Search results for "POINT"

Is time to joint replacement a valid outcome measure in clinical trials of drugs for osteoarthritis?

2003

The rate of radiographic joint space narrowing is commonly used today as a structural outcome measure in clinical trials evaluating potential disease-modifying drugs in patients with hip osteoarthritis, but this results in a continuous variable. Among the methods proposed to circumvent this problem, it has been suggested that the incidence of total hip arthoplasty (THA) provides a hard outcome measure. It is a dichotomized variable, easy to measure and sensitive to change, with acceptable intrinsic validity. However, because this measure is limited by the variability of factors underlying the decision to perform surgery and the length of waiting lists, it has been suggested that time to ful…

Communicating through ancillary gestures: Exploring effects on coperformers and audiences

2020

Musicians make elaborate movements while performing, often using gestures that might seem extraneous. To explore these movements, we motion-captured and audio-recorded different pairings of clarinetists and pianists performing Brahms’ Clarinet Sonata No. 1 with two manipulations: (a) allowing the performers full vs. no visual feedback, and (b) allowing the performers full vs. partial auditory feedback (i.e., the clarinetist could not hear the pianist). We found that observer ratings of audio–visual point-light renditions discriminated between manipulations and refined this insight through subsequent audio-alone and visual-alone experiments, providing an understanding of each modality’s cont…

Open-label ODYSSEY APPRISE study: Interim data from the first 843 participants

2018

Background PCSK9 inhibitors (PCSK9i) have been recommended by the ESC/EAS Task Force in very high risk subjects with ASCVD and those with heterozygous familial hypercholesterolemia (HeFH) with persistent high LDL-C levels despite maximally tolerated LLT. Purpose ODYSSEY APPRISE (NCT02476006) is the first study to assess efficacy and safety at Week (W) 12 of the PCSK9i alirocumab (ALI) in a real-life setting prior to commercial availability. Methods APPRISE was an open-label, single-arm study, conducted in 16 European countries and Canada. Subjects with inadequately controlled lipid levels despite maximally tolerated LLT were included. Based on physician's judgment, participants received eit…

Blends of Semiflexible Polymers: Interplay of Nematic Order and Phase Separation

2021

Mixtures of semiflexible polymers with a mismatch in either their persistence lengths or their contour lengths are studied by Density Functional Theory and Molecular Dynamics simulation. Considering lyotropic solutions under good solvent conditions, the mole fraction and pressure is systematically varied for several cases of bending stiffness κ (the normalized persistence length) and chain length N. For binary mixtures with different chain length (i.e., NA=16, NB=32 or 64) but the same stiffness, isotropic-nematic phase coexistence is studied. For mixtures with the same chain length (N=32) and large stiffness disparity (κB/κA=4.9 to 8), both isotropic-nematic and nematic-nematic unmixing oc…

Evaluation of Innovation Statistics Data Quality Dimensions.

2017

Promocijas darbā analizēta praktiskā situācija statistikas par inovācijām vākšanas un apstrādes procesā Latvijā, tiek apskatīta statistikas par inovācijām metodoloģija un tās pielietošanas prakse Latvijā, īpašu uzmanību pievēršot Latvijas inovāciju sistēmas īpatnībām. Pētījumā izstrādātās Latvijas inovāciju vadības un informācijas plūsmas sistēmas ietvaros tiek pamatots informatīvā atbalsta nozīmīgums lēmumu pieņemšanā. Balstoties uz Datu kvalitātes dimensiju novērtēšanas metodiku, veikts inovāciju statistikas datu kvalitātes novērtējums Latvijā. Ir izstrādāta un aprobēta Iteratīvā metode neraksturīgo punktu ietekmes mazināšanai. Pētījuma ietvaros tiek aplūkoti statistikas par inovācijām kv…

Sensitivity analysis in investment project of biogas plant

2017

The article shows the practical value of biogas as the second generation biofuel. All the projects dealing with biogas are subjected to external risks, such as the change of market condition, customer needs, governmental regulation, etc. In conditions of uncertainty it is necessary for administration to concentrate on decisionmaking. Fluctuations of sales volume, energy resources and raw material prices, etc. should be taken into account. Sensitivity analysis can predict the result of negative external pheno mena. We developed the economic-mathematical model for the analysis of biogas complexes sensitivity. The profitability index as a criterion for the effectiveness of investment projects …

Community detection of seismic point processes

2022

In this paper, we combine robin and Local Indicators of Spatio-Temporal Association (LISTA) functions. robin is an R package to assess the robustness of the community structure of a network found by one or more methods to give indications about their reliability. We use it to propose a classification algorithm of events in a spatio-temporal point pattern, by means of the local second-order characteristics and the community detection procedure in network analysis. We demonstrate the proposed procedure on a real data analysis on seismic data.

Detector-based visual analysis of time-series data

2015

GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral

2017

On August 17, 2017 at 12-41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×104 years. We infer the component masses of the binary to be between 0.86 and 2.26 M, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M, with the total mass of the system 2.74-0.01+0.04M. The source was localized within a sky region of 28 deg2 (90% probabili…

Smoothed score confidence interval for the breakpoint in segmented regression

2012

For the breakpoint parameter in segmented regression we consider confidence intervals based on the score statistic. Due to unsmoothness of the score, we propose to build the confidence intervals using its smoothed version under proper shape restrictions. Some simulations are presented to assess the finite sample performance of the proposed approach.