Search results for "PPI"
showing 10 items of 7396 documents
An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.
2021
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system to classify the basic operational modes of neurons and circuits. Single-cell phenotyping of firing behavior during ongoing oscillations in vivo has provided a large body of evidence on entorhinal–hippocampal function, but data are dispersed and diverse. Here, we mined literature to search for information regarding the phase-timing dynamics of over 100 hippocampal/entorhinal neuron types defined in Hippocampome.org. We identified missing and unresolved pieces of knowledge (e.g., the preferred theta phase for a specific neuron type) a…
Effects of environment and genotype on dispersal differ across departure, transfer and settlement in a butterfly metapopulation
2022
Active dispersal is driven by extrinsic and intrinsic factors at the three stages of departure, transfer and settlement. Most empirical studies capture only one stage of this complex process, and knowledge of how much can be generalized from one stage to another remains unknown. Here we use genetic assignment tests to reconstruct dispersal across 5 years and 232 habitat patches of a Glanville fritillary butterfly ( Melitaea cinxia ) metapopulation. We link individual dispersal events to weather, landscape structure, size and quality of habitat patches, and individual genotype to identify the factors that influence the three stages of dispersal and post-settlement survival. We found that ne…
Laulava ja liikkuva lapsi : toiminnallisen laulunopetuksen materiaalipaketti alakouluun
2015
Lapselle liike on luontaisin tapa ilmentää musiikkia. Myös laulaminen ja oman äänen käyttö on läsnä lapsen elämässä pienestä pitäen. Koulun musiikintunnilla voisi hyödyntää lapsen luontaista intoa liikkua ja laulaa ja perustaa opetus niille. Tutkimukseni tarkoituksena on luoda toiminnallinen laulunopetuksen materiaalipaketti alakouluun ja testata sitä. Materiaalipakettini perustuu valtakunnallisen perusopetuksen opetussuunnitelman (2014) laulunopetuksen tavotteisiin ja sisältöihin ja uusimpiin musiikin oppimateriaaleihin. Lisäksi olen lisännyt materiaaliin omia ideoitani ja vinkkejäni laulunopetuksesta alakoulussa. Tutkimuksessani punaisena lankana kulkee sana ”toiminnallisuus”, jonka koen …
Teachers as frontline agents of integration: Finnish physical education students’ reflections on intercultural encounters
2018
Background and purpose: This article focuses on how future Physical Education and Dance teachers may be better prepared to work in increasingly diverse education environments. It also discusses how tertiary institutions might address issues of social inclusion and cultural pluralism within their programmes, courses and assignments. The authors critically reflect on an experiential learning intervention in Jyväskylä, Finland, in which trainee PE teachers facilitated kinaesthetic language-learning workshops for asylum seekers. The applied use of physical education and dance in this context was aimed at providing a distinct opportunity to consider a PE teacher’s professional competence and rol…
Tourism in the European economic crisis: Mediatised worldmaking and new tourist imaginaries in Greece
2016
The article interrogates the rationale and origins of changing imaginaries of tourism in Greece in the context of the current economic crisis. We detect a radical change in the ‘picture’ of the country that circulates in global media conduits (YouTube, Facebook, official press websites and personal blogs). We enact a journey into past media representations of Greece as an idyllic peasant and working-class site, but proceed to highlight that such representations are being recycled today by Greeks (especially but not exclusively) living and studying abroad. This stereotype, which focuses on embodied understandings of happiness and well-being, is being challenged by the current economic crisi…
Agency and Learning in the Work of Software Professionals
2017
This chapter addresses software professionals’ agency and learning in work characterized by a need for innovative learning and fluency in renewing work practices. The study presented was conducted with software professionals in a medium-sized Finnish company producing digital business applications. We applied a mixed-method approach to data collection and analysis. Regarding professional agency, we found a range of opportunities to influence work-related matters. The professionals were primarily able to influence their working hours and the order of their work tasks, but had fewer opportunities to influence customer projects, or their salary. To some extent they were able to develop themsel…
Industrial Environment Mapping Using Distributed Static 3D Sensor Nodes
2018
This paper presents a system architecture for mapping and real-time monitoring of a relatively large industrial robotic environment of size 10 m × 15 m × 5 m. Six sensor nodes with embedded computing power and local processing of the 3D point clouds are placed close to the ceiling. The system architecture and data processing is based on the Robot Operating System (ROS) and the Point Cloud Library (PCL). The 3D sensors used are the Microsoft Kinect for Xbox One and point cloud data is collected at 20 Hz. A new manual calibration procedure is developed using reflective planes. The specified range of the used sensor is 0.8 m to 4.2 m, while depth data up to 9 m is used in this paper. Despite t…
Data-driven decision support to reduce "driving-under the influence of alcohol" offenses
2018
Extracting valuable knowledge from data to support decision making is a widely practiced trend. Data-driven decision support (DDDS) provides insight for decision makers by exploring and extracting underlying patterns within a dataset. This thesis covers the process of DDDS in reducing driving under the influence of alcohol (DUI) offenses by introducing proposed prison sentences. In this thesis, DDDS is applied to a DUI dataset by analyzing patterns in the dataset and by introducing proposed prison sentences for offenders to reduce the number of DUI cases. Background theories in data mining, machine learning, optimization and decision science that are related to the thesis project are also c…
An open-source computational and data resource to analyze digital maps of immunopeptidomes
2015
We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources by SWATH mass spectrometry (MS). This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the de…
Design, construction and cooling system performance of a prototype cryogenic stopping cell for the Super-FRS at FAIR
2015
A cryogenic stopping cell for stopping energetic radioactive ions and extracting them as a low energy beam was developed. This first ever cryogenically operated stopping cell serves as prototype device for the Low-Energy Branch of the Super-FRS at FAIR. The cell has a stopping volume that is 1 m long and 25 cm in diameter. Ions are guided by a DC field along the length of the stopping cell and by a combined RF and DC fields provided by an RE carpet at the exit-hole side. The ultra-high purity of the stopping gas required for optimum ion survival is reached by cryogenic operation. The design considerations and construction of the cryogenic stopping cell, as well as some performance character…