Search results for "PPARa"
showing 10 items of 1343 documents
Performance of PSI, CURB-65, and SCAP scores in predicting the outcome of patients with community-acquired and healthcare-associated pneumonia
2011
The objective was to compare three score systems, pneumonia severity index (PSI), the Confusion-Urea-Respiratory Rate-Blood pressure-65 (CURB-65), and severe community-acquired pneumonia (SCAP), for prediction of the outcomes in a cohort of patients with community-acquired (CAP) and healthcare-associated pneumonia (HCAP). Large multi-center, prospective, observational study was conducted in 55 hospitals. HCAP patients were included in the high classes of CURB-65, PSI and SCAP scores have a mortality rate higher than that of CAP patients. HCAP patients included in the low class of the three severity rules have a significantly higher incidence of adverse events, including development of septi…
A Model for ERD2 Function in Higher Plants
2020
ER lumenal proteins have a K(H)DEL motif at their C-terminus. This is recognized by the ERD2 receptor (KDEL receptor in animals), which localizes to the Golgi apparatus and serves to capture escaped ER lumenal proteins. ERD2-ligand complexes are then transported back to the ER via COPI coated vesicles. The neutral pH of the ER causes the ligands to dissociate with the receptor being returned to the Golgi. According to this generally accepted scenario, ERD2 cycles between the ER and the Golgi, although it has been found to have a predominant Golgi localization. In this short article, we present a model for the functioning of ERD2 receptors in higher plants that explains why it is difficult t…
Loss of Arabidopsis p24 function affects ERD2 traffic and Golgi structure and activates the unfolded protein response
2017
The p24 family of proteins (also known as the TMED family) are key regulators of protein trafficking along the secretory pathway, but very little is known about their functions in plants. A quadruple loss-of-function mutant affecting the p24 genes from the δ-1 subclass of the p24δ subfamily (p24δ3δ4δ5δ6) showed alterations in the Golgi, suggesting that these p24 proteins play a role in the organization of the compartments of the early secretory pathway in Arabidopsis Loss of p24δ-1 proteins also induced the accumulation of the K/HDEL receptor ERD2a (ER lumen protein-retaining receptor A) at the Golgi and increased secretion of BiP family proteins, ER chaperones containing an HDEL signal, pr…
Loss of
2020
The early secretory pathway involves bidirectional transport between the endoplasmic reticulum (ER) and the Golgi apparatus and is mediated by coat protein complex I (COPI)-coated and coat protein complex II (COPII)-coated vesicles. COPII vesicles are involved in ER to Golgi transport meanwhile COPI vesicles mediate intra-Golgi transport and retrograde transport from the Golgi apparatus to the ER. The key component of COPI vesicles is the coatomer complex, that is composed of seven subunits (α/β/β'/γ/δ/ε/ζ). In Arabidopsis two genes coding for the β-COP subunit have been identified, which are the result of recent tandem duplication. Here we have used a loss-of-function approach to study the…
ß-COP mutants show specific high sensitivity to chloride ions.
2021
Coat Protein I (COPI) consists of a complex (coatomer) formed by seven subunits (α-, β-, β’-, γ-, δ-, ε-, and ζ-COP) that is recruited to Golgi membranes to form vesicles that shuttle from the Golgi apparatus to the ER and between Golgi stacks. Recently, it has been described that loss of function mutants of the two Arabidopsis β-COP genes, β1-COP and β2-COP, showed increased sensitivity to salt stress (NaCl). Using a mixture of either Na(+) or Cl(−) salts, we have now found that β-COP mutants are specifically and highly sensitive to chloride ions.
Studies on the genusCapparisL. (Capparaceae) in Lao PDR
2016
Southeastern Asia is one of the main centres of diversity of the genus Capparis in the Old World. Morpho-chorological investigations carried out on collections from Lao PDR provided new data on the variation and distribution of some intrageneric taxa that were critical, poorly known or unrecorded in the country. The variability of Capparis pyrifolia and Capparis zeylanica is discussed, while Capparis acutifolia subsp. acutifolia and Capparis tenera are respectively confirmed and first recorded in Lao PDR. A new variety of Capparis micracantha is described and 12 lectotypes are designated. For each taxon morphological, chorological and autecological data are given.
Studies on the genus Capparis L. (Capparaceae) in Lao PDR. V: A new species from limestones of the Luang Prabang Province
2020
A new species of Capparis L., C. lianosa Fici & Souvannakhoummane, is described and illustrated from limestones of the Muang Ngoi District, Luang Prabang Province, in northern Lao PDR. Th e new species, belonging to Capparis sect. Monostichocalyx Radlk., is related to C. zeylanica L., differing in several characters as the shorter stipular thorns, the leaves with apex acuminate, the shorter, glabrous or glabrescent gynophore and the flattened stigma.
A new species of Capparis (Capparaceae) from ultramafic substrata in New Caledonia
2017
A new species of Capparis, C. parvifolia, is described and illustrated from New Caledonia, where it is known from a few localities on Mont Kaala on ultramafic substrata. The new species is characterized by the relatively small, linear leaf-blade and by the small size of the sepals, petals, stamens, gynophore and fruit. Its affinities with related taxa are discussed and its conservation status assessed.
A taxonomic revision of the genus Capparis (Capparaceae) in New Caledonia
2017
A revision of the genus Capparis has been carried out in New Caledonia, a global biodiversity hotspot with a high rate of endemism in its vascular flora. The taxonomic treatment of Capparis in this area required study because of some incompletely known taxa and deviating forms. Based on morphological and distributional investigations carried out on historical and recent herbarium collections, four species are recognised in New Caledonia: C. spinosa, belonging to sect. Capparis; C. quiniflora, belonging to sect. Monostychocalix; and C. parvifolia and C. artensis, both belonging to sect. Busbeckea. Capparis spinosa is represented by subsp. cordifolia, a taxon widespread in several Pacific isl…
Studies on the genus Capparis L. (Capparaceae) in Lao PDR. III: A new species from the deciduous forest of the Hin Nam No National Protected Area
2018
A new species of Capparis, Capparis hinnamnoensis, is described from the Khammouan Province, central Lao PDR. The new species is characterized by the indumentum constituted by stellate, two-armed and simple hairs, and by the terminal racemes bearing trifid bracts and mediumsized flowers. It is so far known from a single locality in the Hin Nam No National Protected Area, where it has been observed in the deciduous forest on Permo-Carboniferous limestone. Its conservation status is assessed.