Search results for "PREM"

Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs)

2020

[Image: see text] Translational readthrough-inducing drugs (TRIDs) rescue the functional full-length protein expression in genetic diseases, such as cystic fibrosis, caused by premature termination codons (PTCs). Small molecules have been developed as TRIDs to trick the ribosomal machinery during recognition of the PTC. Herein we report a computational study to identify new TRID scaffolds. A pharmacophore approach was carried out on compounds that showed readthrough activity. The pharmacophore model applied to screen different libraries containing more than 87000 compounds identified four hit-compounds presenting scaffolds with diversity from the oxadiazole lead. These compounds have been s…

L’ évolution des assemblages lithiques des niveaux du Paléolithique moyen de l’Abrigo de la Quebrada (Valencia, Espagne)

2018

L’Abrigo de la Quebrada propose une séquence stratigraphique importante, avec neuf niveaux dont sept présentent des preuves d’occupation appartenant au Paléolithique moyen. De plus, l’existence d’un niveau stérile, le VI, séparant les niveaux supérieurs (II à V) des niveaux inférieurs (VII à IX), permet d’évaluer, dans une perspective diachronique, les changements constatés sur les différentes matiàres premières et sur les systémes de débitage employés pour chacune de ces deux grandes phases. Ces donne´ es sont compare´ es a` d’autres sites contemporains, dans le but d’e´valuer les normes technologiques et la gestion des ressources des ne´ andertaliens dans la zone ge´ographique de la re´gi…

Dental wear at macro- and microscopic scale in rabbits fed diets of different abrasiveness: A pilot investigation

2020

To differentiate the effects of internal and external abrasives on tooth wear, we performed a controlled feeding experiment in rabbits fed diets of varying phytolith content as an internal abrasive and with addition of sand as an external abrasive. 13 rabbits were each fed one of the following four pelleted diets with different abrasive characteristics (no phytoliths: lucerne L; phytoliths: grass G; more phytoliths: grass and rice hulls GR; phytoliths plus external abrasives: grass, rice hulls and sand GRS) for two weeks. At the end the feeding period, three tooth wear proxies were applied to quantify wear on the cheek teeth at macroscopic and microscopic wear scales: CT scans were obtained…

Stage boundaries, global stratigraphy, and the time scale: towards a simplification

2004

International audience; This paper examines four facets of stratigraphic terminology and usage considered faulty and proposes corrective measures. The four perfectible areas are: (1) The system of dual nomenclature requiring discrete terminologies for the superpositional and temporal aspects of rock units. (2) The premise that a GSSP establishes the base of a stage as being coincident with the top of the preceding stage rather than simply defining it as the boundary between stages. (3) The rejection of supplementary (auxiliary) sections that would broaden the knowledge of a GSSP and enlarge the area in which it is easily usable. (4) The current dual system of nomenclature for Precambrian an…

When less means more: evolutionary and developmental hypotheses in rodent molars.

2012

10 pages; International audience; Tooth number in rodents is an example of reduction in evolution. All rodents have a toothless diastema lacking canine and most premolars present in most other mammals. Whereas some rodent lineages retained one premolar (p4), many others lost it during evolution. Recently, an 'inhibitory cascade' developmental model (IC) has been used to predict how the first molar (m1) influences the number and relative sizes of the following distal molars (m2 and m3). The model does not, however, consider the presence of premolars, and here we examine whether the premolar could influence and constrain molar proportions during development and evolution. By investigating a l…

Il barocco nel diritto. Le "Decisiones" dei supremi tribunali del "Regnum Siciliae"

2017

Analysis of Activity States of Local Neuronal Microcircuits in Mouse Brain

2018

Time series of neuronal activity corresponding to different activity states in mouse brain are analyzed in the time domain and the time-frequency domain. The signals are associated with either a slow wave brain state or a persistent brain state. For both states, characteristic spectral features are identified and a simple detector is proposed that is able to identify the brain state with low latency and high accuracy. In practice, being able to monitor the brain state online and in real time is crucial for improved in vivoexperiments and, ultimately, for a causal understanding of brain dynamics.

Visualization of Simulated Arrhythmias due to Gap Junctions

2018

New computational models are able to simulate details of cardiac cell networks. Their results allow a better understanding of the functionality of the heart and suggest possible actions to reduce non-fatal premature beats that can give rise to serious diseases. We developed a user-friendly interface to organize Neuron simulations and to present in real-time a three-dimensional representation of the electrical activity due to the gap junctions which interconnect the cells inside cardiac tissues. All physiological parameters were set according to real experimental observations and compared against different types of arrhythmias, retrieved from the Physionet Data Base.

Stature and long-term labor market outcomes: Evidence using Mendelian randomization.

2017

We use the Young Finns Study (N = ∼2000) on the measured height linked to register-based long-term labor market outcomes. The data contain six age cohorts (ages 3, 6, 9, 12, 15 and 18, in 1980) with the average age of 31.7, in 2001, and with the female share of 54.7. We find that taller people earn higher earnings according to the ordinary least squares (OLS) estimation. The OLS models show that 10 cm of extra height is associated with 13% higher earnings. We use Mendelian randomization, with the genetic score as an instrumental variable (IV) for height to account for potential confounders that are related to socioeconomic background, early life conditions and parental investments, which ar…

Inferior alveolar nerve trajectory, mental foramen location and incidence of mental nerve anterior loop

2017

Background: Injury of the inferior alveolar nerve (IAN) is a serious intraoperative complication that may occur during routine surgical procedures, such as dental implant placement or extraction of impacted teeth. Thus, the purpose of this study was to analyze the trajectory of the mandibular canal (MC), the location of the mental foramen (MF) and the presence and extension of an anterior loop of the mental nerve (AL). Study Design: In this cross-sectional study, a total of 348 CBCTs were analyzed. Distances from MC to the surface of the basal, medial and lateral cortical of the mandible were measured at the level of the second molar, first molar and second premolar. Location of the MF rela…