Search results for "PREDICT"
showing 10 items of 2174 documents
Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
2012
Hepatotoxicity is a major reason for drug nonapprovals and withdrawals. The multiparametric analysis of xenobiotic toxicity at the single cells level using flow cytometry and cellular imaging-based approaches, such as high-content screening (HCS) technology, could play a key role in the detection of toxicity and the classification of compounds based on patterns of cellular injury. This study aimed to develop and validate a practical, reproducible, in vitro multiparametric cell-based protocol to assess those drugs that are potentially hepatotoxic to humans and to suggest their mechanisms of action. The assay was applied to HepG2 human cell line cultured in 96-well plates and exposed to 78 di…
Event-Related Potentials (ERP) Indices of Motivation during the Effort Expenditure for Reward Task
2020
Dynamic and temporal facets of the various constructs that comprise motivation remain to be explored. Here, we adapted the Effort Expenditure for Reward Task, a well-known laboratory task used to evaluate motivation, to study the event-related potentials associated with reward processing. The Stimulus Preceding Negativity (SPN) and the P300 were utilized as motivation indicators with high density electroencephalography. The SPN was found to be more negative for difficult choices compared to easy choices, suggesting a greater level of motivation, at a neurophysiological level. The insula, a structure previously associated with both effort discounting and prediction error, was concomitantly a…
Lesion load may predict long-term cognitive dysfunction in multiple sclerosis patients
2015
Background: Magnetic Resonance Imaging (MRI) techniques provided evidences into the understanding of cognitive impairment (CIm) in Multiple Sclerosis (MS). Objectives: To investigate the role of white matter (WM) and gray matter (GM) in predicting long-term CIm in a cohort of MS patients. Methods: 303 out of 597 patients participating in a previous multicenter clinical-MRI study were enrolled (49.4% were lost at follow-up). The following MRI parameters, expressed as fraction (f) of intracranial volume, were evaluated: cerebrospinal fluid (CSF-f), WM-f, GM-f and abnormal WM (AWM-f), a measure of lesion load. Nine years later, cognitive status was assessed in 241 patients using the Symbol Dig…
Ecological correlates of Spanish preschoolers’ physical activity during school recess
2017
Early childhood education (ECE) institutions may be one place for young children to obtain a significant proportion of their daily physical activity (PA). Even though young children are generally considered to be very active, and recess time is considered an important environmental factor for promoting PA, evidence suggests that young children spend most recess time participating in sedentary activities. To our knowledge there have been no systematic evaluations of the PA levels and patterns during recess time in Spanish preschool children. Therefore, the aims of this study were threefold: (a) to analyse the PA patterns and sedentary behaviour during recess time in outdoor ECE environments…
An empirical assessment of the Feltham-Ohlson models considering the sign of abnormal earnings
2006
Abstract This paper provides an empirical assessment of the Feltham-Ohlson models, distinguishing between firms with positive and negative abnormal earnings. Abnormal earnings persistence and conservatism parameters differ for these two groups; this implies different earnings prediction models and valuation functions for both profit-making and loss-making firms. The analysis refers to the period 1991-1999 and uses a sample of Spanish firms quoted on the Madrid S.E. The results suggest that our contextual approach is more useful than the non-contextual one to predict future abnormal earnings and explain current prices. Although the Ohlson (1995) model is accurate in forecasting future abnorm…
Polar motion prediction using the combination of SSA and Copula-based analysis
2018
The real-time estimation of polar motion (PM) is needed for the navigation of Earth satellite and interplanetary spacecraft. However, it is impossible to have real-time information due to the complexity of the measurement model and data processing. Various prediction methods have been developed. However, the accuracy of PM prediction is still not satisfactory even for a few days in the future. Therefore, new techniques or a combination of the existing methods need to be investigated for improving the accuracy of the predicted PM. There is a well-introduced method called Copula, and we want to combine it with singular spectrum analysis (SSA) method for PM prediction. In this study, first, we…
Waves to Weather: Exploring the Limits of Predictability of Weather
2021
AbstractPrediction of weather is a main goal of atmospheric science. Its importance to society is growing continuously due to factors such as vulnerability to natural disasters, the move to renewable energy sources, and the risks of climate change. But prediction is also a major scientific challenge due to the inherently limited predictability of a chaotic atmosphere, and has led to a revolution in forecasting methods as we have moved to probabilistic prediction. These changes provide the motivation for Waves to Weather (W2W), a major national research program in Germany with three main university partners in Munich, Mainz, and Karlsruhe. We are currently in the second 4-yr phase of our pla…
Exploiting Maximum Entropy method and ASTER data for assessing debris flow and debris slide susceptibility for the Giampilieri catchment (north-easte…
2016
This study aims at evaluating the performance of the Maximum Entropy method in assessing landslide susceptibility, exploiting topographic and multispectral remote sensing predictors. We selected the catchment of the Giampilieri stream, which is located in the north-eastern sector of Sicily (southern Italy), as test site. On 1 October 2009, a storm rainfall triggered in this area hundreds of debris flow/avalanche phenomena causing extensive economical damage and loss of life. Within this area a presence-only-based statistical method was applied to obtain susceptibility models capable of distinguishing future activation sites of debris flow and debris slide, which where the main source of fai…
Probabilistic Forecast for Northern New Zealand Seismic Process Based on a Forward Predictive Kernel Estimator
2011
In seismology predictive properties of the estimated intensity function are often pursued. For this purpose, we propose an estimation procedure in time, longitude, latitude and depth domains, based on the subsequent increments of likelihood obtained adding an observation one at a time. On the basis of this estimation approach a forecast of earthquakes of a given area of Northern New Zealand is provided, assuming that future earthquakes activity may be based on the smoothing of past earthquakes.
SECULAR MEAN REVERSION AND LONG-RUN PREDICTABILITY OF THE STOCK MARKET
2016
Empirical financial literature documents the evidence of mean reversion in stock prices and the absence of out-of-sample return predictability over periods shorter than 10 years. The goal of this paper is to test the random walk hypothesis in stock prices and return predictability over periods longer than 10 years. Specifically, using 141 years of data, this paper begins by performing formal tests of the random walk hypothesis in the prices of the real S&P Composite Index over increasing time horizons up to 40 years. Even though our results cannot support the conventional wisdom which says that the stock market is safer for long-term investors, our findings speak in favor of the mean revers…