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RESEARCH PRODUCT
The case for strategic international alliances to harness nutritional genomics for public and personal health
Jean-philippe JaisLin HeMatthew A. RobertsMichael C. ArcherMitchell M. KanterGertrud U. SchusterTaesun ParkKaisa PoutanenBruce GermanJose M. OrdovasWarren C. McnabbSusan J. Fairweather-taitIvana Beatrice Manica Da CruzPaul TrayhurnCraig A. CooneySu-ju LinRosane CaetanoDenis R. LaurenWillard J. VisekMichael MayneCraig H WardenRicardo UauyDolores CorellaWim H. M. SarisBruce R. KorfRuth ChadwickJim KaputNorma Ana PenselFrans Van Der OuderaaJohn K. WienckeRuan M. ElliottBen Van OmmenJan-åke GustafssonYangsoo JangMichael J. GibneyTroy DusterSven O. E. EbbessonRuth BirkFrancisco Pérez-jiménezMichael FenechDavid CastleDavid W. KrempinRonald M. KraussKenneth S. KornmanJae-kwan HwangKenneth H. BrownRosalynn Gill-garrisonLynnette R. FergusonClaudine JunienKent J. BradfordGillies Peter JohnJohn C. MathersXi Zhao-wilsonMichael MüllerJohn L. HartmanYuri NikolskyJong Ho LeeBerthold KoletzkoSue SouthonKarine ClémentAndrew N. ShellingPeter J. Van BladerenJim FeltonJohn W. FinleyStephen L. ClarkeBruce N. AmesHans JoostGilbert A. LeveilleStephen BarnesJean-daniel ZuckerBradford TowneWarren A. KibbeNancy Fogg-johnsonPeter MorganRaymond L. RodriguezE. Shyong TaiAmelia BartholomewKevin DawsonWasyl MalyjJack WinklerDominique LanginJohn A. MilnerRick WeissLindsay H. AllenHannelore DanielGeorge L. WolffArtemis P. Simopoulossubject
Knowledge managementNutritional genomicsBiomedical Researchgenetic association030309 nutrition & dieteticsgenotypeInternational CooperationMedicine (miscellaneous)Variation (Genetics)Human genetic variationmedical researchgene–nutrient interactionsVoeding Metabolisme en GenomicaEatingNutrigenomicsenvironmental factorgenetic variabilityGlobal healthNutritional Physiological PhenomenaHealth diaparitiesimmune function2. Zero hunger0303 health sciencesNutrition and Dieteticsstrategic international alliancesarticleGenomicsdiabetes-related traitsdietary fiberHealth equityMetabolism and Genomics3. Good healthNutrigenomicsmessenger-rnaHealthMetabolisme en Genomica/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingNutrition Metabolism and Genomicshealth diaparitiesmedicine.medical_specialtyResearch programhapmap projectpopulation stratificationheredityphenotypeBiologyEnvironmentStrategic international alliancesnutritional health03 medical and health sciencesGene interactionnutrigenomicsSDG 3 - Good Health and Well-beingVoedingmedicineAnimalsHumanscomplex diseaseshuman030304 developmental biologygene identificationVLAGNutritionnonhumanbusiness.industryGenome HumanPublic healthResearchGenetic Variationpopulation geneticsGene-nutrient interactionscultural factorNutrition PhysiologyBiotechnologyDisease Models AnimalHarnessmolecular geneticsbusinessdietary intakepublic health servicecoronary-heart-diseasecarbohydrate ingestiondescription
Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries. © The Authors 2005.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-01-01 | British Journal of Nutrition |