Search results for "PMA"
showing 10 items of 118 documents
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
2022
Background & aims: Activation of Kupffer cells and recruitment of monocytes are key events in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic stellate cells (HSCs), the main fibrogenic cell type within the liver. Mer tyrosine kinase (MerTK) signaling regulates multiple processes in macrophages and has been implicated in the pathogenesis of non-alcoholic steatohepatitis-related fibrosis. In this study, we explored if MerTK activation in macrophages influences the profibrogenic phenotype of HSCs. Methods: Macrophages were derived from THP-1 cells or differentiated from peripheral blood monocytes towards MerTK+/CD206+/CD163+/CD209- macrophages. Th…
Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors
2018
Tumors are characterized by leaky blood vessels, and by an abnormal and heterogeneous vascular network. These pathophysiological characteristics contribute to the enhanced permeability and retention (EPR) effect, which is one of the key rationales for developing tumor-targeted drug delivery systems. Vessel abnormality and heterogeneity, however, which typically result from excessive pro-angiogenic signaling, can also hinder efficient drug delivery to and into tumors. Using histidine-rich glycoprotein (HRG) knockout and wild type mice, and HRG-overexpressing and normal t241 fibrosarcoma cells, we evaluated the effect of genetically induced and macrophage-mediated vascular normalization on th…
The barratry of the shipmaster in early modern law: polysemy and mos Italicus
2019
Summary ‘Barratry’ is a polysemic term: it means deceit, bribe, simony, and fraud of the shipmaster. This article seeks to trace the origins of the word and to explore its different meanings, focusing especially on the influence that older meanings had on the development of more recent ones. This operation is of particular importance to understand the meaning of barratry that would appear for last – that of fraud of the shipmaster. By the time civil lawyers started dealing with maritime barratry, they were already well familiar with the other meanings of the term. This probably favoured the adaptation process, but it also left a deep mark on its outcome: the weight of those other meanings o…
The Barratry of the Shipmaster in Early Modern Law: The Approach of Italian and English Law Courts
2019
Summary For a long time, the concept of barratry (at least in its maritime meaning) was one and the same on both sides of the Channel. The barratry of the shipmaster was part of the mercantile usages, and it identified the intentionally blameworthy conduct of the master. When law courts began to decide on insurance litigation they were confronted with a notion quite alien to them. Broadly speaking, the shipmaster’s barratry could well be considered a fraud of sort. But in order to decide on its occurrence in a specific case, law courts had to analyse it in legal terms, and so according to the specific legal categories of their own system. The point ceases to be trivially obvious if we think…
Hibrīd-decentralizēta vienādranga failu apmaiņa Interneta pārlūkprogrammās
2018
Nodrošinot failu apmaiņas tiešsaistes pakalpojumus, būtisku resursu patēriņu rada tīkla slodze uz pakalpojuma sniedzēja infrastruktūru. Šobrīd lielākā daļa šādu pakalpojumu izmanto centralizētu klienta-servera arhitektūru. Lai samazinātu slodzi, ir iespējams aizvietot klasisko klienta-servera arhitektūru ar hibrīd-decentralizētu vienādranga arhitektūru. Tādējādi tiktu izmantoti klientu resursi pakalpojuma sniegšanā. Darba mērķis ir teorētiski analizēt iespējas un ierobežojumus hibrīd-decentralizētai vienādranga failu apmaiņai Interneta pārlūkprogrammās un praktiski realizēt šādu lietotni. Darbā ir izstrādāta lietotne, izmantojot BitTorrent un WebRTC protokolus, un ir ieviesta ražošanā esošā…
Il dovere di soccorso in mare e il diritto di obbedire al diritto (internazionale) del comandante della nave privata
2019
Shipmasters are commonly considered the addressees of an international legal duty to rescue at sea. This article describes the evolution of international law in this field, from the first maritime conventions of the 1910's to the IMO Safety Committee's resolutions of the 2010's. It then argues that behind the duty to rescue there is a hidden right of the shipmaster. This right has a moral pedigree and is functional to the full compliance of the duty itself. It can be enforced in the national legal order against any State (or private entity) that tries to obstruct the shipmaster's activities of assistance or to penalize her or him for the assistance given. National judges enforce this right …
The case for strategic international alliances to harness nutritional genomics for public and personal health
2005
Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need …
PMA E BIOLOGIA FORENSE IN AUSILIO DEL PUBBLICO MINISTERO
2012
PMA E BIOLOGIA FORENSE IN AUSILIO DEL PUBBLICO MINISTERO Carra E., Di Natale M.V. Dipartimento di Scienze Tecnologie Molecolari Biomolecolari (STEMBIO)– Università di Palermo Edifio 16, viale delle Scienze.– elena.carra@unipa.it Nell’ambito di attività svolta su incarico dell’Autorità Giudiziaria si è proceduto all’inventario del contenuto di fusti per la crioconservazione di gameti ed embrioni sottoposti a sequestro e custoditi presso i locali di quattro centri di biologia della riproduzione per “verificarne la rispondenza alle registrazioni cartacee ed informatiche acquisite agli atti”. Si rendeva, altresì, necessaria analisi genetica su materiale biologico, costituito da embrione umano d…
The effect of montmorillonite clay in alginate gel beads for polychlorinated biphenyl adsorption: Isothermal and kinetic studies
2014
Beads of alginate montmorillonite have been used as sorbent for polychlorinated biphenyls from aqueous solutions.The structure and the differences between the different beads were established by IR spectroscopy (FT-IR). The adsorption at 25 °C has been studied in a batch system, following its kinetics and assessing adsorbent dose, initial PCB concentrations, and pH effects. The results show that increasing the initial concentration of the PCBs and the adsorption time favored the adsorption. Adsorption isotherm data were modeled using Chapman, Freundlich and Langmuir adsorption isotherms and the appropriate parameters were calculated.Adsorption of trichlorobiphenyls on alginate–montmorilloni…
Latvijas Bibliotekāru biedrība un profesionālie pieredzes apmaiņas pasākumi kopš darbības atjaunošanas
2019
Pētījuma “Latvijas Bibliotekāru biedrība un profesionālie pieredzes apmaiņas pasākumi kopš darbības atjaunošanas” mērķis ir izpētīt LBB organizētos profesionālos pieredzes apmaiņas pasākumus, to tematiku un apmeklētību laika posmā no darbības atjaunošanas 1989. gadā līdz 2018. gadam, jo plaši pieejamā apkopojošā informācija ir nepietiekama. Bakalaura darbs izstrādāts, pētot mācīšanās, sociālo tīklu un tās atzara – sociālā kapitāla – teorijas, analizējot iepriekš veiktus tematiski saistītus pētījumus un veicot LBB pārstāvju intervijas, arhīva dokumentu un nozares publikāciju analīzi un LBB pasākuma apmeklētāju anketēšanu, kā rezultātā apkopoti un analizēti LBB un tās reģionālo nodaļu un tema…