Search results for "PPA"
showing 10 items of 2858 documents
Eurooppa ja identiteetit liikkeessä
2017
Non peer reviewed
Europe from Below : Notions of Europe and the European among Participants in EU Cultural Initiatives
2021
In this book, Tuuli Lähdesmäki, Katja Mäkinen, Viktorija L. A. Čeginskas, and Sigrid Kaasik-Krogerus scrutinize how people who participate in cultural initiatives funded and governed by the European Union understand the idea of Europe. The book focuses on three cultural initiatives: the European Capital of Culture, the European Heritage Label, and a European Citizen Campus project funded through the Creative Europe programme. These initiatives are examined through field studies conducted in 12 countries between 2010 and 2018. The authors describe their approach as ‘ethnography of Europeanization’ and conceptualize the attempts at Europeanization in the European Union’s cultural policy as po…
Las familias reconstituidas. Una realidad en continuo crecimiento
2020
Cada vez más parejas que han contraído matrimonio o formalizado su unión se disuelven y vuelven a formar otras familias, las llamadas familias reconstituidas. En ellas se involucran adultos y menores, por lo que necesitan una identidad propia que determine los derechos y obligaciones de cada uno. Aunque nada se ha previsto en el Código civil español, no acontece igual en otros Derechos, como en algunos de los llamados Derechos forales y en los ordenamientos jurídicos de otros países. Partiendo de ello, en este artículo vamos a realizar algunas consideraciones en torno a lo que podría ser su régimen jurídico. More and more couples who have married or formalized their union are dissolving and…
Religious-Philosophical Articles, XXXIII
2022
Žurnāla “Reliģiski-filozofiski raksti” XXXIII laidiens veltīts Latvijas sabiedrības vērtību analīzei salīdzinošā perspektīvā. Ņemot vērā vērtību jēdziena daudzdimensionālo raksturu, vērtību apraksts, analīze un klasifikācija visos laikos ir izraisījusi diskusijas, strīdus un pat konfliktus. Ideja veidot speciālu žurnāla numuru nolūkā veicināt teorētisko un empīrisko zināšanu attīstību par vērtībām Latvijā, aicinot sociālo un humanitāro zinātņu pētniekus dalīties ar jaunākajiem pētījumiem un atziņām šajā jomā, dzima projekta “Vērtību maiņa nestabilos apstākļos: sabiedrības saliedētība un neoliberālais ētoss” īstenošanas laikā. Pētnieciskā projekta tiešais mērķis bija sniegt jaunu salīdzinošu…
Sicilian Populations of Capparis spinosa L. and Capparis orientalis Duhamel as Source of the Bioactive Flavonol Quercetin
2023
The genus Capparis is a taxon of difficult delimitation that has several species and ecotypes due to its wide heterogeneity, its extreme phenotypic diversity, and the presence of intermediate forms linked to hybridization phenomena. The Sicilian territory hosts numerous wild and cultivated populations of two spp. Capparis spinosa L. and Capparis orientalis Duhamel, which are ecologically and morphologically distinct. The caper has considerable interest and economic value for its medicinal properties, culinary uses, and cultivation characteristics. It is one of the foods with the highest quercetin content. Quercetin is a flavonol with antioxidant, anti-inflammatory, and immunostimulant prope…
Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell
2019
Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to inhibit the growth of different tumor cell types. Essential oils contain several chemical classes of compounds whose heterogeneity of active moieties can help prevent the development of drug resistance. In the present paper, we analyzed, by gas chromatography-mass spectrometry the chemical composition of the essential oil of the leaves of Kalanchoe beharensis obtained by hydrodistillation and compared the chemical composition of its essential oil with that of Cyphostemma juttae.…
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
OTTIMIZZAZIONE DELLE PRESTAZIONE DEL SISTEMA DEI TRASPORTI TRAMITE L’ARMONIZZAZIONE INTERNAZIONALE DEGLI APPARATI DI SEGNALAZIONE
2012
Cabbage and fermented vegetables: from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
2021
International audience; Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1 R) axis associated with oxidative stress. This leads to insulin resistance …
Asem ja uusi kansainvälinen järjestys : Euroopan ja Aasian yhteistyön vaikutus valtioiden suvereniteettiin
2010
Tutkimus tarkastelee Euroopan ja Aasian maiden yhteistyötä Asem-prosessin puitteissa. Asem-prosessi on monien hallintoviranomaisten kokousten kokonaisuus, jonka tärkeimmät päätökset tehdään kahden vuoden välein järjestettävissä hallitusten päämiesten huippukokouksissa. Tutkimuksen tarkoitus on selvittää, kuinka paitsi maanosien sisäinen integraatio, myös niiden välinen yhteistyö vaikuttavat osallistujavaltioiden suvereniteettiin. Tutkimuksen aineiston muodostaa Asem-huippukokousten yhteydessä julkaistut puheenjohtajan lausunnot ja huippukokouksissa julkaistut poliittiset ja temaattiset julistukset. EU:n ja Aseanin toiminnan kuvaamisessa olen lisäksi käyttänyt lähteinä näiden organisaatioide…