Search results for "PMA"

Bayesian model to detect phenotype-specific genes for copy number data

2012

Abstract Background An important question in genetic studies is to determine those genetic variants, in particular CNVs, that are specific to different groups of individuals. This could help in elucidating differences in disease predisposition and response to pharmaceutical treatments. We propose a Bayesian model designed to analyze thousands of copy number variants (CNVs) where only few of them are expected to be associated with a specific phenotype. Results The model is illustrated by analyzing three major human groups belonging to HapMap data. We also show how the model can be used to determine specific CNVs related to response to treatment in patients diagnosed with ovarian cancer. The …

Population differences in the International Multi-Centre ADHD Gene Project.

2008

Contains fulltext : 71443.pdf (Publisher’s version ) (Closed access) The International Multi-Centre ADHD Gene sample consists of 674 families from eight countries (Belgium, England, Germany, Holland, Ireland, Israel, Spain, and Switzerland) ascertained from clinics for combined-type attention definity hyperactivity disorder in an offspring. 863 SNPs were successfully genotyped across 47 autosomal genes implicated in psychiatric disorders yielding a single nucleotide polymorphism (SNP) density of approximately one SNP per 2.5 kb. A global test of heterogeneity showed 269 SNPs nominally significant (expected 43). Inclusion of the Israeli population accounted for approximately 70% of these nom…

Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies

2012

Background— Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results— Continuous ABI and PAD (ABI ≤0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the ≈2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fi…

Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder

2010

Contains fulltext : 87688.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. As prior genome-wide association studies (GWAS) have not yielded significant results, we conducted a meta-analysis of existing studies to boost statistical power. METHOD: We used data from four projects: a) the Children's Hospital of Philadelphia (CHOP); b) phase I of the International Multicenter ADHD Genetics project (IMAGE); c) phase II of IMAGE (IMAGE II); and d) the Pfizer-funded study from the…

Blokķēdes izmantošana kā trešā puse godīgas apmaiņas problēmā

2017

Godīgas apmaiņas teorijas ieviešanai praksē ir bijusi otršķirīga loma, jo veicot apmaiņu ar digitālām lietām parasti abas puses sevi identificē un uzticības latiņa ir augsta, turklāt bankas vajadzības gadījumā var iejaukties negodīgos darījumos. Izmantojot blokķēžu tehnoloģiju tiek veidotas decentralizētas un anonīmas maksājumu sistēmas - tās var izmantot noziedzinieki un tajās nav iespējas atcelt maksājumus. Godīgai apmaiņai šādos apstākļos ir liela nozīme. Darbā tiks aplūkota praktiska problēma, kur hakeri ar izspiedējvīrusa palīdzību nošifrē upura datus un pieprasa izpirkumu kriptovalūtā. Tiks aplūkots veids, kā padarīt upurim šo apmaiņu godīgu.

Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia.

2017

Daniel Gündel,1 Mareli Allmeroth,2 Sarah Reime,1 Rudolf Zentel,2 Oliver Thews1 1Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle (Saale), 2Institute of Organic Chemistry, Johannes Gutenberg-University, Mainz, Germany Background: Polymeric nanoparticles allow to selectively transport chemotherapeutic drugs to the tumor tissue. These nanocarriers have to be taken up into the cells to release the drug. In addition, tumors often show pathological metabolic characteristics (hypoxia and acidosis) which might affect the polymer endocytosis.Materials and methods: Six different N-(2-hydroxypropyl)methacrylamide (HPMA)-based polymer structures (homopolymer as well as…

Matthew Lipman e la Philosophy for Children come strategia educativa per combattere il fenomeno della violenza e della discriminazione sociale.

2021

With this contribution I want to highlight in what terms pedagogy can modify and revolutionize social relationships and significantly transform social communities. To do this, the Philosophy for Children conceived by Ann Sharp and Matthew Lipman will be taken as a reference point. Specifically, attention will be paid to the figure of Lipman, who will be examined from a historical point of view and with the aim of enhancing the motivation that led him, in the 1970s, to think of a pedagogy which, making use of of philosophy, stimulate and educate a critical and divergent thought, with which to protect, or determine from scratch, the essence of democracy. In this regard, the figure of Lipman w…

Chlorine as a Discriminant Element to Establish the Provenance of Central Mediterranean Obsidians

2020

Abstract Chlorine is a minor element present in obsidians in quantities greater than in average igneous rocks. The chlorine concentration in obsidians is generally low, of the order of tenths of wt %, but it exhibits an appreciable differentiation among geological sources. Despite these characteristics, chlorine has rarely been taken into consideration as a possible indicator of obsidian provenance and it does not appear in the chemical analytical tables accompanying the geochemical characterisation of obsidian samples. In this work, after an overview of chlorine geochemistry and cycle, we present thirty-one new electron microprobe (EPMA) analyses, including Cl, of geologic obsidians sample…

Effect of wetting/drying on the conformational arrangement of a heterogeneous organic mixture as assessed by solid state 13C NMR spectroscopy

2008

"Apmaiņa" : "Es, topošais pilsonis" mācību resursi

2023

Izdevums "Es, topošais pilsonis" ir metodisks līdzeklis ekonomikas, pilsoniskās izglītības un ētikas mācību satura apguvei starpdisciplinārā pieejā, kas izstrādāti Erasmus+ KA2 projekta I, Citizen to Be ietvaros. Projekta materiāli sastāv no 12 nodarbībām: personība, nabadzība, roboti, ekoloģija, patērētājs, brīvprātīgais darbs, sociālie tīkli, viltus ziņas, darbs, veselība, maiņa, uzņēmējdarbība. Katra nodarbība ir sagatavota tā, lai tā atbilstu skolēnu vecuma grupai, kā arī sociālajai un kognitīvajai attīstībai. Katrai nodarbībai tiek piedāvāts ieteicamais mācību procesa apraksts, kas ietver 3 vai vairāk fragmentus. Katrā nodarbībā tiek aktualizēta konkrēta tēma, kas atspoguļo personīgo v…