Search results for "PROFILE"
showing 10 items of 915 documents
Experimental study of boulder concentration effect on flow resistance in gravel bed channels
2021
Abstract Previous studies demonstrated that for open channel flows the power velocity profile can be integrated to obtain the flow resistance law. In this paper the relationship between Γ coefficient of the power velocity distribution, the channel slope and Froude number (Eq. (9) ) is firstly presented. Then the measurements carried out in a laboratory flume covered by hemispheric elements for two different hydraulic conditions (partially inundated and inundated) are used to calibrate this relationship. These elements are placed with a square arrangement and have a concentration range 4–64%. For the two investigated hydraulic conditions, this analysis demonstrates that the relationship to e…
Evaluating the Effects of Sediment Transport on Pipe Flow Resistance
2021
In this paper, the applicability of a theoretical flow resistance law to sediment-laden flow in pipes is tested. At first, the incomplete self-similarity (ISS) theory is applied to deduce the velocity profile and the corresponding flow resistance law. Then the available database of measurements carried out by clear water and sediment-laden flows with sediments having a quasi-uniform sediment size and three different values of the mean particle diameter Dm (0.88 mm, 0.41 mm and 0.30 mm) are used to calibrate the Γ parameter of the power-velocity profile. The fitting of the measured local velocity to the power distribution demonstrates that (i) for clear flow the exponent δ can be estimated b…
Testing a theoretically-based overland flow resistance law by Emmett’s database
2021
Abstract The main aim of this paper was to test a recently theoretically deduced flow resistance equation, based on a power-velocity profile, using a wide database of available measurements carried out in laboratory and field experimental runs with overland flow under simulated rainfall. In comparison with previous calibrations and validations of this theoretically deduced flow resistance equation, the used database by Emmett is characterized by a wide range of rainfall intensities (from 79.2 to 303.5 mm h−1 for laboratory runs and from 178.3 to 215.9 mm h−1 for field investigations) and bed slopes (from 0.33 to 17% for laboratory runs and from 2.9 to 33.2% for field investigations). For th…
Impacts of roundabouts in suburban areas on congestion-specific vehicle speed profiles, pollutant and noise emissions: an empirical analysis
2019
Abstract Increasing concern about global warming and air quality has meant an increasing use of energetic and environmental indicators in roundabout design. This research compares different suburban roundabouts in terms of traffic performance, pollutant and noise emissions through an integrated empirical assessment. Field measurements were carried out with a light duty vehicle in single-lane (SL), compact two-lane (CTL) and multi-lane (ML) roundabouts using Portable Emission Measurements Systems, On-Board Diagnostic scan tool and Sound Level Meter, to measure real-world exhaust emissions, engine activity and acoustic data, respectively. Afterwards, predictive discrete choice models that cor…
Results of a literature review on methods for estimating buildings energy demand at district level
2019
Abstract In the framework of distributed energy planning, evaluating reliable energy profiles of different sectors has a prominent role. At the same time, it is a quite challenging task, since the availability of actual energy profiles of buildings at the district level is not widespread. A survey of over 70 studies in scientific literature has been accomplished and a set of criteria has been defined for classifying the selected contributions based on the energy demand data features, source and/or estimation methods, highlighting the ones adopting hourly energy profiles. As final results, tables summarizing the main methods characteristics and a selection of studies providing directly useab…
Internet Gaming Disorder profiles and their associations with social engagement behaviours.
2021
Abstract Internet Gaming Disorder (IGD), describes the abuse of Internet games with detrimental impact to the real-life social engagement of some gamers. Indeed, evidence suggests that gamers differ on the severity and way in which they express IGD symptoms, as well as their social engagement behaviours. The present study aimed to: a) profile gamers regarding their experience of IGD symptoms and; b) examine how different IGD profiles varied on social engagement behaviours. Methods: A sample consisting of 1032 gamers (18–72 years, Mage = 24) was assessed with the Internet Gaming Disorder Scale 9 Items Short Form (IGDS9-SF) and social engagement questions regarding their participation in empl…
Highly purified chondroitin sulfate: a literature review on clinical efficacy and pharmacoeconomic aspects in osteoarthritis treatment
2020
AbstractOsteoarthritis (OA) is the most prevalent musculoskeletal disease and a major cause of negative relevant outcomes, associated with an ever-increasing societal burden. Pharmaceutical-grade chondroitin sulfate (CS) was repeatedly reported to reduce pain and improve function in patients with OA. This article aims to review the evidence for the role of highly purified (hp) CS (Condrosulf®, IBSA) in the treatment of OA. We collected and reported evidence concerning (1) efficacy of hpCS 800 mg/day in the treatment of OA affecting the knee, hand and hip; (2) efficacy and safety of hpCS 1200 mg/day also in the oral gel formulation; (3) the safety profile of hpCS; (4) the difference of hpCS …
Clinical pharmacology and safety profile of esomeprazole, the first enantiomerically pure proton pump inhibitor
2001
Awareness of important differences in the pharmacological profile of individual optical isomers of chiral drugs led to the development of esomeprazole, the S-isomer of omeprazole, a new pharmacological entity designed to improve the clinical outcome of available proton pump inhibitors in the management of acid-related disorders. The superior acid control achieved by esomeprazole is mainly due to an advantageous metabolism compared with racemate omeprazole, leading to improved bioavailability and to enhanced delivery of the drug to the gastric proton pump.
Ketamine in acute phase of severe traumatic brain injury “an old drug for new uses?”
2021
AbstractMaintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.
Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: analysis on cytokines and lipid profile
2021
Abstract Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an anti-inflammatory effect.