Search results for "PLC"
showing 10 items of 242 documents
Synthesis of 8-aminomorphans with high KOR affinity
2021
2-Azabicyclo[3.3.1]nonanes (morphans) with a (3,4-dichlorophenyl)acetyl group at 2-position and a pyrrolidino moiety at 8-position were designed as conformationally restricted analogs of piperidine-based KOR agonists. The synthesis started with 4-oxopiperidine-2-carboxylic acid comprising 13 reaction steps. At first the ketone 10 was transformed into diester 7 bearing a propionate side chain. Dieckmann condensation of diester 7 to afford bicyclic enolester 14 and subsequent Krapcho deethoxycarbonylation represent the key steps of the synthesis. The enantiomeric pyrrolidines (1S,5R,8R)-5a and (1R,5S,8S)-5a were separated by chiral HPLC. The eutomer (1S,5R,8R)-5a showed high KOR affinity (K-i…
On the solutions to 1-Laplacian equation with L1 data
2009
AbstractIn the present paper we study the behaviour, as p goes to 1, of the renormalized solutions to the problems(0.1){−div(|∇up|p−2∇up)=finΩ,up=0on∂Ω, where p>1, Ω is a bounded open set of RN (N⩾2) with Lipschitz boundary and f belongs to L1(Ω). We prove that these renormalized solutions pointwise converge, up to “subsequences,” to a function u. With a suitable definition of solution we also prove that u is a solution to a “limit problem.” Moreover we analyze the situation occurring when more regular data f are considered.
Loading profile of topotecan into polyvinyl alcohol microspheres (DC Bead™) over a 7-day period
2011
Purpose: DC Bead™ is successfully used for chemoembolization of various liver cancers. The purpose of this study was todetermine the loading capacity of the semi-synthetic topoisomerase-1 inhibitor topotecan into the DC Bead™ microspheres under static or agitated conditions and to assess the physicochemical stability over a period of 7 days. Methods: Commercially available topotecan hydrochloride powder (Hycamtin®) was reconstituted with water for injection to yield a nominal concentration of 1 mg/mL topotecan. Polyvinyl alcohol (PVA)-based microspheres (DC Bead™, 300–500 µm, 2 mL/vial) were mixed with 4 mL of the reconstituted topotecan solution. Vials were stored light protected at room …
Advances in the analysis of legal and illegal drugs in the aquatic environment
2013
We review the current methods developed for the analysis of legal and illegal drugs (LIDs) and their metabolites in environmental samples. We discuss the advantages and the pitfalls of multi-class methods with emphasis on new strategies for sample preparation and recent technical developments. Finally, we present the applicability of these methods to the analysis of LIDs in protected environmental areas.
Enantiomerization of an inherently chiral resorcarene derivative: determination of the interconversion barrier by computer simulation of the dynamic …
2001
Abstract The inherently chiral tetrabenzoxazine resorcarene derivative 1 shows characteristic plateau-formation during enantioselective HPLC separation on the chiral stationary phase Chiralpak AD. By computer assisted peak form analysis of the elution profiles, obtained from temperature dependent dynamic HPLC (DHPLC) experiments, with ChromWin, the enantiomerization barrier Δ G # (298 K)=92±2 kJ mol −1 and the activation parameters Δ H # =53.0±1.8 kJ mol −1 and Δ S # =−131±14 J (K mol) −1 were determined.
Secondary substation power line communications for medium voltage smart grids
2012
In this paper a performance analysis is carried out, in order to evaluate the possibility to employ power line communication (PLC) between secondary substations of a medium voltage (MV) distribution networks in a smart grid. The study is focused on the analysis of PLC technologies and the evaluation of the influence quantities on the communication performance in the most common case of by-pass connection at MV bus-bars of secondary substations. Different quantities have been analyzed as modulation techniques, requested bandwidth and bitrate, coupling device and system attenuation versus frequency in order to find the best solution for a reliable communication system. A complete model of a r…
Hardware-in-the-loop implementation for an active heave compensated drawworks
2012
Published version of an article published in the journal: Central European Journal of Engineering. Also available from the publisher at: http://dx.doi.org/10.2478/s13531-011-0062-1 This paper presents the setup and running of a hardware-in-loop (HIL) simulation for an active heave compensated (AHC) draw-works. A simulation model of the draw-works is executed on a PC to simulate the AHC draw-works with a physical PLC. The PLC (ET200S) is configured with a controller architecture that regulates the motor angular displacement and velocity through actuation of the servo valves. Furthermore, a graphical user interface is developed for operation of the AHC system. The HIL test allowed tuning of t…
Oil filled MV/LV Power Transformer Behavior in Narrow Band Power Line Communication Systems
2012
The aim of this paper is to characterize oil-filled power transformers in the narrow-band power-line communication (PLC) frequency range of 50-150 kHz. A new model is proposed for such type of a transformer, in the aforementioned frequency range of interest, in order to study its influence on the signal transmission and to investigate the possibility that the PLC signal can cross the power transformer itself. The new model is simpler than those previously proposed in literature, and it can be used in the whole frequency range available for NB PLC according to the CENELEC EN 50065-1 A-band. In order to validate the model, simulation and measurement results are compared for four oil-filled po…
On the use of narrow band power line as communication technology for medium and low voltage smart grids
2012
The aim of this work is to perform a feasibility study on the power line communication for the development of a new generation of interface devices (IDs) for smart grid applications. More in detail, this paper deals with one of the most important issues on this topic which is the communication system. Among the existing communication technologies, the study is focused on power line communications (PLCs). After a analysis of the state of the art in the field, the main aspects are analyzed, concerning the open issues on the use of PLCs, especially for medium voltage (MV) and low voltage (LV) systems. In this work the use of PLC in MV-LV networks is investigated, by means of simulations and ex…
Using the Microcontroller and the PLC in a RPP Robot Control
2012
This paper presents some aspects regarding the possibility of combining microcontroller and programmable logic controller (PLC) for robot control. The RPP robot is designed and manufactured within the Faculty of Engineering from “Lucian Blaga” University of Sibiu, as a patent: BRAŢ TELESCOPIC, Nr. 112418 B1, Int.CI.6 B 25 J 18/02, from 17.02.1997. Classical systems for programming and control of industrial robot are based on numerical control equipment, developed around a PC. Programmable Logic Controllers (PLC) haves proven to be viable alternatives to driving machine tools, industrial systems and Robots. Microcontrollers as computers offer advantage due to programmable inputs and outputs …