Search results for "PPI"
showing 10 items of 7396 documents
«Povera, buona, malinconica Italia». Le cartografie di Orio Vergani
2019
Un'intensa urgenza di ricostruzione si ritrova nelle pagine di Orio Vergani dedicate alle imprese ciclistiche di Fausto Coppi, in cui la cronaca sportiva si fonde al racconto del tormentato ventennio che va dal 29 maggio del 1940 sino alla morte del «campionissimo», nel gennaio del 1960. In tale ‘narrazione’, che coopera a delineare un percorso ideologico e politico di adesione al fascismo mai negato dallo scrittore ma vissuto, soprattutto a ridosso della guerra, in modo problematico, il trattamento dello spazio riveste una centralità conoscitiva ed intepretativa fondante, configurando topografie in cui spaccato documentario, analisi societaria, suggestione narrativa coesistono. Nell’immedi…
Karšu zinātne, 2 daļas
1948
Teksts mašīnrakstā
Heterozygote Advantage Probably Maintains Rhesus Factor Blood Group Polymorphism: Ecological Regression Study
2016
Rhesus factor polymorphism has been an evolutionary enigma since its discovery in 1939. Carriers of the rarer allele should be eliminated by selection against Rhesus positive children born to Rhesus negative mothers. Here I used an ecologic regression study to test the hypothesis that Rhesus factor polymorphism is stabilized by heterozygote advantage. The study was performed in 65 countries for which the frequencies of RhD phenotypes and specific disease burden data were available. I performed multiple multivariate covariance analysis with five potential confounding variables: GDP, latitude (distance from the equator), humidity, medical care expenditure per capita and frequencies of smokers…
SUSTAINABLE AGRICULTURE MANAGEMENTS TO CONTROL SOIL EROSION
2021
[EN] High rates of soil erosion compromise sustainable agriculture. In rainfed agricultural fields, erosion rates several orders of magnitude higher than the erosion rates considered tolerable have been quantified. In Mediterranean rainfed crops such as vineyards, almonds and olive groves, and in the new sloping citrus and persimmon plantations, the rates of soil loss make it necessary to apply measures to reduce them to avoid collapse in agricultural production. Managements such as weeds, catch crops and mulches (straw and pruning remains) are viable options to achieve sustainability. This work applies measurements through plots, simulated rainfall experiments and ISUM (Improved Stock-Unea…
Suomi toisena kielenä -oppijoiden sanaston kehittyminen taitotasolta toiselle siirryttäessä
2012
Tutkimuksen tavoitteena on selvittää, kuinka sanaston käyttö kehittyy suomi toisena kielenä -oppijoiden teksteissä. Tarkastelun kohteena on sanavaraston rikkaus eli leksikaalinen diversiteetti. Aineistona on 1197 aikuisten ja koululaisten eri tekstilajeja edustavaa kirjoitusta, jotka on arvioitu valmiiksi Eurooppalaisen viitekehyksen mukaisille taitotasoille. Työ on osa Suomen Akatemian ja Jyväskylän yliopiston vuosina 2007-2009 rahoittamaa Cefling hanketta, jonka tehtävänä on selvittää, millaista kielitaito on kullakin Eurooppalaisessa viitekehyksessä kuvatulla kuudella taitotasolla. Tavoitteena on myös selvittää, onko aikuisten ja koululaisten kielenoppimisessa eroja. Keskeisimmät teoreet…
Comparative analysis of virtual screening approaches in the search for novel EphA2 receptor antagonists
2015
The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many cancer types and involved in tumor growth. Recent medicinal chemistry efforts have identified bile acid derivatives as low micromolar binders of the EphA2 receptor. However, these compounds suffer from poor physicochemical properties, hampering their use in vivo. The identification of compounds able to disrupt the EphA2-ephrin-A1 complex lacking the bile acid scaffold may lead to new pharmacological tools suitable for in vivo studies. To identify the most promising virtual screening (VS) protocol aimed at finding novel EphA2 antagonists, we investigated the ability of…
The effect of cadmium on brain cells in culture
2009
Cadmium is a long-living heavy metal, abundantly present in the environment, which accumulates in the body. In this study, we investigated the effects of cadmium on the expression of molecular chaperones, and of certain cell-specific proteins, in a variety of brain cell types in culture, namely primary cultures of rat cortical neurons and astrocytes, a brain capillary endothelial cell line (RB4E.B cells), and pheochromocytoma cells (PC12), induced or not to differentiate by NGF treatment. The metal induces a dose-dependent increase of Hsp70 in all cell types. Responses to the metal are cell-specific in the case of Hsc70 and Hsp90: i) in astrocytes, as well as in PC12 cells, cadmium has no s…
Hot air stream reduces cytotoxicity of light-cured calcium hydroxide based cements
2019
Background The light-cured calcium hydroxide based cements have incomplete polymerization and unconverted monomers can cause pulp cell damage. The aim of this study was to evaluate the influence of a warm and hot air stream on the cytotoxicity of light-cured calcium hydroxide based cements. Material and methods The materials Dycal (conventional cement), Biocal, Hidrox-Cal, and Ultra-Blend Plus (light-cured calcium hydroxide cements) were submitted to cytotoxicity analysis after polymerization, without vs. with previous heat treatment with a warm (37°C) and a hot (60°C) air stream. Following polymerization, cements were maintained in culture medium for 24 hours and 7 days, and subjected to t…
Analysis of Drosophila salivary gland, epidermis and CNS development suggests an additional function of brinker in anterior-posterior cell fate speci…
2000
Salivary glands are simple structured organs which can serve as a model system in the study of organogenesis. Following a large EMS mutagenesis we have identified a number of genes required for normal salivary gland development. Mutations in the locus small salivary glands-1 (ssg-1) lead to a drastic reduction in the size of the salivary glands. The gene ssg-1 was cloned and subsequent sequence and genetic analysis showed identity to the recently published gene brinker. The salivary gland placode in brinker mutants appears reduced along both the anterior-posterior and dorso-ventral axis. Analysis of the brinker cuticle phenotype revealed a similar loss of anterior-posterior as well as later…
The Relationship between Gray Matter Quantitative MRI and Disability in Secondary Progressive Multiple Sclerosis
2016
Purpose: In secondary progressive Multiple Sclerosis (SPMS), global neurodegeneration as a driver of disability gains importance in comparison to focal inflammatory processes. However, clinical MRI does not visualize changes of tissue composition outside MS lesions. This quantitative MRI (qMRI) study investigated cortical and deep gray matter (GM) proton density (PD) values and T1 relaxation times to explore their potential to assess neuronal damage and its relationship to clinical disability in SPMS. Materials and Methods: 11 SPMS patients underwent quantitative T1 and PD mapping. Parameter values across the cerebral cortex and deep GM structures were compared with 11 healthy controls, and…