Search results for "PMA"
showing 10 items of 118 documents
Comparison of HapMap and 1000 genomes reference panels in a large-scale genome-wide association study
2017
An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we compared the results of GWA studies of circulating fibrinogen based on the two reference panels. Using both HapMap and 1000G imputation we performed a meta-analysis of 22 studies comprising the same 91,953 individuals. We identified six additional signals using 1000G imputation, while 29 loci were ass…
Pamatdatu pārvaldīšana lielapjoma datu sistēmās bāzētās Oracle Hyperion platformā
2017
Maģistra darba pētījumam ir izvēlēta kādas Zviedrijas bankas Hyperion Planning lietotne, kura tiek izmantota darījumu mērķu uzstādīšanai. Autores galvenais mērķis bija uzlabot bankas datu kvalitāti un pamatdatu pārvaldīšanas procesus, lai izvairītos no problēmām saistītām ar datu migrāciju starp lietotnēm, kļūdainām datu kalkulācijām un neprecīzām atskaitēm. Galvenais risinājums tika izstrādāts, izmantojot Oracle DRM pamatdatu pārvaldīšanas rīku, ar kura palīdzību pamatdatu apstrāde tika automatizēta, tādējādi samazinot cilvēciskā faktora risku. Rezultātā risinājums tika ieviests bankas sistēmā, kas tai deva ievērojamus uzlabojumus: tika nodrošināta papildus kvalitātes kontrole un versijpār…
Apoptosis rate of cumulus cells can be considered as an indicator for the selection of embryos to improve ongoing pregnancy and implantation rates.
2014
Cumulus cells apoptosis rate an adjunct to morphology evaluation for the embryo selection on day 3 could be considered a new tool, compared with embryo selection by morphology alone, to select the embryos with higher implantation potential to increase the clinical outcomes after ICSI. Several studies have demonstrated a lower cumulus cell apoptotic rates in women who achieved pregnancy compared with women who did not become pregnant after ICSI. A prospective randomized observational study on 76 ICSI patients was performed before Ovum Pick-Up. Patients were randomized into either the control group (embryo selection by morphology only, A group: 48 patients) or the treatment group (morphology …
P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellula…
2012
In order to explore the influence of polymer microstructure and stereochemistry in biological settings, the synthesis, micellization, cellular fate and the use in paclitaxel formulations of poly(N-(2-hydroxypropyl)-methacrylamide)-block-poly(L-lactide) (P(HPMA)-block-P(LLA)) and poly(N-(2-hydroxypropyl)-methacrylamide)-block-poly(DL-lactide) block copolymers (P(HPMA)-block-P(DLLA)) were studied. To this end, P(HPMA)-block-P(lactide) block copolymers and their fluorescently labeled analogues were synthesized. The polymers exhibited molecular weights M-n around 20,000 g/mol with dispersities (D=M-w/M-n) below 1.3. In addition, the solution conformation of this new type of partially degradable…
Stochastic ship roll motion via path integral method
2010
ABSTRACTThe response of ship roll oscillation under random ice impulsive loads modeled by Poisson arrival process is very important in studying the safety of ships navigation in cold regions. Under both external and parametric random excitations the evolution of the probability density function of roll motion is evaluated using the path integral (PI) approach. The PI method relies on the Chapman-Kolmogorov equation, which governs the response transition probability density functions at two close intervals of time. Once the response probability density function at an early close time is specified, its value at later close time can be evaluated. The PI method is first demonstrated via simple …
Couplings in coupled channels versus wave functions in the case of resonances: Application to the twoΛ(1405)states
2011
In this paper we develop a formalism to evaluate wave functions in momentum and coordinate space for the resonant states dynamically generated in a unitary coupled channel approach. The on-shell approach for the scattering matrix, commonly used, is also obtained in quantum mechanics with a separable potential, which allows one to write wave functions in a trivial way. We develop useful relationships among the couplings of the dynamically generated resonances to the different channels and the wave functions at the origin. The formalism provides an intuitive picture of the resonances in the coupled channel approach, as bound states of one bound channel, which decays into open ones. It also pr…
Doubly charmed exotic mesons: A gift of nature?
2011
Article history: We study doubly charmed exotic states by solving the scattering problem of two D mesons. Our results point to the existence of a stable isoscalar doubly charmed meson with quantum numbers (I) J P = (0)1 + . We perform a thorough comparison to the results obtained within the hyperspherical harmonic formalism. Such exotic states could be measured at LHC and RHIC. Their experimental observation would,
Study of meson production in nuclei near threshold
2009
We present a study of the η production at low energies in pd collision with 3He and pd nuclear systems in the final state. The η production mechanism is described by a two-step model and the final state interactions are included fully. The η - d and η - 3He final state interactions are incorporated through the solution of the Lippmann Schwinger equation for a half off-shell η - AT-matrix. For η - d this t -matrix is written in a factorized form, with an off-shell form factor multiplying an on-shell part having the scattering length representation. The p - d final state interaction is included by multiplying the production matrix element by the inverse of the Jost function which includes th…
Two pion decay of the Roper resonance
2002
We evaluate the two pion decay of the Roper resonance in a model where explicit re-scattering of the two final pions is accounted for by the use of unitarized chiral perturbation theory. Our model does not include an explicit $\epsilon$ or $\sigma$ scalar-isoscalar meson decay mode, instead it generates it dynamically by means of the pion re-scattering. The two ways, explicit or dynamically generated, of introducing this decay channel have very different amplitudes. Nevertheless, through interference with the other terms of the model we are able to reproduce the same phenomenology as models with explicit consideration of the $\epsilon$ meson.
Chiral symmetry amplitudes in the S-wave isoscalar and isovector channels and the σ, f[sub 0](980), a[sub 0](980) scalar mesons
1998
We use a nonperturbative approach which combines coupled channel Lippmann Schwinger equations with meson-meson potentials provided by the lowest order chiral Lagrangian. By means of one parameter, a cut off in the momentum of the loop integrals, which results of the order of 1 GeV, we obtain singularities in the S-wave amplitudes corresponding to the σ, f0 and a0 resonances. The ππ→ππ, ππ→KK phase shifts and inelasticities in the T=0 scalar channel are well reproduced as well as the π0η and KK mass distributions in the T=1 channel. Furthermore, the total and partial decay widths of the f0 and a0 resonances are properly reproduced. The results seem to indicate that chiral symmetry constraint…