Search results for "PLATE"
showing 10 items of 1689 documents
IMPLICIT MESH DISCONTINUOUS GALERKIN FOR VARIABLE ANGLE TOW MULTILAYERED PLATES
2018
This works presents a novel computational scheme for variable angle tow (VAT) multilayered plates [1]. The characteristic features of the proposed scheme are the combined use of a discontinuous Galerkin (dG) formulation and an implicitly defined mesh. The formulation is based on the principle of virtual displacements (PVD) and the Equivalent Single Layer (ESL) assumption for the mechanical behavior of the VAT plates [2]. The problem is first placed within the dG framework by suitably introducing an auxiliary variable and by rewriting the set of equations governing ESL VAT plates as a firstorder system of differential equations. Following Arnold et al.[3] and by introducing suitably defined …
Noticias sobre el platero valenciano Estanislau Martínez (1731-1775) y su familia
2003
Los Martínez Josep, Estanislau, Ferran e Ignasi forman una de las más destacadas familias de plateros del siglo XVIII valenciano. Todos los cuatro tienen obrador independiente y contratan obras, algunas de las cuales se conservan in situ. Con este artículo intentamos una primera aproximación general a sus vidas y obras. (A)
Metal Displacement Deposition: a facile via to grow metal and metal oxide nanostructures
2010
Nanostructured materials have received increasing attention because of their high chemical reactivity that allows an extensive use in many fields, like catalysis, electrosynthesis, sensors, and so on [1]. Taking into account that size plays a fundamental role for the properties of nanostructures, it is of relevant importance for their applications to develop a facile method of synthesis. In our previous works, we have described a template synthesis of metal nanowires through a simple novel route [2-4]. In particular, using a combination of template deposition and metal displacement reaction, we have fabricated pure metal nanowires with a well-defined morphology. This type of template synthe…
In vitro and in vivo characterization of a new organic nitrate hybrid drug covalently bound to pioglitazone.
2014
<b><i>Background/Aims:</i></b> Organic nitrates represent a group of nitrovasodilators that are clinically used for the treatment of ischemic heart disease. The new compound CLC-3000 is an aminoethyl nitrate (AEN) derivative of pioglitazone, a thiazolidinedione antidiabetic agent combining the peroxisome proliferator-activated receptor &#947; agonist activity of pioglitazone with the NO-donating activity of the nitrate moiety. <b><i>Methods:</i></b> In vitro and in vivo characterization was performed by isometric tension recording, platelet function, bleeding time and detection of oxidative stress. <b><i>Results:</i></…
Could resveratrol be a useful drug for the treatment of malignant hemopathies?
2013
Resveratrol is a poly-phenol with many beneficial effects: not only as an antioxidant, anti-inflammatory, and antiatherogenic agent, as well as a platelet aggregation inhibitor, but also as an antiproliferative and proapoptotic factor in various types of cancers. There are reviews about the mechanisms responsible for its effects in leukemia and lymphomas, emphasizing the chemosensitizing role of resveratrol, which allows overcoming the multidrug resistance of cancers. The action of resveratrol occurs preferentially on leukemic cells, and not on the normal ones. In addition, it is one of the few drugs that act on leukemic stem cells. If experimental results are promising, its application in …
Number of drugs used in secondary cardiovascular prevention and late survival in the population of Valencia Community, Spain.
2019
Abstract Background Drug treatment for secondary prevention of cardiovascular disease is recommended by guidelines, but it is not always followed in real life. This study wanted to assess the size of this gap and its impact on mortality in subjects after a cardiovascular event (MACE). Methods Patients with any of MACE in the period from January 1st 2011 to December 31st 2013, and more than one year of follow-up were selected from population of the Valencian Community. Drugs for secondary prevention were antiplatelets, renin-angiotensin system blockers and statins. Assessment of treatment was performed one year after the initial event. Mortality risk was assessed using Cox by the number of d…
Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid.
2012
A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS). Limited bioequivalence (BE) studies reported in the literature indicate that products that have been tested are bioequivalent. Most of the excipients used in products with a marketing authorization in Europe are not considered to have an impact on gastrointestinal motility or permeability. Furthermore, ASA has a wide therapeutic index. Thus, the risks to the patient that might occur if a nonbioequi…
Tendencia en la utilización de antiagregantes en la Comunidad Valenciana (2000-2005)
2007
Beatriz Román Llamosí, Rocío Broseta Solaz, Joan Quiles Izquierdo y Amalia Úbeda Pascual (Amalia.Ubeda@uv.es) Los antiagregantes plaquetarios son fármacos básicos para la prevención de enfermedades isquémicas arteriales. El objetivo de este trabajo es conocer la evolución de su utilización en Atención Primaria en la Comunidad Valenciana durante el periodo 2000-2005. Métodos: Estudio descriptivo del consumo de los antiagregantes plaquetarios (código ATC: B01AC) dispensados con cargo al Sistema Nacional de Salud en la Comunidad Valenciana en el ámbito de Atención Primaria. Datos expresados en dosis diarias definidas (DDD) por 1.000 habitantes y día. Resultados: En 2005 tres fármacos represent…
Modeling the aerosol chemical composition of the tropopause over the Tibetan Plateau during the Asian summer monsoon
2019
Enhanced aerosol abundance in the upper troposphere and lower stratosphere (UTLS) associated with the Asian summer monsoon (ASM) is referred to as the Asian Tropopause Aerosol Layer (ATAL). The chemical composition, microphysical properties, and climate effects of aerosols in the ATAL have been the subject of discussion over the past decade. In this work, we use the ECHAM/MESSy Atmospheric Chemistry (EMAC) general circulation model at a relatively fine grid resolution (about 1.1×1.1∘) to numerically simulate the emissions, chemistry, and transport of aerosols and their precursors in the UTLS within the ASM anticyclone during the years 2010–2012. We find a pronounced maximum of aerosol extin…
MULTICRITERIA OPTIMAL DESIGN OF CONTINUOUS CIRCULAR PLATES
2010
The paper is devoted to a quite general version of the multicriteria optimal (minimum volume) design of axisymmetric circular plates. The constitutive material is considered as elastic perfectly plastic without any ductility limit and the actions are assumed as quasi-statically variable within a given load domain. In the design problem formulation different resistance criteria are considered, in order to investigate all the possible structural limit responses, and for each one a suitably chosen safety factor is chosen. The optimal design problem is formulated as the search for the minimum structure volume according with a statical approach. The features of the optimal structures will be stu…