Search results for "PROGNOSIS"

showing 10 items of 2052 documents

Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpo…

2009

Hypertension guidelines advise aggressive blood pressure (BP) lowering in patients with diabetes or high cardiovascular risk, but supporting evidence is limited. We analysed the impact of BP on cardiovascular events in well treated high-risk patients enrolled in a large clinical trial (Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial).Twenty-five thousand five hundred and eighty-eight patients with atherosclerotic disease or diabetes with organ damage, tolerant to angiotensin-converting enzyme inhibitors, were randomized to ramipril, telmisartan or both. We related the primary composite outcome and its components to: baseline SBP; SBP changes from baseline to…

RamiprilMalemedicine.medical_specialtyPhysiologyAngiotensin-Converting Enzyme InhibitorsBlood PressureBenzoateslaw.inventionRandomized controlled trialDouble-Blind MethodRamiprillawInternal medicineInternal MedicinemedicineHumansTelmisartanRisk factorAntihypertensive AgentsAgedVascular diseasebusiness.industryMiddle Agedmedicine.diseasePrognosisAngiotensin IISurgeryClinical trialBlood pressureTreatment OutcomeHypertensionCardiologyBenzimidazolesFemaleTelmisartanCardiology and Cardiovascular Medicinebusinessmedicine.drugJournal of hypertension
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Re-irradiation With Carbon Ion Radiotherapy for Pelvic Rectal Cancer Recurrences in Patients Previously Irradiated to the Pelvis

2020

Background/Aim: Re-irradiation of locally recurrent rectal cancer poses challenges due to the proximity of critical organs, such as the bowel. This study aimed at evaluating the safety and efficacy of re-irradiation with Carbon Ion Radiotherapy (CIRT) in rectal cancer patients with local recurrence. Patients and Methods: Between 2014 and 2018, 14 patients were treated at the National Center of Oncological Hadrontherapy (CNAO Foundation) with CIRT for locally recurrent rectal cancer. Results: All patients concluded the treatment. No G≥3 acute/late reaction nor pelvic infections were observed. The 1-year and 2-year local control rates were, 78% and 52%, respectively, and relapse occurred clos…

Re-IrradiationAdultMaleCancer Researchmedicine.medical_specialtyColorectal cancerHeavy Ion RadiotherapyKaplan-Meier EstimateGeneral Biochemistry Genetics and Molecular BiologyPelvisRe-Irradiation03 medical and health sciences0302 clinical medicineSettore MED/36 - Diagnostica per Immagini e RadioterapiamedicineHumansIn patientRectal cancer recurrenceCarbon ion radiotherapy; Rectal cancer recurrence; Reirradiation; Adult; Aged; Female; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Recurrence Local; Pelvis; Prognosis; Rectal Neoplasms; Tomography X-Ray Computed; Treatment Outcome; Heavy Ion Radiotherapy; Re-IrradiationTomographyPelvisRecurrent Rectal CancerReirradiationAgedPharmacologyddc:617business.industryRectal NeoplasmsMiddle Agedmedicine.diseasePrognosisMagnetic Resonance ImagingX-Ray Computedmedicine.anatomical_structureNeoplasm RecurrenceTreatment OutcomeLocalCarbon ion radiotherapy030220 oncology & carcinogenesisMetastasis free survivalCarbon Ion RadiotherapyFemaleRadiologyNeoplasm Recurrence LocalbusinessTomography X-Ray ComputedPelvic InfectionResearch ArticleFollow-Up Studies
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Prognostic indicators in pediatric clinically isolated syndrome

2017

To assess prognostic factors for a second clinical attack and a first disability worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of Multiple Sclerosis (MS) patients. Objective: To assess prognostic factors for a second clinical attack and a first disability-worsening event in pediatric clinically isolated syndrome (pCIS) suggestive of multiple sclerosis (MS) patients. Methods: A cohort of 770 pCIS patients was followed up for at least 10 years. Cox proportional hazard models and Recursive Partitioning and Amalgamation (RECPAM) tree-regression were used to analyze data. Results: In pCIS, female sex and a multifocal onset were risk factors for a second clinical att…

