Search results for "PROTECTION"
showing 10 items of 1623 documents
Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo
2019
Dysfunction of autophagy and disturbed protein homeostasis are linked to the pathogenesis of human neurodegenerative diseases and the modulation of autophagy as the protein clearance process has become one key pharmacological target. Due to the role of sigma-1 receptors (Sig-1R) in learning and memory, and the described pleiotropic neuroprotective effects in various experimental paradigms, Sig-1R activation is recognized as one potential approach for prevention and therapy of neurodegeneration and, interestingly, in amyotrophic lateral sclerosis associated with mutated Sig-1R, autophagy is disturbed. Here we analyzed the effects of tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine hyd…
L'inclusione finanziaria come strumento di cittadinanza degli immigrati
2021
La actual crisis económica, producto de la propagación del COVID-19, que provocó el bloqueo de cadenas productivas enteras, replantea dramáticamente el tema de la inclusión financiera de personas en condiciones de vulnerabilidad económica y social, como los inmigrantes. El fenómeno de la inclusión financiera de los inmigrantes, en general, tiene un carácter multidimensional, estando vinculado a factores sociales, culturales, lingüísticos y religiosos. La definición de inclusión financiera postula una definición previa de la otra cara de la moneda, que es la exclusión financiera, que tiene una estrecha relación con la exclusión social, siendo una la causa de la otra, en una especie de círcul…
The Use of Bark in Biomonitoring Heavy Metal Pollution of Forest Areas on the Example of Selected Areas in Poland
2020
Abstract In the year 2016, passive biomonitoring studies were conducted in the forest areas of southern and north-eastern Poland: the Karkonosze Mountains (Kark), the Beskidy Mountains (Beskid), Borecka Forest (P. Bor), Knyszynska Forest (P. Kny), and Białowieza Forest (P. Bia). This study used bark from the tree, Betula pendula Roth. Samples were collected in spring (Sp), summer (Su), and autumn (Au). Concentrations of Mn, Fe, Ni, Cu, Zn, Cd, and Pb were determined for the samples using the atomic absorption spectrometry method with flame excitation (F-AAS). Based on the obtained results, the studied areas were ranked according to level of heavy-metal deposition: forests of southern Poland…
Protection intellectuelle de la base de données «Microsol database ©»
2011
Ce document n'est pas un brevet. Certificat délivré par l' Agence pour la Protection des Programmes. Support CD-ROM. N°adhérent: 87.75.4 Logibox conservé par l'adhérent: 67757. Protection intellectuelle de la plateforme GenoSol qui permettra d’avoir un référentiel de la biodiversité microbienne des sols
THE BIO-PROTECTIVE ROLE OF A BIOLOGICAL ENCRUSTATION
2014
Benthic organisms can form a persistent biological layer that mediates processes of rock deterioration and limits the degradation of the underlying surface. In this study we investigated the bioprotective potential of barnacle encrustations against salt weathering processes, and discuss their possible role in enhancing the durability of coastal engineering structures
La protection agroécologique appliquée
2020
National audience; Le sol est un milieu complexe. Son étude et l’acquisition de références solides sur ses interactions avec les cultures s’inscrit dans la durée. En pratique, il est d’ores et déjà possible d’appliquer certains principes agroécologiques à la protection contre les bioagresseurs pendant la phase d’implantation, en les adaptant à chaque situation et aux objectifs visés.
Radon levels in the Valencian community (Spain). I. Results in the province of Valencia (1990–1991)
1995
Abstract Two-day radon screening measurements with charcoal canisters were made in buildings in the province of Valencia throughout the years 1990 and 1991. An average indoor concentration of 34 Bq m −3 was found, and 9% of all measurements exceeded the recommended EPA limit of 148 Bq m −3 .
Grp78 overexpression triggers pink1-ip3 r-mediated neuroprotective mitophagy
2021
An experimental model of spinal root avulsion (RA) is useful to study causal molecular programs that drive retrograde neurodegeneration after neuron-target disconnection. This neurode-generative process shares common characteristics with neuronal disease-related processes such as the presence of endoplasmic reticulum (ER) stress and autophagy flux blockage. We previously found that the overexpression of GRP78 promoted motoneuronal neuroprotection after RA. After that, we aimed to unravel the underlying mechanism by carrying out a comparative unbiased proteomic analysis and pharmacological and genetic interventions. Unexpectedly, mitochondrial factors turned out to be most altered when GRP78…
Mildronate as a Regulator of Protein Expression in a Rat Model of Parkinson’s Disease
2011
Background. Mildronate (3-[2,2,2-trimethylhydrazinium] propionate dihydrate) traditionally is a well-known cardioprotective drug. However, our recent studies convincingly demonstrated its neuroprotective properties. The aim of the present study was to evaluate the influence of mildronate on the expression of proteins that are involved in the differentiation and survival of the nigrostriatal dopaminergic neurons in the rat model of Parkinson’s disease (PD). The following biomarkers were used: heat shock protein 70 (Hsp70, a molecular chaperone), glial cell line-derived nerve growth factor (GDNF, a growth factor promoting neuronal differentiation, regeneration, and survival), and neural cell …
Neurotrophic effects of central nicotinic receptor activation
2000
A growing number of data have shown that compounds interacting with neuronal nicotinic acetylcholine receptors (nAChRs) have, both in vivo and in vitro, the potential to be neuroprotective and that treatment with nAChR agonists elicit long-lasting improvement of cognitive performance in a variety of behavioural tests in rats, monkeys and humans. Epidemiological and clinical studies suggested also a potential neuroprotective/trophic role of (-)-nicotine in neurodegenerative disease, such as Alzheimer's disease and Parkinson's disease. This neuroprotective/trophic role of nAChR activation has been mainly mediated by alpha7 and alpha4beta2 nAChR subtypes, as evidenced using selective nAChR ant…