF) waves for the hybrid scenario in combination with neutral beam injection. The hybrid scenario is a candidate for ITER long-pulse operation. The combined NBI+ICRF power was increased to 33 MW and the record JET ILW fusion yield, averaged over 100 ms, from 2.3x1016 neutrons/s to 2.9x1016 neutrons/s with respect to the previous 2014 JET ILW fusion record. Impurity control with ICRF waves was one of the key means for extending the duration of …