RegistrieMaleMultiple SclerosisAdolescentAdolescent; Age of Onset; Child; Demyelinating Diseases; Female; Follow-Up Studies; Humans; Male; Multiple Sclerosis; Prognosis; Retrospective Studies; Risk Factors; Disease Progression; Registries; Neurology; Neurology (clinical)PrognosiONSET MULTIPLE-SCLEROSISCHILDHOODCHILDRENPARACLINICAL FEATURESDISABILITY PROGRESSIONNOFollow-Up StudieRisk FactorsRetrospective Studieprognostic indicatorsMultiple Sclerosipediatric multiple sclerosis prognosis indicatorsHumansRegistriesAge of OnsetChildOPTIC NEURITISRetrospective StudiesRisk FactorDemyelinating DiseaseNATURAL-HISTORYPrognosismultiple sclerosis clinically isolated syndrome prognostic indicatorsNeurologyTRANSVERSE MYELITISclinically isolated syndromeINTERFERON BETA-1BDisease ProgressionSettore MED/26 - NeurologiaFemaleNeurology (clinical)FOLLOW-UPDemyelinating DiseasesFollow-Up StudiesHuman
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The actual management of colorectal liver metastases

2020

Colorectal cancer is one of the most frequent cancers in the world and between 50% and 60% of patients will develop colorectal liver metastases (CRLM) during the disease. There have been great improvements in the management of CRLM during the last decades. The combination of modern chemotherapeutic and biological systemic treatments with aggressive surgical resection strategies is currently the base for the treatment of patients considered unresectable until few years ago. Furthermore, several new treatments for the local control of CRLM have been developed and are now part of the arsenal of multidisciplinary teams for the treatment of these complex patients. The aim of this review was to s…

ReoperationSurgical resectionmedicine.medical_specialtyOrganoplatinum CompoundsColorectal cancerLeucovorinDisease030230 surgery03 medical and health sciencesHepatic Artery0302 clinical medicineAntineoplastic Combined Chemotherapy ProtocolsHepatectomyHumansInfusions Intra-ArterialMedicineMicrowavesRadiofrequency Ablationbusiness.industryGeneral surgeryLiver NeoplasmsMargins of ExcisionPrognosismedicine.diseaseLiver TransplantationElectroporation030220 oncology & carcinogenesisCamptothecinSurgeryFluorouracilColorectal NeoplasmsbusinessMinerva Chirurgica
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Reflections on communication of disease prognosis and life expectancy by patients with colorectal cancer undergoing palliative care: a qualitative st…

2019

ObjectivesPatients with colorectal cancer undergoing palliative treatment receive extensive treatment-related information throughout their disease trajectory. We aimed to explore the experiences of patients with incurable colorectal cancer while in palliative care and their reflections on the information provided by physicians and nurses. Our main focus was the patients’ thoughts about how information about disease status and life expectancy was communicated, from the first time that they were informed about the incurable nature of their disease through to postsurgery palliative treatment.SettingsPatients with colorectal cancer receiving palliative chemotherapy.Research designWe used a qual…

Research designAdultMalemedicine.medical_specialtyPalliative careColorectal cancer1720vulnerabilitycompassionDiseasepalliative care informationInterviews as Topic03 medical and health sciences0302 clinical medicineLife ExpectancyDrug TherapymedicineHumans030212 general & internal medicine1506Disease prognosisQualitative ResearchAgedPhysician-Patient Relationsbusiness.industryNorwayCommunicationResearchPalliative CareGeneral MedicineMiddle Agedlife-worldmedicine.diseasePrognosisPeer reviewVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762Family medicineLife expectancyFemalebusinessColorectal Neoplasms030217 neurology & neurosurgeryQualitative researchBMJ open
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Prevalence and Prognostic Impact of Diabetes in Takotsubo Syndrome: Insights From the International, Multicenter GEIST Registry

