Search results for "PREP"
showing 10 items of 1334 documents
Precipitation responses to ENSO and IOD in the Maldives: Implications of large-scale modes of climate variability in weather-related preparedness
2020
Abstract This research seeks to address the extent to which indices of large-scale modes of climate variability (El Nino Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD)) can be linked to physical differences in the local mean and extreme rainfall conditions experienced in the Maldives in order to suggest implications for disaster risk reduction (DRR). While some significant differences in precipitation metrics do occur at the local level between different phases of the large-scale modes of climate variability studied, they do not occur for all sites studied. While the constrained availability of historical meteorological data in the region is a limiting factor in this analysis, th…
Yhteistyön mahdollisuudet – lukiokoulutukseen valmistava koulutus kielellistyvässä maailmassa
2018
Tassa tutkimuksessa selvitetaan sita, millaisia kasityksia rehtoreilla, opettajilla ja opiskelijoilla on vuorovaikutuksen mahdollistavasta toiminnasta eli yhteistyosta Lukiokoulutukseen valmistavan koulutuksen (LUVA) ja muun lukiotoiminnan valilla. Edellisen lisaksi tarkastellaan sita, ilmeneeko LUVA-koulutuksessa aineiston perusteella kielenoppimista tukevaa eri kielten limittaista kayttoa (engl. translanguaging ). Tutkimuksen teoreettinen tausta pohjautuu kielenoppimisen kayttopohjaiseen ajatteluun eli siihen, etta oppimisessa tarkeimpana nahdaan kielenkaytto ja vuorovaikutus. Taman artikkelin keskeinen teoreettinen kasite on translanguaging , joka nahdaan vastakohtana yksikielisyyden …
El desarrollo de un programa de evaluación online para la preparación de la versión informatizada del First Certificate in English
2012
Las exigencias actuales de la sociedad global de la comunicación han llevado a un gran número de exámenes oficiales de idiomas a adoptar el formato informatizado e incluso online, como ocurre con Cambridge First Certificate in English (FCE). El surgimiento de su versión informatizada hace que aumente la demanda de materiales preparatorios y de evaluación de calidad que tengan en cuenta las características del nuevo formato de examen, planteando ejercicios en concordancia. En este contexto se ha desarrollado el programa preparatorio y de evaluación InGenio FCE Online Tester, en el seno del grupo de investigación CAMILLE, del Departamento de Lingüística Aplicada de la Universitat Politècnica …
5-Fluorouracil: various kinds of loaded liposomes: encapsulation efficiency, storage stability and fusogenic properties
1993
Abstract This paper describes the optimization of 5-fluorouracil (5-FU) loaded liposome formulations. Four different preparation procedures were carried out, obtaining two types of multilamellar vesicles (MLVs), stable plurilamellar vesicles (SPLVs) and large unilamellar vesicles (LUVs). In this study various phospholipids were used to prepare liposomes. The lipid mixtures containing diplamitoylphosphatidylserine seemed the best for biological 5-FU delivery by presenting better encapsulation efficiency parameters, serum and storage stability, and fusogenic properties, which are an important factor prerequisite for in vivo liposome-cell interaction. The presence of cholesterol in the liposom…
The antifibrotic potential of a sustained release formulation of a PDGF beta-receptor targeted rho kinase inhibitor
2019
Rho kinase activity in hepatic stellate cells (HSCs) is associated with activation, transformation and contraction of these cells, leading to extracellular matrix production and portal hypertension in liver cirrhosis. Inhibition of rho kinase activity can reduce these activities, but may also lead to side effects, for instance systemic hypotension. This can be circumvented by liver-specific delivery of a rho kinase inhibitor to effector cells. Therefore, we targeted the rho kinase inhibitor Y27632 to the key pathogenic cells in liver fibrosis, i.e. myofibroblasts including activated HSCs that highly express the PDGF beta-receptor, using the drug carrier pPB-MSA. This carrier consists of mou…
Prescription rates of common medications in patients with decompensated cirrhosis in Germany
2021
Adequate pharmacological treatment is of pivotal importance to improve prognosis in patients with decompensated liver cirrhosis. We studied the adherence to recommended pharmacological treatments as secondary prevention in cirrhotic patients following a first decompensation in German primary care.Using the Disease Analyzer Database, the current study sample included patients with liver cirrhosis who had an initial diagnosis of a first decompensation event between 2015 and 2018 (index date) and a follow-up time of at least 6 months after the index date. Pharmacological treatments following the 6 months after the index date were studied.The study included 1538 patients with a first decompensa…
Real-world effectiveness of long acting aripiprazole: Treatment persistence and its correlates in the Italian clinical practice
2019
Abstract Objectives To identify the variables that are associated with persistence to Aripiprazole-Long Acting (A-LAI), in adult patients with schizophrenia. Methods Observational, retrospective, non-interventional study involving 261 patients with schizophrenia. Results Eighty-six percent of study subjects were persistent for at least 6 months. All subjects with baseline CGI-S of 1 or 2, 95% of subjects with CGI-S of 3, 86% with CGI-S of 4, 82% of subjects with CGI-S of 5, 73% of subjects with CGI of 6 and 90% of subjects with CGI of 7 were persistent. A-LAI treatment continuation rate was higher in patients with: 1) baseline CGI score ≤ 4; 2) schizophrenia dimension (LDPS) mania score ≤ 5…
The application of molecular imprinting technology to solid phase extraction
2001
In parallel to a long lasting search for universal multi-purpose sorbents, the area of solid phase extraction (SPE) is recently experiencing a rapid development of new types of tailor-made class specific or compound-specific sorbents which are designed to respond to the increasing demand for selectivity and efficiency in sample clean-up prior to quantification. An important issue here is the enrichment and clean-up of complex samples, such as environmental waters, sediments, biofluids and foodstuffs prior to detection. This because the analyte is often present in low concentration in a complex mixture of similar compounds and therefore needs to be isolated and enriched in order to be detect…
Off-label long acting injectable antipsychotics in real-world clinical practice: a cross-sectional analysis of prescriptive patterns from the STAR Ne…
2022
Introduction: Information on the off–label use of Long–Acting Injectable (LAI) antipsychotics in the real world is lacking. In this study, we aimed to identify the sociodemographic and clinical features of patients treated with on– vs off–label LAIs and predictors of off–label First– or Second–Generation Antipsychotic (FGA vs. SGA) LAI choice in everyday clinical practice. Method: In a naturalistic national cohort of 449 patients who initiated LAI treatment in the STAR Network Depot Study, two groups were identified based on off– or on–label prescriptions. A multivariate logistic regression analysis was used to test several clinically relevant variables and identify those associated with th…
Iron‐Catalyzed Cross‐Couplings in the Synthesis of Pharmaceuticals: In Pursuit of Sustainability
2018
The scarcity of precious metals has led to the development of sustainable strategies for metal-catalyzed cross-coupling reactions. The establishment of new catalytic methods using iron is attractive owing to the low cost, abundance, ready availability, and very low toxicity of iron. In the last few years, sustainable methods for iron-catalyzed cross-couplings have entered the critical area of pharmaceutical research. Most notably, iron is one of the very few metals that have been successfully field-tested as highly effective base-metal catalysts in practical, kilogram-scale industrial cross-couplings. In this Minireview, we critically discuss the strategic benefits of using iron catalysts a…