Search results for "PPRE"

Endogenous Myoglobin in Breast Cancer Is Hypoxia-inducible by Alternative Transcription and Functions to Impair Mitochondrial Activity

2011

Recently, immunohistochemical analysis of myoglobin (MB) in human breast cancer specimens has revealed a surprisingly widespread expression of MB in this nonmuscle context. The positive correlation with hypoxia-inducible factor 2α (HIF-2α) and carbonic anhydrase IX suggested that oxygen regulates myoglobin expression in breast carcinomas. Here, we report that MB mRNA and protein levels are robustly induced by prolonged hypoxia in breast cancer cell lines, in part via HIF-1/2-dependent transactivation. The hypoxia-induced MB mRNA originated from a novel alternative transcription start site 6 kb upstream of the ATG codon. MB regulation in normal and tumor tissue may thus be fundamentally diff…

The Hippo Show Must Go On: YAP Activation as a Therapeutic Strategy in Colorectal Cancer

2020

The role of Hippo pathway in colorectal cancer (CRC) initiation and progression has been controversial. In this issue of Cell Stem Cell, Cheung et al. (2020) shed new light on a distinct function of the transcriptional co-activator YAP as a tumor suppressor and Wnt pathway inhibitor in CRC.

2020

Through a recent upsurge of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic, the clinical assessment of most of the coronavirus disease 19 (COVID-19) patients clearly presents a health condition with the loss of oro-naso-sensory (ONS) perception, responsible for the detection of flavor and savor. These changes include anosmia and dysgeusia. In some cases, these clinical manifestations appear even before the general flu-like symptoms, e.g., sore throat, thoracic oppression and fever. There is no direct report available on the loss of these chemical senses in obese COVID-19 patients. Interestingly, obesity has been shown to be associated with low ONS cues. These alterati…

Les étudiants de la génération Y en formation

2013

National audience; La génération Y suscite débats et questionnements au niveau pédagogique. C'est actuellement celle qui constitue la majorité des étudiants en formation paramédicale. Peu désireuse d'un enseignement dispensant uniquement des savoirs, cette génération demande que le formateur s'adapte aux étudiants pour susciter leur intérêt et donc leur engagement dans la formation. Cela passe par certaines caractéristiques générationnelles, à commencer par la relation entre le formateur et les étudiants mais aussi par le travail en groupe, l'apprentissage par essais-erreurs, ou encore l'utilisation de nouvelles technologies. Ce texte propose un éclairage sur ces différents points pour ques…

The Breast Size Satisfaction Survey (BSSS): Breast size dissatisfaction and its antecedents and outcomes in women from 40 nations

2020

The Breast Size Satisfaction Survey (BSSS) was established to assess women's breast size dissatisfaction and breasted experiences from a cross-national perspective. A total of 18,541 women were recruited from 61 research sites across 40 nations and completed measures of current-ideal breast size discrepancy, as well as measures of theorised antecedents (personality, Western and local media exposure, and proxies of socioeconomic status) and outcomes (weight and appearance dissatisfaction, breast awareness, and psychological well-being). in the total dataset, 47.5 % of women wanted larger breasts than they currently had, 23.2 % wanted smaller breasts, and 29.3 % were satisfied with their curr…

ACT for sleep - Internet-delivered self-help ACT for sub-clinical and clinical insomnia : A randomized controlled trial

2019

Background: Sleep disturbances are a common health problem. New and more accessible alternatives are needed to improve the availability of psychological treatments for insomnia. - Objective: The aim of the present study was to investigate the effects of a self-help Acceptance and Commitment Therapy-based web-intervention for sleep disturbances. - Method: Participants (N = 86) reporting symptoms of insomnia were randomly assigned to an Internet-delivered ACT (iACT, n = 43) or a control condition (WLC, n = 40) and assessed with standardized self-report measures related to sleep (ISI, BNSQ, ESS, DBAS), psychological symptoms (BDI-II, SCL-90), life satisfaction, and ACT-related processes (AAQ-2…

Confirmatory factor analysis and psychometric properties of the Emotion Regulation Questionnaire in participants with personality disorders

2021

Emotional dysregulation is a key symptom in participants with personality disorders. The Emotional Regulation Questionnaire (ERQ) has been studied with nonclinical samples; however, it is necessary to confirm the factorial structure of the ERQ in participants with personality disorders. The aims of the present study were to confirm the factorial structure of the Spanish version of the ERQ and analyse its psychometric properties as well as the association between the ERQ and the Borderline Symptoms List (BSL-23) and the Difficulties in Emotion Regulation Scale (DERS). The overall sample was composed of 250 patients with personality disorders, of whom 195 met the criteria for borderline perso…

L'accroissement de l'effet de l'origine sociale sur la performance scolaire : par où est-il passé ?

2017

International audience; L'ampleur considérable des inégalités sociales de performances scolaires interroge fortement l'équité de l'école. Nous cherchons, dans ce travail, à mettre en lumière les facteurs de l'accroissement récent de ces inégalités par le biais d'indicateurs disponibles dans les données des enquêtes PISA (2003 et 2012). Nous étudions d'abord l'évolution des différentes composantes de l'indicateur multicritère par lequel l'OCDE mesure le plus souvent le milieu social. Ensuite, nous modélisons, par une analyse en pistes causales, la décomposition de l'effet du statut professionnel des parents sur les performances afin de saisir par quoi il transite. Sont mobilisés des facteurs…

The magic of patriarchal oppression in Alan Moore and Eddie Campbell’s From Hell

2017

ABSTRACTIn From Hell, Alan Moore establishes systemic patriarchal sexual violence against the backdrop of Victorian London. While rape and other acts of physical repression are easily linked to the notion of sexual violence, Moore’s treatment is concentrated on the society as a whole. His anti-hero, physician Sir William Gull, justifies the serial murders and dissection rituals as a necessary continuation of Victorian inequality and as a symbolic manifestation of patriarchy’s counterattack. Linking ancient religion and mythology to a thousand years of British history, the sexual violence in From Hell is cast in the frame of a successful victory of patriarchy over matriarchy. Alan Moore’s pa…

Gender gap in Swiss vocational education and training teachers’ economics content knowledge and the role of teaching experience

2019

In the commercial sector, which is of crucial importance to the Swiss economy among other countries, a large number of apprentices are trained on a vocational education and training programme every year. Besides other subjects, the subject Economics and Society forms an integral part of the vocational education and training curriculum and serves to prepare apprentices for professional, economic and civic participation. Although content knowledge is widely considered necessary to both teaching quality and student achievement, little is known about the subject-specific content knowledge of Swiss Economics and Society teachers. As previous research has shown a gender gap in the content knowled…