Search results for "PROGRESS"
showing 10 items of 1620 documents
Adaptive meshes in computer graphics and model-based simulation
2006
Monet luonnonlait voidaan ilmaista matemaattisesti joko yhtenä yhtälönä tai yhtälöjärjestelmänä. Erityisesti differentiaaliyhtälöiden ratkaisu on tärkeä esimerkiksi mekaniikassa, biologiassa tai kemiassa esiin tuleva ongelma. Useimmissa tapauksissa ratkaisu tällaisiin yhtälöihin on tuntematon, joten se täytyy löytää käyttäen tietokonekoodia. Koska tietokoneet toimivat rajoitetulla tarkkuudella ja tietomäärällä, tietokoneella saatu ratkaisu on vain approksimaatio yhtälön ratkaisulle. Tämän epätarkan tiedon käyttö tietokoneavusteisessa tekniikassa voi johtaa laitteen toimintahäiriöihin. Onkin tärkeää saada kuva, kuinka hyvin tietokoneella saatu tulos edustaa tarkkaa ratkaisua. Turchyn kehitti…
Mathematical modeling and competencies for biology students
2017
International audience; The research aims at introducing modeling tasks with an ultimate goal to engage students more actively into learning mathematics through tasks that are biologically 'colored'. My focus is on the individual progression (if any) of students' mathematical competencies during a sequence of modeling sessions as part of their first year mathematics. My goal is to explore the nature of progression within the competency profile of participating student, the relation between modeling processes and this progression and what transformations are applied in these sets of competencies.
La Unión Liberal en el sistema político isabelino. Concepciones, alcances y limitaciones (1858-1863) The Liberal Union in the political Elizabethan s…
2017
Este artículo pretende revisar el estado actual de conocimientos sobre una formación política, la Unión Liberal, que presidió el Gobierno más largo y estable de la era isabelina. El unionismo es un proyecto político que tradicionalmente ha sufrido la desatención de la historiografía por ser considerado continuación o solución estratégica para que el moderantismo clásico se perpetuase en el poder. Mi investigación trata de cuestionar esta línea interpretativa y enfatizar que el unionismo puede agrietar más si cabe la tesis de la debilidad del liberalismo español.La Unión Liberal fue un experimento político, original e innovador, que bajo premisas ya contempladas en la cultura liberal, reinte…
Cardiorenal syndrome type 4: From chronic kidney disease to cardiovascular impairment
2016
Cardiorenal syndrome type 4 (CRS type 4), or chronic renocardiac syndrome, has been defined as "chronic abnormalities in renal function leading to cardiac disease" and recognizes the extreme burden of cardiovascular disease (CVD) risk in patients with chronic kidney disease (CKD). CKD is common and increasingly recognized as a risk factor for CVD. Even though the treatment for CVD has dramatically improved over the past decades, it still takes responsibility for up to 50% of deaths in CKD patients. For this reason, patients with CKD should be thoroughly evaluated for cardiovascular risk factors that require careful management, given the significant burden of CRS type 4 on the healthcare sys…
Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease.
2019
Background & Aim There is an unmet need for non-invasive biomarkers in non-alcoholic fatty liver disease (NAFLD) that can diagnose advanced disease and identify patients suitable for clinical trials. The PRO-C3 collagen neo-epitope is a putative direct marker of fibrogenesis. We assessed the performance of PRO-C3 in a large, well-characterised international NAFLD cohort and report the development and validation of 2 novel panels for the diagnosis of advanced fibrosis (F≥3) in NAFLD, including a simplified clinical score which eliminates the need for online calculators. Methods Plasma PRO-C3 levels were determined in a prospectively recruited international cohort of 449 patients with biopsy …
Burden of illness of progressive familial intrahepatic cholestasis in the US, UK, France, and Germany: study rationale and protocol of the PICTURE st…
2021
Background: Progressive familial intrahepatic cholestasis (PFIC) is an ultra-rare disease with a considerable burden on pediatric patients and their caregivers, impacting quality of life (QoL). The mortality rates highlight a significant need for efficacious treatments. Real-world data on associated costs and QoL are needed to gauge the potential impact of new pharmacological treatments. Methods: Clinical and socio-economic burden of PFIC on patients/caregivers, health systems, and society will be assessed. Patient/caregiver- and physician-level retrospective cross-sectional data will be collected from the US, UK, France, and Germany, for PFIC types 1, 2, 3. A representative sample of physi…
Current management of atopic dermatitis and interruption of the atopic march.
2003
Treatment of atopic dermatitis requires a comprehensive approach that includes evaluation of potential triggers and education of the patient and family regarding proper avoidance measures. Hydration of the skin and maintenance of an intact skin barrier remain integral to proper management. Although topical corticosteroids have been a mainstay of anti-inflammatory therapy, the newer topical calcineurin inhibitors offer advantages for treatment of this chronic, relapsing disease. Studies aimed at defining optimal combination therapy and early intervention might change the treatment paradigm for atopic dermatitis.
Epidemiology and pathophysiology of left ventricular abnormalities in chronic kidney disease: a review.
2010
Introduction Cardiovascular diseases are highly prevalent in patients with chronic kidney disease (CKD), and represent the major hazard for mortality in this population. Anomalies of left ventricular (LV) structure and function are very frequent too among CKD patients, and show a negative impact on cardiovascular prognosis. Methods We searched PubMed for manuscripts regarding left ventricular hypertrophy (LVH) in CKD. Definition of LVH was different according to different studies. Results In patients with end-stage renal disease, the prevalence of LVH is higher than 70%. Studies in patients with less advanced CKD have reported increasing prevalence of LVH along with declining renal function…
Ocular motor biomarkers in Niemann-Pick disease type C: A prospective cross-sectional multicontinental study in 72 patients
2020
AbstractNiemann-Pick type C (NPC) is a rare lysosomal storage disorder with ocular motor involvement. In a multicontinental, cross-sectional study we characterized ocular motor function in 72 genetically proven patients from twelve countries by means of video-oculography. Interlinking with disease severity, we also searched for ocular motor biomarkers. Our study protocol comprised reflexive and self-paced saccades, smooth pursuit, and gaze-holding in horizontal and vertical planes. Data were compared with those of 158 healthy controls. The Modified Disability Rating Scale, Scale for Assessment and Rating of Ataxia, Spinocerebellar Ataxia Functional Index for neurological status, and Montrea…
A retrospective analysis of pegylated liposomal doxorubicin in ovarian cancer: do we still need it?
2012
Abstract Background Ovarian cancer (OC) is the sixth most common cancer in women. Currently, carboplatin/paclitaxel ± bevacizumab is the cornerstone of front-line treatment. Conversely, the therapeutic options for recurrent or progressive disease are not well defined. For platinum-sensitive patients the best therapeutic approach is still a re-challenge with a platinum-based regimen. Pegylated liposomal doxorubicin (PLD), is considered one of the most active therapeutic options for recurrent or progressive OC. In this retrospective mono-institutional analysis, we evaluated the impact of PLD on the outcome of OC patients. Patients and methods We performed the retrospective study on a cohort o…