2017

OBJECTIVE In view of low prevalence rates, diabetes is discussed as a protective factor for the occurrence of Takotsubo syndrome (TTS). Furthermore, it was associated with improved outcome in a small single-center analysis. Therefore, this study assessed the prevalence and prognostic relevance of concomitant diabetes in TTS. RESEARCH DESIGN AND METHODS A total of 826 patients with TTS were enrolled in an international, multicenter, registry-based study (eight centers in Italy and Germany). All-cause mortality was compared between patients with diabetes and patients without diabetes, and the independent predictive value of diabetes was evaluated in multivariate regression analysis. RESULTS …

Research designMalemedicine.medical_specialtyDiabetic CardiomyopathiesEndocrinology Diabetes and MetabolismMEDLINEPrevalenceProtective factorDiabetes Takotsubo030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineRisk FactorsTakotsubo CardiomyopathyDiabetes mellitusInternal medicineGermanyInternal MedicineDiabetes MellitusPrevalenceMedicineHumans030212 general & internal medicineRegistriesAgedAdvanced and Specialized NursingTakotsubo syndromebusiness.industryMortality rateMiddle Agedmedicine.diseasePrognosisItalyConcomitantFemalebusiness
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Low intensity vs. self-guided Internet-delivered psychotherapy for major depression: A multicenter, controlled, randomized study

2013

Abstract Background Major depression will become the second most important cause of disability in 2020. Computerized cognitive-behaviour therapy could be an efficacious and cost-effective option for its treatment. No studies on cost-effectiveness of low intensity vs self-guided psychotherapy has been carried out. The aim of this study is to assess the efficacy of low intensity vs self-guided psychotherapy for major depression in the Spanish health system. Methods The study is made up of 3 phases: 1.- Development of a computerized cognitive-behaviour therapy for depression tailored to Spanish health system. 2.- Multicenter controlled, randomized study: A sample (N=450 patients) with mild/mod…

Research designMalemedicine.medical_treatmentCost-Benefit Analysis:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]law.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Study ProtocolRandomized controlled trialQuality of lifeClinical Protocols:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder Major [Medical Subject Headings]law:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols [Medical Subject Headings]Tratamiento asistido por ordenadorDepression (differential diagnoses)DepressionMiddle Aged:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychotherapy::Behavior Therapy::Cognitive Therapy [Medical Subject Headings]Psychiatry and Mental healthTreatment OutcomeResearch DesignRandomized controlled trial:Information Science::Information Science::Computing Methodologies::Computer Systems::Computer Communication Networks::Internet [Medical Subject Headings]FemaleAnálisis Costo-BeneficioPsychologyAdultmedicine.medical_specialtyPsychotherapist:Check Tags::Male [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Therapy Computer-Assisted [Medical Subject Headings]:Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis::Cost-Benefit Analysis [Medical Subject Headings]Trastorno depresivo mayor:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineHumansPsychiatryComputer-delivered psychotherapy:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]Depressive Disorder MajorInternetIntention-to-treat analysisCognitive Behavioral TherapyBeck Depression InventoryClinical trial:Check Tags::Female [Medical Subject Headings]Diseño de la investigaciónTherapy Computer-AssistedProtocolos clínicosCognitive therapyResultado del tratamientoTerapia cognitiva
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Building a continuous multicenter infection surveillance system in the intensive care unit: findings from the initial data set of 9,493 patients from…

2008

OBJECTIVE: To describe the epidemiology of infections in intensive care units (ICUs), whether present at admission or acquired during the stay. METHODS: Prospective data collection lasting 6 months in 71 Italian adult ICUs. Patients were screened for infections and risk factors at ICU admission and daily during their stay. MAIN RESULTS: Out of 9,493 consecutive patients admitted to the 71 ICUs, 11.6% had a community-acquired infection, 7.4% a hospital-acquired infection, and 11.4% an ICU-acquired infection. The risk curve of acquiring infection in the ICU was higher in patients who entered without infection than in those already infected (log-rank test, p < .0001; at 15 days, 44.0% vs. 34.6…

