Search results for "PROGRESS"

Ayn Rand's fiction and the shaping of modern american individualism

2018

A lo largo de la historia, han surgido varios movimientos políticos y filosóficos, pero la gran mayoría no han perdurado. Sin embargo, algunos, como la democracia o el comunismo se popularizan y afectan al mundo entero. Aquí en los Estados Unidos, la nueva filosofía quizás más desafiante e inusual ha sido formada por la novelista, Ayn Rand. El punto de vista de Rand sigue siendo relativamente desconocido en América, pero si se arraigase, revolucionaría nuestras vidas. Esta cita fue la introducción para la entrevista hecha a Ayn Rand en 1959 por el reportero legendario, Mike Wallace. En ese momento, la audiencia no podía comprender completamente la presciencia de Wallace, y hoy en día no se …

Effects of Pleurotus eryngii var. eryngii in "in vitro" and "in vivo" cancerogenetic models

2018

Heat shock proteins (Hsps) are highly expressed in a variety of cancer types contributing to tumor cell propagation and protection against apoptosis [1]. The current anti-cancer therapy is not always target specific and often is associated with complications for patients, Therefore new effective, specific and less toxic therapeutic approaches are needed. Medicinal mushrooms have emerged as wonderful source of nutraceuticals, anti-oxidants, anticancer, prebiotic, anti-inflammatory, cardiovascular, anti-microbial, and anti-diabetic. The ongoing research projects are aimed to promote mushrooms as new generation ‘‘biotherapeutics’’[2]. The aim of this study was to evaluate whether the cold-wate…

Melnkalnes un Serbijas ceļš uz ES no 2006. līdz 2015. gadam

2016

Maģistra darbā “Melnkalnes un Serbijas ceļš uz ES no 2006. līdz 2015. gadam” galvenais mērķis bija izanalizēt ES paplašināšanas konceptu, darbības struktūru, no kādas teorētiskas perspektīvas to var petīt, un kuru no divām kandidātvalstīm var uzskatīt par potenciālo dalībvalsti no ES pozīcijas. Teorētiskajā daļā uzmanība galvenokārt tika pievērstā idejai par ES paplašināšanās pastāvošām dimensijām, kas sniedz vairākas pieejas no kurām var aplūkot pašu paplašināšanas procesu. Šīs dimensijas tika aplūkotas caur divu teorētisko skolu prizmām: racionālisms un konstruktīvisms. Empīriskajā daļā pētījuma rezultāti atspoguļo Melnkalnes un Serbijas liberālo normu attīstību ceļā uz ES. Secinājumos ir…

Spanish Menopause Society position statement: Use of denosumab in postmenopausal women

2014

Denosumab is a new drug developed for the treatment of osteoporosis. Moreover, increasing evidences link denosumab with benefits in cancer, an area of interest for those in charge of the postmenopausal health. Denosumab has shown efficacy in the control of bone loss associated with hypogonadic states created by chemotherapy in breast and other cancers. Moreover, some studies reveal efficacy in reducing the progression of metastases. A panel of experts from the Spanish Menopause Society has met to develop usage recommendations based on the best available evidence.

Summary and recommendations of the OARSI FDA osteoarthritis Assessment of Structural Change Working Group

2011

Import JabRef | WosArea Orthopedics; Rheumatology; International audience; Objective: The Osteoarthritis Research Society International initiated a number of working groups to address a call from the US Food and Drug Administration (FDA) on updating draft guidance on conduct of osteoarthritis (OA) clinical trials. The development of disease-modifying osteoarthritis drugs (DMOADs) remains challenging. The Assessment of Structural Change (ASC) Working Group aimed to provide a state-of-the-art critical update on imaging tools for OA clinical trials. Methods: The Group focussed on the performance metrics of conventional radiographs (CR) and magnetic resonance imaging (MRI), performing systemati…

Comparative evaluation of three semi-quantitative radiographic grading techniques for knee osteoarthritis in terms of validity and reproducibility in…

2008

OBJECTIVE: The objective of this work was to compare the measurement properties of three categorical X-ray scoring methods of knee osteoarthritis (OA), both on semiflexed and extended views. METHODS: In data obtained from trials and cohorts, X-rays were graded using Kellgren and Lawrence (KL), the OA Research Society International (OARSI) joint space narrowing score, and measurement of joint space width (JSW). JSW was analyzed as a categorical variable. Construct validity was assessed through logistic regression between X-ray stages and Western Ontario and McMaster Universities OA Index. Inter-observer reliability was assessed in 50 subjects for extended views by weighted kappa. Intra-obser…

Clinical and Instrumental Findings and Disability Progression in Primary Progressive and Progressive Relapsing Multiple Sclerosis: A Comparison Study…

2013

Primary progressive crossed aphasia in dextrals: report of three cases

2013

Conditions et enjeux pédagogiques de la constitution de classes à cours multiples dans les écoles primaires

2006

06022; La problématique de cette recherche s'inscrit dans le schéma global suivant, qui se donne pour objectif d'analyser successivement les pratiques de constitution des classes (nombre et nature des classes au sein des écoles), les modalités d'affectation des élèves et des enseignants dans ces classes et enfin l'efficacité pédagogique des différents types de groupement réalisés.

Therapeutic targeting of apoptotic pathways in cancer.

2006

Programmed cell death (apoptosis) is a key tumor suppressor mechanism. Consequently, most if not all cancers develop mechanisms to abolish or circumvent this genetic program. Besides enabling malignant transformation and tumor progression, defects in apoptosis can result in resistance to cytotoxic cancer therapies. Much progress has been made in the delineation of the molecular pathways leading to apoptosis. This allows the identification of target molecules and lead compounds to develop novel therapies, which make use of this intrinsic death program for the treatment of cancer. Here, we review the current understanding of apoptotic signal transduction pathways, and strategies of their ther…