Search results for "PLASMA"
showing 10 items of 4043 documents
Low density lipoproteins and human serum albumin as the carriers of squalenoylated drugs: insights from molecular simulations
2018
We have studied the interaction of three clinically promising squalenoylated drugs (gemcitabine-squalene, adenine-squalene, and doxorubicin-squalene) with low-density lipoproteins (LDL) by means of atomistic molecular dynamics simulations. It is shown that all studied squalenoylated drugs accumulate inside the LDL particles. This effect is promoted by the squalene moiety, which acts as an anchor and drives the hydrophilic drugs into the hydrophobic core of the LDL lipid droplet. Our data suggest that LDL particles could be a universal carriers of squalenoylated drugs in the bloodstream. Interaction of gemcitabine-squalene with human serum albumin (HSA) was also studied by ensemble of dockin…
Statistical correlation of fractional oscillator response by complex spectral moments and state variable expansion
2016
Abstract The statistical characterization of the oscillator response with non-integer order damping under Gaussian noise represents an important challenge in the modern stochastic mechanics. In fact, this kind of problem appears in several issues of different type (wave propagation in viscoelastic media, Brownian motion, fluid dynamics, RLC circuit, etc.). The aim of this paper is to provide a stochastic characterization of the stationary response of linear fractional oscillator forced by normal white noise. In particular, this paper shows a new method to obtain the correlation function by exact complex spectral moments. These complex quantities contain all the information to describe the r…
Principle and analytical applications of resonance lonization mass spectrometry
1989
Resonance ionization mass spectrometry (RIMS) is a very sensitive analytical technique for the detection of trace elements. This method is based on the excitation and ionization of atoms with resonant laser light followed by mass analysis. It allows element and, in some cases, isotope selective ionization and is applicable to most of the elements of the periodic table. A high selectivity can be achieved by applying three step photoionization of the elements under investigation and an additional mass separation for an unambiguous isotope assignment. An effective facility for resonance ionization mass spectrometry consists of three dye lasers which are pumped by two copper vapor lasers and of…
ANALYTICAL DETERMINATION OF INITIAL CONDITIONS LEADING TO FIRING IN NERVE FIBERS
2007
International audience; An analytical solution characterizing initial conditions leading to action potential firing in smooth nerve fibers is determined, using the bistable equation. In the first place, we present a nontrivial stationary solution wave, then, using the perturbative method, we analyze the stability of this stationary wave. We show that it corresponds to a frontier between the initiation of the travelling waves and a decay to the resting state. Eventually, this analytical approach is extended to FitzHugh-Nagumo model.
Atypical transistor-based chaotic oscillators: Design, realization, and diversity
2017
In this paper, we show that novel autonomous chaotic oscillators based on one or two bipolar junction transistors and a limited number of passive components can be obtained via random search with suitable heuristics. Chaos is a pervasive occurrence in these circuits, particularly after manual adjustment of a variable resistor placed in series with the supply voltage source. Following this approach, 49 unique circuits generating chaotic signals when physically realized were designed, representing the largest collection of circuits of this kind to date. These circuits are atypical as they do not trivially map onto known topologies or variations thereof. They feature diverse spectra and predom…
Quantum dissipative dynamics of a bistable system in the sub-Ohmic to super-Ohmic regime
2016
We investigate the quantum dynamics of a multilevel bistable system coupled to a bosonic heat bath beyond the perturbative regime. We consider different spectral densities of the bath, in the transition from sub-Ohmic to super-Ohmic dissipation, and different cutoff frequencies. The study is carried out by using the real-time path integral approach of the Feynman-Vernon influence functional. We find that, in the crossover dynamical regime characterized by damped \emph{intrawell} oscillations and incoherent tunneling, the short time behavior and the time scales of the relaxation starting from a nonequilibrium initial condition depend nontrivially on the spectral properties of the heat bath.
Response functions in multicomponent Luttinger liquids
2012
We derive an analytic expression for the zero temperature Fourier transform of the density-density correlation function of a multicomponent Luttinger liquid with different velocities. By employing Schwinger identity and a generalized Feynman identity exact integral expressions are derived, and approximate analytical forms are given for frequencies close to each component singularity. We find power-like singularities and compute the corresponding exponents. Numerical results are shown for the case of three components.
Breathers and solitons of generalized nonlinear Schrödinger equations as degenerations of algebro-geometric solutions
2011
We present new solutions in terms of elementary functions of the multi-component nonlinear Schr\"odinger equations and known solutions of the Davey-Stewartson equations such as multi-soliton, breather, dromion and lump solutions. These solutions are given in a simple determinantal form and are obtained as limiting cases in suitable degenerations of previously derived algebro-geometric solutions. In particular we present for the first time breather and rational breather solutions of the multi-component nonlinear Schr\"odinger equations.
Community detection algorithm evaluation with ground-truth data
2018
International audience; Community structure is of paramount importance for the understanding of complex networks. Consequently, there is a tremendous effort in order to develop efficient community detection algorithms. Unfortunately, the issue of a fair assessment of these algorithms is a thriving open question. If the ground-truth community structure is available, various clustering-based metrics are used in order to compare it versus the one discovered by these algorithms. However, these metrics defined at the node level are fairly insensitive to the variation of the overall community structure. To overcome these limitations, we propose to exploit the topological features of the ‘communit…
Liquidity-adjusted value-at-risk optimization of a multi-asset portfolio using a vine copula approach
2019
Abstract This paper develops a novel approach to assess liquidity-adjusted Value-at-Risk (LVaR) optimization of multi-asset portfolios based on vine copulas and LVaR models. This framework is applied to stock markets of the G-7 countries, gold, commodities and Bitcoin. The results show that our approach is superior to the classical mean–variance Markowitz portfolio technique in terms of the optimal portfolio selection under a number of realistic operational and budget constraints. We find that both Bitcoin and gold improves the risk-return performance of the G-7 stock portfolio. However, Bitcoin (gold) performs better under a scenario of only long-positions (when short-selling is allowed).