Search results for "PROGRESS"

Comparison of global visual field indices (MD,VFI), GPA II change and cluster analysis of visual field progression in glaucoma

2014

Concorsi pubblici e progressioni di carriera nella stagione del "grande reclutamento"

2022

il saggio affronta i principali problemi del sistema dei concorsi pubblici e della disciplina delle progressioni di carriera nel pubblico impiego privatizzato, alla luce delle innovazioni contenute nel d.l. 80/2021 e nella della sottoscrizione del nuovo CCNL per il comparto Funzioni Centrali.

Follow-up in transthyretin familial amyloid polyneuropathy: Useful investigations

2020

Patients with transthyretin amyloid polyneuropathy (TTR-FAP) and asymptomatic mutation-carriers have to be regularly followed-up in order to identify disease progression and the time point for starting or modifying therapy. In this case series we describe the potential suitability of different variables as progression markers. We retrospectively analyzed the follow-up charts of 10 TTR-FAP patients. Clinical examination included the Neuropathy Impairment Score of Lower Limb (NIS-LL), temperature perception thresholds, nerve conduction and autonomic function tests. The NIS-LL had the greatest value for a sensitive and correct follow-up for all TTR-FAP stages. All other examinations provided u…

Czy Peirce był konserwatystą?

2015

The main aim of this paper is to consider from different points of view the thesis of a conservative character of Peirce’s thought. The paper consists of two parts. In the first part, arguments for Peirce’s conservatism are presented. They are of two kinds: inner ones (Peirce’s own declarations) and outer ones (a comparison of Peirce’s view o the views of two other classical pragmatists: James and Dewey). The second part of the paper is devoted to counterarguments – the main one is the fact that Peirce is an author of the conception of an unlimited community of inquirers. This conception was an inspiration to the vision of the world and social activities which were perceived as unambiguousl…

Enhanced Lipid Peroxidation and Platelet Activation in the Early Phase of Type 1 Diabetes Mellitus

2003

Background— To investigate early events possibly related to the development of diabetic angiopathy, we examined whether 8-iso-prostaglandin F 2α (8-iso-PGF 2α ) formation, a marker of in vivo oxidant stress, is altered in different stages of type 1 diabetes (T1DM) and whether it correlates with the rate of thromboxane (TX) A 2 biosynthesis, a marker of in vivo platelet activation. We also investigated the relationship between inflammatory markers and F 2 -isoprostane formation in this setting. Methods and Results— A cross-sectional study was performed in 23 insulin-treated patients aged <18 years with new-onset T1DM (≤6 weeks, group A), matched for age and gender with 23 patients with s…

Didactologies/didactique des langues-cultures et didactique de la musique du français: réflexion (s) en 2016

2016

Revenant aux sources de définitions de la Didactologie/didactique des languescultures élaborées par Robert Galisson dans les années 1985-1986 en particulier, on constate que le paysage didactique actuel est fortement marqué par la prépondérance du recours à divers modes d’application relativement contrôlables, alors que l’on aurait pu croire que cette tendance était de nos jours révolue. Cette démarche permet également de remarquer l’aide apportée par Robert Galisson pour la démonstration de la légitimité de la Didactique de la musique du français (1996) à une époque où le Cadre européen commun de référence pour les langues n’était pas encore paru ni appliqué. Ces rétrospections sont l’occa…

Predictors for Therapy Response to Intrathecal Corticosteroid Therapy in Multiple Sclerosis

2019

\(\bf Objective:\) The autoimmune disease Multiple Sclerosis (MS) represents a heterogeneous disease pattern with an individual course that may lead to permanent disability. In addition to immuno-modulating therapies patients benefit from symptomatic approaches like intrathecal corticosteroid therapy (ICT), which is frequently applied in a growing number of centers in Germany. ICT reduces spasticity, which elongates patient's walking distance and speed, thus improves quality of life. \(\bf Methods:\) In our study we set out to investigate cerebrospinal fluid (CSF) parameters and clinical predictors for response to ICT. Therefore, we analyzed 811 CSF samples collected from 354 patients over …

90Yttrium-Ibritumomab Tiuxetan as First Line Treatment for Follicular Non-Hodgkin Lymphoma. 5 Year Results from an International Multicenter Phase II…

2016

Abstract Purpose Updated 5 year results are presented from the multicenter phase II trial of 90Yttrium-Ibritumomab-Tiuxetan (90YIT) as first line stand-alone therapy for patients with follicular lymphoma (FL). Patients and Methods 59 patients with CD20-positive FL grade 1 to 3a in stages II with bulky disease (n=12), III (n= 26), or IV (n=21), and in need for therapy, were enrolled between 05/2007 and 06/2010. They received 90YIT according to standard procedure (rituximab 250 mg/m2 days -7 and 0, then 90YIT 15 MBq/kg (0.4mCi/kg) day 0; patients with platelet counts below 150.000/ul but above 100.000/ul received only 11 MBq/kg). Primary end point was the clinical and molecular remission rate…

Expression of tenascin in human cervical cancer--association of tenascin expression with clinicopathological parameters.

1999

Tenascin is an extracellular matrix glycoprotein, relevant for embryonal and fetal development, which is reexpressed in the stroma of benign and malignant tumors. Little is known about the molecular interaction of tenascin during neoplastic transformation and tumor progression in cervical cancer.We studied the expression of tenascin in normal tissue of the cervix uteri, cervical carcinoma in situ, and invasive cervical carcinoma in paraffin sections by immunohistochemistry using a monoclonal antibody. Tenascin immunoreactivity was compared with various prognostic parameters.In normal cervical tissue (n = 5) and in cervical carcinoma in situ (n = 10) only vessel walls showed a weak tenascin …

EZH2 mutations are frequent and represent an early event in follicular lymphoma

2013

Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with follicular lymphoma (FL) (n = 366) and performed a longitudinal analysis of mutation during the disease progression from FL to transformed FL (tFL) (n = 33). Mutations were detected at 3 recurrent mutation hot spots (Y646, A682, and A692) in 27% of FL cases with variant allele frequencies (VAF) ranging from 2% to 61%. By comparing VAF of EZH2 with other mutation targets (CREBBP, MLL2, TNFRSF14, and MEF2B), we were able to distinguish patients harbori…