Search results for "POLE"

Pharmacogenomics of Scopoletin in Tumor Cells

2016

Drug resistance and the severe side effects of chemotherapy necessitate the development of novel anticancer drugs. Natural products are a valuable source for drug development. Scopoletin is a coumarin compound, which can be found in several Artemisia species and other plant genera. Microarray-based RNA expression profiling of the NCI cell line panel showed that cellular response of scopoletin did not correlate to the expression of ATP-binding cassette (ABC) transporters as classical drug resistance mechanisms (ABCB1, ABCB5, ABCC1, ABCG2). This was also true for the expression of the oncogene EGFR and the mutational status of the tumor suppressor gene, TP53. However, mutations in the RAS onc…

The activity of Artemisia spp. and their constituents against Trypanosomiasis.

2018

Abstract Background Trypanosomiasis belongs to the neglected tropical diseases. Although standard therapies are available, the safety and efficacy of current synthetic drugs are limited due to the development of drug resistance and adverse side effects. Purpose Artemisia annua and artemisinin are not only active against Plasmodia, but also other protozoa. Therefore, we reviewed the literature on species of the genus Artemisia and their phytochemicals regarding their activity against trypanosomes. Study design A PubMed search for “Artemisia/Artemisinin and Trypanosoma” has been conducted for literature until December 2017. Results Interestingly, not only A. annua L. and its active principle,…

Noninvasive ventilation for acute hypoxemic respiratory failure/ARDS: The show must go on

2018

Rho resonance, timelike pion form factor, and implications for lattice studies of the hadronic vacuum polarization

2020

We study isospin-1 P-wave ππ scattering in lattice QCD with two flavors of O(a) improved Wilson fermions. For pion masses ranging from mπ=265 MeV to mπ=437 MeV, we determine the energy spectrum in the center-of-mass frame and in three moving frames. We obtain the scattering phase shifts using Lüscher’s finite-volume quantization condition. Fitting the dependence of the phase shifts on the scattering momentum to a Breit-Wigner form allows us to determine the corresponding ρ mass mρ and gρππ coupling. By combining the scattering phase shifts with the decay matrix element of the vector current, we calculate the timelike pion form factor, Fπ, and compare the results to the Gounaris-Sakurai repr…

The synthesis of fluorinated heteroaromatic compounds. Part 1. Five-membered rings with more than two heteroatoms. A review

2005

(2005). THE SYNTHESIS OF FLUORINATED HETEROAROMATIC COMPOUNDS. PART 1. FIVE-MEMBERED RINGS WITH MORE THAN TWO HETEROATOMS. A REVIEW. Organic Preparations and Procedures International: Vol. 37, No. 5, pp. 447-506.

Effective and environmental half-lives of radiocesium in game from Poland.

2021

For the first time changes in the 137Cs activity in game throughout Poland, including its most contaminated part known as the Opole Anomaly, were analyzed. Due to its long physical half-life, 137Cs continuously demonstrates high activity both in soil and biota. The species of game mammals, along with forest fruit and mushrooms, tend to accumulate this radionuclide, becoming one of the main sources of secondary contamination in people. In this study the 137Cs activity in roe deer, wild boar and red deer muscle tissue samples, within the years of 1986–2019, were studied. The effective and environmental half-lives were determined for each of the mentioned species for four regions including NE …

Surface charges at the CaF2/water interface allow very fast intermolecular vibrational-energy transfer

2020

Abstract We investigate the dynamics of water in contact with solid calcium fluoride, where at low pH, localized charges can develop upon fluorite dissolution. We use 2D surface‐specific vibrational spectroscopy to quantify the heterogeneity of the interfacial water (D2O) molecules and provide information about the sub‐picosecond vibrational‐energy‐relaxation dynamics at the buried solid/liquid interface. We find that strongly H‐bonded OD groups, with a vibrational frequency below 2500 cm−1, display very rapid spectral diffusion and vibrational relaxation; for weakly H‐bonded OD groups, above 2500 cm−1, the dynamics slows down substantially. Atomistic simulations based on electronic‐structu…

Low-lying electric dipole gamma-continuum for the unstable Fe-62,64 nuclei : Strength evolution with neutron number

2020

6 pags., 4 figs.

Lo civil en el Código napoleónico y la libertad de los modernos

2020

RESUMEN:El propósito de este artículo es explicar el cambio de significado que lo civil sufre en el Código napoleónico. Me centro, a tal efecto, en el discurso preliminar pronunciado por Portalis en la presentación del proyecto de 1801, y comparo su concepción con la de Montesquieu. Para este último, las leyes civiles son aquellas que regulan las relaciones de los ciudadanos entre sí, a fin de garantizar el mantenimiento y la unidad de la comunidad política. Portalis pretende, en cambio, que esta misma función de cemento cívico la desempeñe un Código civil que se ocupa únicamente de esa esfera privada en la que los individuos disfrutan de su propiedad. Como muestro en la conclusión, Benjami…

A theoretical study of the 1B2u and 1B1u vibronic bands in benzene

2000

The two lowest bands, 1B2u and 1B1u, of the electronic spectrum of the benzene molecule have been studied theoretically using a new method to compute vibronic excitation energies and intensities. The complete active space (CAS) self-contained field (SCF) method (with six active π-orbitals) was used to compute harmonic force field for the ground state and the 1B2u and 1B1u electronic states. A linear approximation has been used for the transition dipole as a function of the nuclear displacement coordinates. Derivatives of the transition dipole were computed using a variant of the CASSCF state interaction method. Multiconfigurational second-order perturbation theory (CASPT2) was used to obtai…