Search results for "PPI"
showing 10 items of 7396 documents
Concurrent Changes of Brain Functional Connectivity and Motor Variability When Adapting to Task Constraints
2018
In behavioral neuroscience, the adaptability of humans facing different constraints has been addressed on one side at the brain level, where a variety of functional networks dynamically support the same performance, and on the other side at the behavioral level, where fractal properties in sensorimotor variables have been considered as a hallmark of adaptability. To bridge the gap between the two levels of observation, we have jointly investigated the changes of network connectivity in the sensorimotor cortex assessed by modularity analysis and the properties of motor variability assessed by multifractal analysis during a prolonged tapping task. Four groups of participants had to produce th…
Dynamic 3D Scene Reconstruction and Enhancement
2017
International audience; In this paper, we present a 3D reconstruction and enhancement approach for high quality dynamic city scene reconstructions. We first detect and segment the moving objects using 3D Motion Segmenta-tion approach by exploiting the feature trajectories' behaviours. Getting the segmentations of both the dynamic scene parts and the static scene parts, we propose an efficient point cloud registration approach which takes the advantages of 3-point RANSAC and Iterative Closest Points algorithms to produce precise point cloud alignment. Furthermore, we proposed a point cloud smoothing and texture mapping framework to enhance the results of reconstructions for both the static a…
Reliability of Virtual Screening Methods in Prediction of PDE4Binhibitor Activity
2015
Identification of active ligands using computational methods is a challenging task. For example, molecular docking, pharmacophore modeling, and three dimensional quantitative structure-activity relationship models (3D-QSAR) are widely used methods to identify novel small molecules. However, all these methods have, in addition to advantages, also significant pitfalls. The aim of this study was to compare some commonly used computational methods to estimate their ability to separate highly active PDE4B-inhibitors from less active and inactive ones. Here, 152 molecules with pIC 50 -range of 3.4-10.5, originating from six original studies were used. High correlation coefficients by using dockin…
Atrial activity extraction for atrial fibrillation analysis using blind source separation.
2004
This contribution addresses the extraction of atrial activity (AA) from real electrocardiogram (ECG) recordings of atrial fibrillation (AF). We show the appropriateness of independent component analysis (ICA) to tackle this biomedical challenge when regarded as a blind source separation (BSS) problem. ICA is a statistical tool able to reconstruct the unobservable independent sources of bioelectric activity which generate, through instantaneous linear mixing, a measurable set of signals. The three key hypothesis that make ICA applicable in the present scenario are discussed and validated: 1) AA and ventricular activity (VA) are generated by sources of independent bioelectric activity; 2) AA …
Mediated learning materials: visibility checks in telepresence robot mediated classroom interaction
2021
Videoconferencing is increasingly used in education as a way to support distance learning. This article contributes to the emerging interactional literature on video-mediated educational interaction by exploring how a telepresence robot is used to facilitate remote participation in university-level foreign language teaching. A telepresence robot differs from commonly used videoconferencing set-ups in that it allows mobility and remote camera control. A remote student can thus move a classroom-based robot from a distance in order to shift attention between people, objects and environmental structures during classroom activities. Using multimodal conversation analysis, we focus on how partici…
Identification of Reading Difficulties by a Digital Game-Based Assessment Technology
2020
Computerized game-based assessment (GBA) system for screening reading difficulties may provide substantial time and cost benefits over traditional paper-and-pencil assessment while providing means also to individually adapt learning content in educational games. To study the reliability and validity of a GBA system to identify struggling readers performing below a standard deviation from mean in paper-and-pencil test either in raw scores and grade-normative scores, a large-scale study with first to fourth grade students ( N = 723) was conducted, where GBA was administrated as a group test by tablet devices. Overall, the results indicated that the GBA can be successfully used to identify st…
An evolutionary restricted neighborhood search clustering approach for PPI networks
2014
Protein-protein interaction networks have been broadly studied in the last few years, in order to understand the behavior of proteins inside the cell. Proteins interacting with each other often share common biological functions or they participate in the same biological process. Thus, discovering protein complexes made of a group of proteins strictly related can be useful to predict protein functions. Clustering techniques have been widely employed to detect significant biological complexes. In this paper, we integrate one of the most popular network clustering techniques, namely the Restricted Neighborhood Search Clustering (RNSC), with evolutionary computation. The two cost functions intr…
Automatic Image Annotation Using Random Projection in a Conceptual Space Induced from Data
2018
The main drawback of a detailed representation of visual content, whatever is its origin, is that significant features are very high dimensional. To keep the problem tractable while preserving the semantic content, a dimen- sionality reduction of the data is needed. We propose the Random Projection techniques to reduce the dimensionality. Even though this technique is sub-optimal with respect to Singular Value Decomposition its much lower computational cost make it more suitable for this problem and in par- ticular when computational resources are limited such as in mobile terminals. In this paper we present the use of a "conceptual" space, automatically induced from data, to perform automa…
An Unsupervised Method for Suspicious Regions Detection in Mammogram Images
2015
Over the past years many researchers proposed biomedical imaging methods for computer-aided detection and classification of suspicious regions in mammograms. Mammogram interpretation is performed by radiologists by visual inspection. The large volume of mammograms to be analyzed makes such readings labour intensive and often inaccurate. For this purpose, in this paper we propose a new unsupervised method to automatically detect suspicious regions in mammogram images. The method consists mainly of two steps: preprocessing; feature extraction and selection. Preprocessing steps allow to separate background region from the breast profile region. In greater detail, gray levels mapping transform …
Grammar is the heart of language : grammar and its role in language learning among Finnish university students
2015
This article presents and discusses views on grammar and its role in formal language learning amongst Finnish university students. The results are based on a questionnaire which was distributed to students at the University of Jyväskylä as part of institutional action research. The background to the project was a feeling amongst some teachers of increased divergence between student respectively language teacher understandings of the role of grammar in language teaching. This concern raised the need to find out how students view grammar. The knowledge about thoughts on grammar amongst students would then help teachers to adjust and adept the way grammar is used in language teaching. The main…