Search results for "PLASMA"
showing 10 items of 4043 documents
Plasma Viscosity and NLR in Young Subjects with Myocardial Infarction: Evaluation at the Initial Stage and at 3 and 12 Months
2018
In the “Sicilian study on juvenile myocardial infarction,” we had evaluated plasma viscosity (PV) and neutrophil/lymphocyte ratio (NLR) in patients with acute myocardial infarction (AMI) at the age of ⩽45 years. Now, we examined the relationship between these 2 parameters in 120 subjects (109 men and 11 women) aged ⩽45 years with recent AMI. The patients were classified according to the number of cardiovascular risk factors, the electrocardiographic criteria (ST-segment elevation myocardial infarction [STEMI] or non-ST-segment elevation myocardial infarction [NSTEMI]), and the extent of coronary stenosis, evaluated with coronary angiography. On fasting venous blood, we measured PV at the sh…
Experimental Analysis of Velocity Distribution in a Coarse-Grained Debris Flow: A Modified Bagnold’s Equation
2020
Today, Bagnold&rsquo
Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1
2018
Immunomodulatory drugs and monoclonal antibody-based immunotherapies have significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent years. These new classes of reagents target malignant plasma cells (PCs) and further modulate the immune microenvironment, which prolongs anti-MM responses and may prevent tumor occurrence. Since MM remains an incurable cancer for most patients, there continues to be a need to identify new tumor target molecules and investigate alternative cellular approaches using gene therapeutic strategies and novel treatment mechanisms. Osteoclasts (OCs), as critical multi-nucleated large cells responsible for bone destruction in >80% …
IFI16 expression is related to selected transcription factors during B-cell differentiation
2015
The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation of B- and T-cells. We explored the role of IFI16 in normal B-cell subsets by analysing its expression and relationship with the major transcription factors involved in germinal center (GC) development and plasma-cell (PC) maturation.IFI16mRNA was differentially expressed in B-cell subsets with significant decrease inIFI16mRNA in GC and PCs with respect to naïve and memory subs…
Hemostasis and ageing
2008
Abstract On March 19, 2008 a Symposium on Pathophysiology of Ageing and Age-Related Diseases was held in Palermo, Italy. The lecture of D. Mari on Hemostasis and ageing is summarized herein. Physiological ageing is associated with increased plasma levels of many proteins of blood coagulation together with fibrinolysis impairment. This may be of great concern in view of the known association between vascular and thromboembolic diseases and ageing. On the other hand, centenarians are characterized by a state of hypercoagulability and possession of several high-risk alleles and well-known atherothrombotic risk markers but this appears to be compatible with longevity and/or health. Parameters c…
New Insight into Immunity and Immunopathology of Rickettsial Diseases
2011
Human rickettsial diseases comprise a variety of clinical entities caused by microorganisms belonging to the generaRickettsia,Orientia,Ehrlichia, andAnaplasma. These microorganisms are characterized by a strictly intracellular location which has, for long, impaired their detailed study. In this paper, the critical steps taken by these microorganisms to play their pathogenic roles are discussed in detail on the basis of recent advances in our understanding of molecularRickettsia-host interactions, preferential target cells, virulence mechanisms, three-dimensional structures of bacteria effector proteins, upstream signalling pathways and signal transduction systems, and modulation of gene exp…
Influence of Biomass Combustion Products on Element Content and Thermal Stability of Latvian Sheep Breed Wool Filter Fibres
2020
Sheep wool is natural, easy obtainable, renewable and biodegradable material with a perspective application as a sorbent in filters for purification of industrial emissions from various environmental pollutants. The element content and thermal stability of Latvian dark-headed sheep wool filter fibres was analysed and described before and after exposure to biomass combustion products. Based on the obtained results, it is concluded that the sheep wool filter fibres can sorb various gaseous combustion products, such as carbon monoxide (CO), carbon dioxide (CO2) and nitrogen oxides (NOx), however, the sorption processes of these gases are irreversible. The obtained results of total reflection X…
Leptin plasma levels in patients undergoing prostate biopsy. a preliminary study in 50 patients
2013
Introduction/Aim: To reduce the number of negative prostate biopsies and to detect clinical significant prostate tumors in patients with elevated serum PSA represent major challenges in urological oncology. Prostate tumors diagnosed in patients with elevated Body Mass Index (BMI) show higher Gleason score and more aggressive biological behavior than those diagnosed in normal population (1). Elevated plasma levels of leptin and other adipose tissue derived factors (adipokines), are evident in obese men (2). Many studies have investigated the role of leptin as a putative molecular mediator between obesity and prostate cancer with contradictory results. Also in normal or overweight (BMI <30) m…
Searches for lepton number violation and resonances in K± → πμμ decays
2017
The NA48/2 experiment at CERN collected a large sample of charged kaon decays to final states with multiple charged particles in 2003–2004. A new upper limit on the rate of the lepton number violating decay K±→π∓μ±μ± is reported: B(K±→π∓μ±μ±)<8.6×10−11 at 90% CL. Searches for two-body resonances X in K±→πμμ decays (such as heavy neutral leptons N4 and inflatons χ ) are also presented. In the absence of signals, upper limits are set on the products of branching fractions B(K±→μ±N4)B(N4→πμ) and B(K±→π±X)B(X→μ+μ−) for ranges of assumed resonance masses and lifetimes. The limits are in the (10−11,10−9) range for resonance lifetimes below 100 ps.
Complex dynamics, hidden attractors and continuous approximation of a fractional-order hyperchaotic PWC system
2018
In this paper, a continuous approximation to studying a class of PWC systems of fractionalorder is presented. Some known results of set-valued analysis and differential inclusions are utilized. The example of a hyperchaotic PWC system of fractional order is analyzed. It is found that without equilibria, the system has hidden attractors.