Resuscitationmedicine.medical_specialtyMedical Records Systems ComputerizedQuality Assurance Health Carehealth care facilities manpower and servicescritically illCritical Care and Intensive Care MedicineInfectionslaw.inventioncritical care medicine sepsis infectious diseaselawRisk FactorsIntensive careEpidemiologymedicineInfection controlHumansHospital MortalityProspective StudiesIntensive care medicineInfection surveillancebusiness.industrySeptic shockIncidenceLength of StayMiddle Agedmedicine.diseasePrognosisIntensive care unitinfection controlinfectionIcu admissionsevere sepsisSurvival RateIntensive Care Unitsinfection control controlLogistic ModelsItalyPopulation Surveillanceseptic shockbusinessintensive care units critically ill infection infection control severe sepsis septic shockCritical care medicine
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Mutation Analysis Identifies GUCY2D as the Major Gene Responsible for Autosomal Dominant Progressive Cone Degeneration

2008

PURPOSE. Heterozygous mutations in the GUCY2D gene, which encodes the membrane-bound retinal guanylyl cyclase-1 protein (RetGC-1), have been shown to cause autosomal dominant inherited cone degeneration and cone–rod degeneration (adCD, adCRD). The present study was a comprehensive screening of the GUCY2D gene in 27 adCD and adCRD unrelated families of these rare disorders. METHODS. Mutation analysis was performed by direct sequencing as well as PCR and subsequent restriction length polymorphism analysis (PCR/RFLP). Haplotype analysis was performed in selected patients by using microsatellite markers. RESULTS. GUCY2D gene mutations were identified in 11 (40%) of 27 patients, and all mutation…

Retinal degenerationMaleDNA Mutational AnalysisReceptors Cell SurfaceBiologyPolymerase Chain ReactionArticlemedicineElectroretinographyMissense mutationHumansGenetic Predisposition to DiseaseCodonGeneGeneticsHaplotypeRetinal DegenerationDNAmedicine.diseasePrognosisRod Cell Outer SegmentMajor geneMolecular biologyPedigreeHaplotypesGuanylate CyclaseMutationMutation testingDisease ProgressionGUCY2DFemaleRestriction fragment length polymorphism
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An integrated framework for risk profiling of breast cancer patients following surgery.

2006

Objective: An integrated decision support framework is proposed for clinical oncologists making prognostic assessments of patients with operable breast cancer. The framework may be delivered over a web interface. It comprises a triangulation of prognostic modelling, visualisation of historical patient data and an explanatory facility to interpret risk group assignments using empirically derived Boolean rules expressed directly in clinical terms. Methods and materials: The prognostic inferences in the interface are validated in a multicentre longitudinal cohort study by modelling retrospective data from 917 patients recruited at Christie Hospital, Wilmslow between 1983 and 1989 and predictin…

Risk profilingAdultmedicine.medical_specialtyDecision support systemMedicine (miscellaneous)Breast NeoplasmsMachine learningcomputer.software_genreModels BiologicalRisk AssessmentDecision Support TechniquesUser-Computer InterfaceBreast cancerRisk groupsArtificial IntelligencemedicineConfidence IntervalsHealth Status IndicatorsHumansMedical physicsSurvival analysisMastectomyRetrospective StudiesInternetbusiness.industryPatient SelectionReproducibility of ResultsPatient dataMiddle Agedmedicine.diseaseDecision Support Systems ClinicalPrognosisConfidence intervalTreatment OutcomeNottingham Prognostic IndexFemaleArtificial intelligenceNeural Networks ComputerbusinesscomputerMonte Carlo MethodAlgorithmsArtificial intelligence in medicine
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